About The Lab

Our lab research is neuroscience-oriented. The overriding theme targets the cellular and molecular mechanisms of neurotransmitter receptor interactions and their plasticity in the adult and developing CNS. Our laboratory incorporates behavioral, neuroanatomical, patch clamp electrophysiological and molecular biological techniques to reveal and investigate coordinated adaptive changes in neuronal function, morphology, gene and protein expression. Such changes may become manifest as a result of acute or chronic insult during development, aging, in response to drugs of abuse or neurotoxicants. Ongoing research projects employ a variety of transgenic mouse models to investigate: (1) neurotrophins and the development of inhibitory and excitatory synaptic transmission; (2) neurotransmitters as developmental signals in the migration, specification and functional maturation of neurons; (3) cellular and molecular mechanisms in the septum and hippocampus that link enhanced spatial learning and memory with transgenically induced conditional gain of NGF function; (4) cellular and molecular mechanisms underlying the learning and memory deficits in chronic alcoholism. Graduate students and postdoctoral fellows are encouraged to elaborate on these research themes and cross-fertilize them with their own interests.

 

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