Current Research

Zhenwu Zhuang, M.D.

Research Interests:

·       Molecular mechanism of post-angioplasty/stenting restenosis at the genetic level in rats or transgenic/knock-out mice; 

·       In vivo monitoring restenosis and remodeling in small animal using an advanced image technique (MR microscopy);

·       Image reconstruction for computed tomography (micro-CT and CT) about arteriogenesis in infarct heart and ischemic hindlimb;

·       CT perfusion study;

·       Link between vascular structure and physiological function;

·       Development of micro-interventional procedures for angiogenesis and molecular imaging research;

·       Liver neoplasm chemotherapy and embolization in small animal tumor model; 

·       Transjugular intrahepatical portosystemic shunt (TIPS) for portal hypertension; 

·       Photodynamic therapy for cardiovascular disease;

·       Drug local delivery;

·       New contrast agent.

New Images and Technology in Angiogenesis/Arteriogenesis

Micro-angiography in KO mice

Post-mortem angiography in Rat treated with fresh bone marrow cells

3D computed tomographic angiography (CTA) in rat treated with fresh bone marrow cells 2 weeks post ligation of the right femoral artery


Selected Publications:

Chapters:
1. Zhuang ZW, Wang ZM. Intravascular Stents.IN Li LS, ed. Clinical Interventional Therapy.Jiangsu Scientific and Technological Publishing House, Nanjing, 1994. [Chinese]

2. Zhuang ZW. Stenting.IN Li LS, ed. Interventional Radiology.  Chinese Scientific and Technological Publishing House, Beijing, 1999. [Chinese]
3. Li LS, Zhuang ZW. Endovascular Stents. IN Yang ZB, ed. Biomedical Engineer.Heilongjiang Scientific and Technological Publishing House, 2000. [Chinese]

Papers:
1. Zhang SQ, Zhuang ZW, Li SY, et al. Contrast pleurography and localized sclerotherapy pulmonary bulla. Chin J Radiol 1994; 28(5): 307-312. [Chinese]
2. Zhuang ZW. Imaging diagnosis and strategy of pulmonary embolization. Foreign Medical Sciences 1995: 18(3): 150-154. [Chinese]
3. Zhuang ZW, Li LS, Wang J, Feng YL, Shi HB.Post-resection recurrence of liver cancer and interventional therapy. Chin J Radiol 1996; 30(6): 410-414. [Chinese]
4. Zhuang ZW. New advance of imaging guided percutaneous ethanol injection therapy of hepatocellular carcinoma. Chin J Med Imag Tech 1997; 13 (suppl): 28. [Chinese] [Review]
5. Zhuang ZW, Li LS, Gao YD. A preliminary experimental study of US-guided percutaneousintrahepatic acetic acid injection. ActaAcademiaeMedicinaeNanjing 1997; 17(5): 457-461. [Chinese]
6. Zhuang ZW, Gao YD, Li LS. Us-guided intratumoral acetic acid injection therapy for liver tumors in rats. Chin J Hepato, 6 (3):157-159, 1998. [Chinese]
7.Zhuang ZW, Li, LS, Gao YD. A comparative study of ultrasound-guidedintratumoral acetic acid and ethyl injection therapy for liver tumors in rats. Journal of NanjingMedicalUniversity, 12(1):28-33, 1998.
8. Liu XH, Liu JL, Zhuang ZW, Li LS. Forty-two patients with Takayasuarteritis: Clinical, Laboratory and angiographic studies. ActaAcademiaeMedicinaeNanjing, 19(1):34-38, 1999.
9. Zhuang ZW. Biodegradable polymer stents. Foreign Medical Sciences, 22(6):682-703, 1999. [Chinese] [Review]
10.d’Othee BJ, Black WC, Pirard S, Zhuang Z, Bettmann MA. Decision analysis in radiology. J Radiol 2001; 82:1693-1698.
11. d’Othee BJ, Bettmann MA, Pirard S, Zhuang Z, Black WC. Cost-effectiveness and cost-utility evaluations in radiology. J Radiol 2001; 82: 1687-1692.
12. Zhuang ZW, Bettmann MA, Hoopes JP, Koutras PC, Ebbighausen WH, Wagner RJ. Transjugular intrahepatic portosystemic shunt with an autologous vein graft-covered stent: result in a swine model. J Vas IntervRadiol, 12(11):1333-1342, 2001.
13. Zhuang ZW, Teng GJ, Jeffery RF, Gemery J, d’Othee BJ, Bettmann MA. Long-term results in patients with TIPS: an outcome study. AJR, 179(6): 1597-1603, 2002

Abstracts:
1. Zhuang ZW, Bettmann MA, Hoopes JP, Koutras PC, Ebbighausen WH, Wagner RJ. Transjugularintrahepaticportosystemic shunt with an autologous vein graft covered stent in a swine model: A pilot study. 2000 Research Initiatives Conference in vascular disease, 62, 2000.
2. Zhuang ZW, Bettmann MA, Hoopes JP, Koutras PC, Ebbighausen WH, Wagner RJ.Transjugularintrahepaticportosystemic shunt with an autologous vein graft-covered stent: result in a swine model. J Vas IntervRadiol 2000; 11(2 Suppl II):259, 2000.
3. Zhuang ZW, Bettmann MA, Hoopes JP, Koutras PC, Wagner RJ, Zeltmann L. Preventing intimal hyperplasia in transjugularintrahepaticportosystemic shunt with photodynamic therapy: A pilot study. J Vas IntervRadiol 2000; 11(2 Suppl II):451-452.
4. Zhuang ZW, Bettmann MA, Teng GJ, Jeffery RF, Langdon DR. Lone-term results in patients with TIPS: an outcome study. J Vas IntervRadiol 2001; 12(2 Suppl I), S9-10.
5. Zhuang ZW, Sato K, Mandinov L, Maciag T, Simons M, Post MJ. Effect of Jagged and soluble on intimal hyperplasia in a rat carotid artery injury model. Circulation (suppl) 2002; 106 (19): II-125.
6. Zhuang ZW, Bettmann MA, Simons M, Moodie K, de Muinck ED. Effect of North-Jagged pathway on intimal hyperplasia in a rat carotid artery injury model. JVIR (suppl) 2003; 14(2):S66.
7. Khurana R, Zhuang ZW, Bhardwaj S, et al. Adventitial angiogenesis drive neointima formation. Circulation (suppl) 2003; 108(17)IV-171.
8.Zhuang ZW, Gao L, Murakami M, Haque S, Sackett T, Muinck ED. 3D CT Angiography Technique for assessment of arteriogenesis in the rat hindlimb ischemia model. JACC (suppl) 2004; 43(5): 319A.
9. Mandinov L, Moodie KL, Mandinova A, Zhuang Z,Maciag T, Simons, M, de Muinck ED. Inhibition of in-stentrestenosis in Porcine Coronary Arteries by Copper Chelation. JACC (suppl) 2004; 43(5): 78A.
10. Zhuang ZW, Hoopes JP, Weinstein SJ, Bettmann MA. Quantitation of neointima by Intravascular Ultrasound and Histomorphologyin a porcine TIPS with an Autologous Vein Covered Stent. JVIR (suppl) 2004;

If you have comments or suggestions, please mail me at zzw@dartmouth.edu

All rights reserved. Last modified: Apr. 8, 2004.