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Committee for the Protection of Human Subjects
Phone: (603) 646-6482
Fax: (603) 646-9141
Interdepartmental Mail:
HB 6254
Committee for the Protection of Human Subjects
63 South Main Street, Room 302
Hanover, NH 03755

Upcoming Events

December 11
3 PM - 4 PM
IRB Education Session
DHMC, Borwell 758W

December 12
11 AM - 1 PM
Office Hours
GSMD Registrar's Suite, DHMC

The Committee for the Protection of Human Subjects

The Committee for the Protection of Human Subjects (CPHS) is the Institutional Review Board (IRB) at Dartmouth College- a federally mandated committee with the charge of overseeing institutional research projects involving human participants. The CPHS serves as the IRB for Dartmouth College and Dartmouth-Hitchcock Medical Center.

The mission of the CPHS is to protect the rights and welfare of research participants.

The CPHS relies on the ethical principles identified in the Belmont Report in its review of research projects. These principles are respect for persons, beneficience and its corollary non-maleficence, and justice.

The CPHS also adheres to applicable federal regulations for human subject protection. These regulations include 45 C.F.R. 46 and, when applicable, 38 C.F.R. 16, and 21 C.F.R. Parts 50 and 56. The CPHS recognizes and applies when appropriate the guidance of the International Committee on Harmonization (ICH), and Good Clinical Practices (GCP) as acknowledged by the Food and Drug Administration.

All submissions to CPHS must be completed via RAPPORT.  RAPPORT is a web-based integrated research administration system that will manage submissions and correspondence with CPHS.  Access RAPPORT at the link below.  


Request to Rely on the Dartmouth CPHS as the IRB of Record for a multi-site study.

To be proactive and most efficient – Send each external site the three documents listed below and proceed as follows:

1. Request to Rely on the Dartmouth CPHS Form
It is important to indicate the research being conducted at each site (e.g. data analysis only, full protocol). The Request to Rely Form is to be completed with each site and their local IRB if needed.

2. Dartmouth IRB Reliance Agreement. This is the signature page for the Site Authorized Individual, local site PI and Dartmouth.
To be proactive and most efficient the Site Authorized Individual and local site PI can sign off prior to submission to CPHS.

3. Responsibilities and Communications Plan. The Plan outlines responsibilities of the CPHS and of the external Site. Please be sure this Plan is attached with the Dartmouth IRB Reliance Agreement and Request to Rely Form.

After completion upload the 3 documents with the local consent form (if applicable) to CPHS Rapport with the initial study submission or via a modification request.

The CPHS will review the Request to Rely Form and counter sign the Dartmouth IRB Reliance Agreement. The CPHS will upload the final IRB Reliance Agreement into Rapport. The completed IRB Reliance Agreement can then be sent to the local site by the research team.

Important notes:
a. If the external site is part of the SMART IRB consortium, the SMART IRB process and reliance form may be followed. The SMART IRB Acknowledgement Form is signed /clicked. This process may (or may not) also include use of the SMART IRB portal.

b. If the external site submits their own IRB Reliance Agreement. Dartmouth will consider utilizing it with a completed 'Request to Rely on Dartmouth CPHS Form" and 'Dartmouth: Responsibility and Communication Plan' attached and referred to in the Reliance Agreement with signature.

c. There may be a fee involved to request the use of the CPHS as the IRB of Record. Please contact the CPHS Office for current pricing.

Upcoming Events and Announcements

Registration information for IRB Education Sessions is located on our Education page.


1) Human subjects protection (HSP) training requires a three (3) year refresher course available on CITI.

2)  Update on NIH Single IRB of Record (sIRB)

3)  Are YOU on the CPHS - ANNOUNCEMENTS Listserv? If not, please email our office and let us know you would like to get important announcements! Contact us here

4)  RAPPORT is a web-based integrated research administration system that manages submissions and correspondence with CPHS. RAPPORT must be used for all submissions, including initial applications, renewals, revisions, SAEs, protocol deviations, etc.

Last Updated: 9/26/18