Tim Yahr CV

CURRICULUM VITAE OF TIMOTHY L. YAHR

BIOGRAPHICAL INFORMATION
Date and place of birth:	November, 1967 West Bend, Wisconsin, USA
Citizenship:	U.S.
Marital Status:	Married
Work Address:	Department of Biochemistry Dartmouth Medical School Hanover, NH 03755
Email:	Timothy.Yahr@Dartmouth.edu
Telephone and Fax:	TEL: (603) 650-1701 FAX: (603) 650-1353

EDUCATION

University of Wisconsin-Stevens Point, Stevens Point, Wisconsin B.S., Biology, May, 1991.
Medical College of Wisconsin, Milwaukee, Wisconsin. M.S., Microbiology, December, 1995.
Medical College of Wisconsin, Milwaukee, Wisconsin Ph.D., Microbiology, August, 1998.

PROFESSIONAL EXPERIENCE

Postdoctoral Fellow July 1998-present
Department of Biochemistry
Dartmouth Medical School, Hanover, New Hampshire

Laboratory Technologist June 1991-August 1994
Department of Microbiology
Medical College of Wisconsin, Milwaukee, Wisconsin

TEACHING EXPERIENCE

Tutor for Medical Microbiology Fall Semester 1996

MEMBERSHIPS IN PROFESSIONAL SOCIETIES

American Society for Microbiology 1992-present

PATENTS

Frank, D. W., Yahr, T. L., Sawa, T., and Wiener-Kronish, J. 1998. Method of and composition for immunization with the Pseudomonas V antigen.

AWARDS AND RESEARCH GRANTS

National Research Service Award 1999-2001
Sustaining Member Student Travel Grant Award 1998
American Society for Microbiology

Scholarship and Fellowship 1994-1998
Medical College of Wisconsin

Student Travel Award 1995-1998
Graduate Student Association
Friends of the Medical College of Wisconsin

Pseudomonas Club Graduate Student Award Best Abstract 1995
Genentech - Cystic Fibrosis Foundation
General Meeting of the American Society for Microbiology, Washington D.C.

Faculty Research Award 1991
University of Wisconsin - Stevens Point

Outstanding Microbiologist 1991
University of Wisconsin - Stevens Point

Student Research Fund Grant 1991
University of Wisconsin - Stevens Point

ABSTRACTS

Holder, I. A., Neely, A. N., Yahr, T. L., and Frank, D. W. 1999. Genetic analysis of the type III effectors of P. aeruginosa in the burned mouse model. General Meeting of the American Society for Microbiology, Chicago, IL.

Yahr, T. L., Vallis, A. J., Hancock, M. K., and D. W. Frank. 1998. ExoY, a novel type III secreted adenylate cyclase from Pseudomonas aeruginosa. General Meeting of the American Society for Microbiology, Atlanta, GA.

Vallis, A. J., Yahr, T. L., Barbieri, J. T., and D. W. Frank. 1998. Contact-mediated regulation of ExoS production by Pseudomonas aeruginosa. General Meeting of the American Society for Microbiology, Atlanta, GA.

Finck-Barbancon, V., Yahr, T. L., and D. W. Frank. 1998. Characterization of the exoU locus from Pseudomonas aeruginosa. General Meeting of the American Society for Microbiology, Atlanta, GA.

Ohara, M., Sawa, T., Kurahashi, K., Yahr, T. L., Frank, D. W., Wiener-Kronish, J. P., and M. A. Gropper. 1998. Pseudomonas aeruginosa inhibits Fc receptor-mediated phagocytosis. American Federation for Biomedical Research, Biomedicine, 1998.

Sawa, T., Ohara, M., Kurahashi, K., Yahr, T. L., Gropper, M. A., Frank D. W., and J. P. Wiener-Kronish. 1998. Pathogenesis of acute lung injury caused by Pseudomonas aeruginosa- major contribution of type III secretory system. American Federation for Biomedical Research, Biomedicine, 1998.

Yahr, T. L., Vallis, A. J., Friese, M. B., Mende-Mueller, L. M., and D. W. Frank. 1997. Identification and characterization of type III secreted products of the Pseudomonas aerguinosa exoenzyme S regulon. Midwest Microbial Pathogenesis Meeting, Ann Arbor, MI.

Vallis, A. J., Yahr, T. L., and D. W. Frank. 1997. Development of in vitro methodologies to study type III-mediated translocation of Pseudomonas aeruginosa ExoS . Midwest Microbial Pathogenesis Meeting, Ann Arbor, MI.

Yahr, T. L., Friese, M. B., Mende-Mueller, L. M., and D. W. Frank. 1997. Pseudomonas aeruginosa encodes homologs to the Yersinia lcrGVHyopBD locus. General Meeting of the American Society for Microbiology, Miami Beach, FL.

Liu, S., Knight, D. A., Yahr, T. L., and J. T. Barbieri. 1996. Biochemical properties of the 53-kDa form of Pseudomonas aeruginosa exoenzyme S. General Meeting of the American Society for Microbiology, New Orleans, LA.

