Our Research


Lab Members

Genetics Department

MCB Graduate Program



Bazari, W., Matsudaira, P., Wallek, M., Smeal, T., Jakes, R., and Ahmed, Y. (1988).  Villin sequence and

peptide map identify six homologous domains.  Proc. Natl. Acad. Sci. USA 85: 4986–4990. PubMed


Ahmed, Y. F., Hanly, S. M., Malim, M. H., Cullen, B. R., and Greene, W. C. (1990). Structure- function

analyses of the HTLV-I Rex and HIV-1 Rev RNA response elements: insights into the mechanism

of Rex and Rev action.  Genes & Dev.4:1014–1022. PubMed


Ahmed, Y. F., Gilmartin, G. M., Hanly, S. M., Nevins, J. R., and Greene, W. C. (1991). The HTLV-I Rex

response element mediates a novel form of mRNA polyadenylation. Cell 64: 727–737. (Featured in

Cell 64: 671-4). PubMed


Greene, W. C., Hanly, S. M., Rimsky, L. T., and Ahmed, Y. F. (1991). Molecular analysis of the type I

human T cell leukemia virus rex gene, in Viruses That Affect the Immune System, ed. H. Fan

(Washington, D. C.:  American Society for Microbiology).


Bogerd, H. P., Huckaby, G. L., Ahmed, Y. F., Hanly, S. M., and Greene, W. C. (1991). The type I human

T-cell leukemia virus (HTLV-I) Rex trans-activator binds directlyto the HTLV-I Rex and the type 1

human immunodeficiency virus Rev RNA response elements.  Proc. Natl. Acad. Sci. USA 88:

5704-5708. PubMed


Ahmed, Y., Hayashi, S., Levine, A., and Wieschaus, E. (1998). Regulation of Armadillo by a Drosophila

APC inhibits neuronal apoptosis during retinal development. Cell 93, 1171-1182. PubMed


Ahmed, Y., Nouri, A., and Wieschaus, E. (2002). Drosophila Apc1 and Apc2 regulate Wingless

transduction throughout development. Development 129, 1751-1762. (Cover Article). PubMed


Takacs, C.M., Baird, J.R., Hughes, E.G., Kent, S.S., Benchabane, H., Paik, R., and Ahmed, Y (2008).

Dual positive and negative regulation of Wingless signaling by Adenomatous polyposis coli.

Science 319: 333-336. Abstract  Full Text


Benchabane, H., Hughes, E.G., Takacs, C.M., Baird, J.R., and Ahmed, Y. (2008). Adenomatous polyposis

coli is present near the minimal level required for accurate graded responses to the Wingless

morphogen. Development 135: 963-971. (Cover Article). PDF


Ogden SK, Fei DF, Schilling NS, Ahmed YF, Hwa J, Robbins DJ (2008).  G protein Gai functions

 immediately downstream of Smoothened in Hedgehog signaling. Nature 456: 967-970. PubMed


Benchabane, H., and Ahmed, Y. (2009). The Adenomatous polyposis coli tumor suppressor and Wnt

signaling in the regulation of apoptosis, Adv Exp Med Biol 656, 75-84.  Also published in APC proteins,

ed. I. Nathke and B. McCartney (Austin, TX: Landes Bioscience), pp. 75-84. Landes


Benchabane H, Xin N, Tian A, Hafler BP, Nguyen K, Ahmed A, and Ahmed Y (2011). Jerky/Earthbound

Facilitates Cell-Specific Wnt/Wingless Signaling by Modulating -catenin-TCF Activity.

EMBO J 30: 1444-1458. Abstract


Xin  N, Benchabane H, Tian A, Nguyen K, Klofas L and Ahmed Y (2011). Erect Wing Facilitates

Context-Dependent Wingless Signal Transduction by Recruiting the Cell-Specific Armadillo-TCF

Adaptor Earthbound to Chromatin. Development 138: 4955-4967. PDF


Busch A, Johnson KC, Stan RV, Ahmed Y, Dmitrovsky E, and Freemantle S (2013). Evidence for Tankyrases

as neoplastic targets in lung cancer. BMC Cancer 13: 211. Abstract


Tacchelly-Benites O, Wang Z, Yang E, Lee  E, and Ahmed Y (2013). Toggling a Conformational Switch

in Wnt/β-catenin Signaling: Regulation of Axin Phosphorylation. Bioessays 35, in press.  Abstract


Chen TW, Wallace HA, Ahmed Y, and Lee E (2014). Wnt signal transduction in the cytoplasm:

an introduction to the destruction complex. In Wnt signaling in Development and Disease: Molecular

Mechanisms and Biological Functions, ed. S Hoppler and R. Moon (Oxford, UK: Wiley Publishers), in press.