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Assistant Professor
Ph.D., Harvard University, Cambridge, Mass. 1998
Office: (603) 646-0610, Moore 259
Lab: (603) 646-0047, Moore B28
Jerald.D.Kralik@Dartmouth.edu
Interests
My laboratory focuses on decision making and executive function. We
study how coherent decisions result from the interplay of many underlying brain
systems, each with a different evolutionary history, and each vying to control
our behavior. For example, how do higher-order brain areas, such as
prefrontal cortex, inhibit lower-order structures when we have the urge to make
impulsive decisions? Our laboratory approaches such questions with
neurophysiological, behavioral and computational modeling methods, with the
goal of understanding fundamental principles of brain function and developing
biomedical treatments for dysfunctional decision-making in disorders ranging
from substance abuse to attention deficit/hyperactivity disorder.
Selected publications
Chudasama, Y., Kralik, J. D., and Murray, E. A. (2007). Rhesus
monkeys with orbital prefrontal cortex lesions can learn to inhibit prepotent
responses in the reversed-reward contingency task. Cerebral
Cortex, 17: 1154-1159.
Kralik, J. D. (2005). Inhibitory control and response selection in
problem solving: How cotton-top tamarins (Saguinus oedipus)
overcome a bias for selecting the larger quantity of food. Journal of
Comparative Psychology, 119: 78-89.
Murray, E. A., Kralik, J. D., and Wise, S. P. (2005). Learning to
inhibit prepotent responses: Successful performance by rhesus macaques on the
reversed-contingency task. Animal Behaviour, 69:
991-998.
Santucci, D. M., Kralik, J. D., Lebedev, M. A., and Nicolelis, M. A. L.
(2005). Frontal and parietal cortical ensembles predict single-trial
muscle activity during reaching movements. European Journal of
Neuroscience, 22: 1529-1540. (Cover article)
Lebedev, M. A., Messinger, A., Kralik, J. D., and Wise, S. P. (2004).
Representation of attended versus remembered locations in prefrontal
cortex. Public Library of Science (PLoS) Biology, 2:
1919-1935.
Nicolelis, M. A. L., Dimitrov, D., Carmena, J., Crist, R., Lehew, G.,
Kralik, J. D., and Wise, S. P. (2003). Chronic, multi-site,
multi-electrode recordings in macaque monkeys. Proceedings of the
National Academy of SciencesUSA, 100: 11041-11046.
Kralik, J. D., Hauser, M. D., and Zimlicki, R. (2002). The
relationship between problem solving and inhibitory control: Cotton-top
tamarin (Saguinus oedipus) performance on a reversed contingency
task. Journal of Comparative Psychology, 116: 39-50.
Kralik, J. D., Dimitrov, D. F., Krupa, D. J., Katz, D. B., Cohen, D., and
Nicolelis, M. A. L. (2001). Techniques for chronic, multisite neuronal
ensemble recordings in behaving animals. Methods, 25:
121-150.
Wessberg, J., Stambaugh, C. R., Kralik, J. D., Beck, P. D., Laubach, M.,
Chapin, J. K., Kim, J., Biggs, S. J., Srinivasan, M. A., and Nicolelis, M. A.
L. (2000). Real-time prediction of hand trajectory by ensembles of
cortical neurons in primates. Nature, 408: 361-365.
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