Gordon W. Gribble
|Professor Gribble received his B.S. degree in Chemistry in 1963 from the University of California, Berkeley, and his Ph.D. in Organic Chemistry in 1967 from the University of Oregon. After spending a year at UCLA as a National Cancer Institute Postdoctoral Fellow, he joined the faculty of Dartmouth College in 1968. Dr. Gribble has been a National Institutes of Health Research Career Development Awardee (1971-76), a National Science Foundation Professional Development Awardee (1977-78), and an American Cyanamid Academic Achievement Awardee (1988). In 2005 he was named to the endowed Chair “The Dartmouth Professor of Chemistry.” He is the co-editor of “Progress in Heterocyclic Chemistry” and the co-author of “Palladium in Heterocyclic Chemistry.”
Position: Dartmouth Professor of Chemistry
E-Mail: Gordon W. Gribble
Research Group Web Site
Professor Gribble's research program covers several areas of organic chemistry, most of which involve synthesis, including novel indole chemistry, triterpenoid synthesis, DNA intercalation, and new synthetic methodology. Of prime interest is the synthesis of bis-acridines that act as DNA double intercalators, one of which is active against human glioblastoma cells. In the area of new synthetic methodology, Dr. Gribble and his students have discovered new chemistry of nitroindoles. A third area of research is the synthesis and biological activity of triterpenoids in the chemoprevention of cancer and other diseases related to inflammation. One of these synthetic triterpenoids, "bardoxolone methyl" has entered Phase 3 clinical trials for the treatment of chronic kidney disease in diabetes patients.
Dr. Gribble also has a deep interest in naturally occurring organohalogen compounds, and in the chemistry of wine and wine making.
- "Potential DNA Bis-Intercalating Agents. Synthesis and Antitumor Activity of N,N-Methylenedi-4,1-cyclohexanediyl-bis(9-acridinamine) Isomers"; Gribble, G.W.; Mosher, M.D.; Jaycox, G.D.; Cory, M.; Fairley, T.A. Heterocycles, 2013, in press.
- "Synthesis and Diels-Alder Reactions of Pyrrolo[3,4-b]indoles. A Synthesis of 4-Acetamidocarbazoles and an Approach to the Antiostatins"; Pelkey, E.T.; Jiang, J.; Gribble, G.W. Indian J. Chem. 2013, 90, in press.
- "Synthetic Approaches Towards the Marine Alkaloid Prenostodione"; Badenock, J.C.; Jordan, J.A.; Gribble, G.W. Tetrahedron Lett. 2013, 54, 2759-2762.
- "Efficient and Scalable Synthesis of Bardoxolone Methyl (CDDO-Methyl Ester)"; Fu, L.; Gribble, G.W. Org. Lett. 2013, 15, 1672-1675.
- "Food Chemistry and Chemophobia"; Gribble, G.W. Food Security: The Science, Sociology and Economics of Food Production and Access to Food 2013, 5,177-187.
- "Bruceolline J: 2-hydroxy-3,3-dimethyl-2,3-dihydrocyclopenta[b]indol-1(4H)-one"; Lopchuk, J.M.; Gribble, G.W.; Millikan, S.P.; Jasinski, J.P. Acta Cryst. 2013, E69, o1351-o1352.
- "A Short, Protecting Group-Free Total Synthesis of Bruceollines D, E, and J"; Lopchuk, J.M.; Green, I.; Badenock, J.C.; Gribble, G.W. Organic Lett. 2013, 15, 4485-4487.
- "Manganese(III)-mediated Oxidative Radical Addition of Malonates to 2-Cyanoindole"; Lopchuk, J.M; Montgomery, W.L.; Jasinski, J.P.; Gorjifard, S.; Gribble, G.W. Tetrahedron Lett. 2013, 54, 6142-6145.
- "What Controls the Regiochemistry in 1,3-Dipolar Cycloadditions of Münchnones with β-Nitrostyrenes?"; Lopchuk, J.M.; Hughes, R.P.; Gribble, G.W. Organic Lett. 2013, 15, 5218-5221.
- "Attachment at Ring Positions"; Gribble, G.W.; Fu, L.; Lin, Q-X., In Pyridines – From Lab to Production, Ed. Scriven, E.F.V, Elsevier, NY, 2013, 153-373.