(Curriculum Vitae) Professor Wu received his A.B. degree in Chemistry from Princeton University in 1998. He then spent two years as an associate chemist at Merck Process Research where he worked on the development of selective COX-II inhibitors. Afterwards, he moved to Harvard University where he obtained his Ph.D. in organic chemistry from Professor David A. Evans. His doctoral work focused on asymmetric catalysis using lanthanide-pybox complexes. He continued his studies as a postdoctoral fellow with Professor Barry M. Trost at Stanford University where he worked on the synthesis of indoline alkaloid communesin B. He joined the faculty of Dartmouth College in the summer of 2007.
Position: Assistant Professor of Chemistry
Address: Department of Chemistry, 6128 Burke Laboratories, Hanover, NH 03755
Synform Young Career Focus write-up on Jimmy Wu is published (Synform 2013, 4, A49)
Jimmy Wu is named a 2013 Thieme Chemistry Journal Awardee
Jimmy Wu is appointed a member of the Molecular Therapeutics Research Program (Dartmouth-Hitchcock Norris Cotton Cancer Center)
Jimmy Wu receives Research Scholar Grant from the American Cancer Society (RSG-13-011-01-CDD) - "Studies on the Nuphar Alkaloids - Powerful Apoptosis-Inducing Compounds" (Jan 2013 to Dec 2016)
Although sulfur-containing molecules are prominent in numerous areas of research, comparatively little effort has been devoted to their synthesis. Many well-known bioactive compounds, such as the β-lactam antibiotics (i.e. penicillins, cephalosporins, thienamycin), anti-inflammatory agents (i.e. Vioxx and Celebrex), H2-receptor antagonists (i.e. Tagamet, Zantac, Pepcid), biotin, lipoic acid, and glutathione contain sulfur. In fact, it has been demonstrated in several instances that replacing a carbon or oxygen atom with sulfur greatly enhances the bioactivity of certain compounds with respect to their oxygenated or carbon counterparts. Sulfur-containing compounds also play an important role in organic synthesis as they are useful intermediates in a wide range of diastereoselective and stereospecific transformations. Given the importance of sulfur in chemistry and biology, it is rather surprising that, in comparison to the amount of effort devoted to the discovery of new methods for preparing carbon−carbon, carbon−oxygen, and carbon−nitrogen bonds, considerably fewer resources have been allocated to the development of preparing carbon−sulfur bonds.
We have developed methods for constructing carbon-sulfur bonds by direct displacement of the corresponding alcohol and/or other oxygen-based leaving groups using catalytic Ga(OTf)3 or UV light. In particular, our laboratory has demonstrated that phosphorothioate esters are versatile functional groups that can be transformed into thiols, thioethers, and enantioenriched tetrahydrothiophenes. We have also shown that allylic phosphorothioate esters readily participate in transition metal-catalyzed cross-coupling reactions with a diverse range of Grignard reagents to furnish carbon-carbon bonds.
Last Updated: 5/10/13