Yahr, T. L., Goranson, J., and D. W. Frank. 1996. Exoenzyme S of Pseudomonas aeruginosa is secreted by a type III secretion pathway. General Meeting of the American Society for Microbiology, New Orleans, LA. Gordon Conference on Microbial Toxins and Pathogenesis, Colby-Sawyer College, NH.

Yahr, T. L., Barbieri, J. T., and D. W. Frank. 1995. The genetic relationship between the 49- and 53-kDa forms of exoenzyme S. General Meeting of the American Society for Microbiology, Washington, D.C.

Yahr, T. L. and D. W. Frank. 1994. Transcriptional analysis of the exoenzyme S structural gene. Gordon Conference on Microbial Toxins and Pathogenesis, Colby-Sawyer College, NH.

Yahr, T. L. and D. W. Frank. 1992. Transcriptional organization of the exoenzyme S trans-regulatory locus in Pseudomonas aeruginosa. General Meeting of the American Society for Microbiology, Atlanta, GA.

Hovey, A. K., Yahr, T. L., and D. W. Frank. 1992. Functional analysis of ExsA of Pseudomonas aeruginosa. General Meeting of the American Society for Microbiology, Atlanta, GA.

Yahr, T. L. and D. W. Frank. 1992. Transcriptional control of the trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa. Gordon Research Conference on Microbial Toxins and Pathogenesis, Colby-Sawyer College, NH.

PUBLICATIONS

Yahr, T. L., and William Wickner. 2000. The oligomeric state of SecYEG in preprotein translocase. Manuscript in preparation.

Olson, J. C., Fraylick, J. E., McGuffie, E. M., Dolan, K. M., Yahr, T. L., Frank, D. W., and T. S. Vincent. 1999. Interruption of multiple cellular processes in HT-29 epithelial cells by Pseudomonas aeruginosa exoenzyme S. Infect. Immun. 67:2847-2854.

Sawa, T., Yahr, T. L., Ohara, M., Kurahashi, K., Gropper, M. A., Wiener-Kronish, J. P., and D. W. Frank. 1999. Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury. Nature Med. 5:392-398.

Vallis, A. J., Finck-Barbancon, V., Yahr, T. L., and D. W. Frank. 1999. Biological effects of Pseudomonas aeruginosa type-III secreted proteins on CHO cells. Infect. Immun. 67:2040-2044.

Vallis, A. J., Yahr, T. L., Barbieri, J. T., and D. W. Frank. 1999. Regulation of ExoS production and secretion by Pseudomonas aeruginosa in response to tissue culture conditions. Infect. Immun. 67:914-920.

Finck-Barbancon, V., Yahr, T. L., and D. W. Frank. 1998. Identification and characterization of SpcU, a chaperone required for efficient secretion of the ExoU cytotoxin. J. Bacteriol. 180:6224-6231.

Yahr, T. L., Vallis, A. J., Hancock, M. K., Barbieri, J. T., and D. W. Frank. 1998. ExoY, an adenylate cyclase secreted by the Pseudomonas aeruginosa type III system. Proc. Nat. Acad. Sci. USA 95:13899-13904.

Yahr, T. L., Mende-Mueller, L. M., Friese, M. B., and D. W. Frank. 1997. Identification of type III secreted products of the Pseudomonas aeruginosa exoenzyme S regulon. J. Bacteriol. 179:7165-7168.

Liu, S., Yahr, T. L., Frank, D. W., and J. T. Barbieri. 1997. Biochemical relationships between the 53 (Exo53) and 49 (ExoS) kDa forms of exoenzyme S of Pseudomonas aeruginosa. J. Bacteriol. 179:1609-1613.

Yahr, T. L., Goranson, J., and D. W. Frank. 1996. Exoenzyme S of Pseudomonas aeruginosa is secreted by a type III pathway. Mol. Microbiol. 22:991-1003.

Yahr, T. L., Barbieri, J. T., and D. W. Frank. 1996. Genetic relationship between the 53- and 49-kDa forms of exoenzyme S from Pseudomonas aeruginosa. J. Bacteriol. 178:1412-1419.

Yahr, T. L., Hovey, A. K., Kulich, S. M., and D. W. Frank. 1995. Transcriptional analysis of the Pseudomonas aeruginosa exoenzyme S structural gene. J. Bacteriol. 177:1169-1178.

Yahr, T. L. and D. W. Frank. 1994. Transcriptional organization of the trans-regulatory which controls exoenzyme S synthesis in Pseudomonas aeruginosa. J. Bacteriol. 176:3832-3838.

Kulich, S., Yahr, T. L., Mende-Mueller, L., Barbieri, J. T., and D. W. Frank. 1994. Cloning the structural gene of the 49 kDa form of exoenzyme S (exoS) from Pseudomonas aeruginosa strain 388. J. Biol. Chem. 269:10431-10437.

<< go back