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Bioactive Small Molecules from Lactic Acid Bacteria for Prevention of HIV-1 in Adults and Infants

Probiotics are live microorganisms which, when administered in adequate amounts, confer a health benefit to the host. Probiotics most commonly include strains of lactic acid bacteria within the genera of Lactobacillus and Bifidobacteria. Ingestion of live probiotic bacteria has been associated with an improvement in intestinal and immune health when consumed on a regular basis.

Dartmouth researchers have now developed culture and fractionation methods that yield small bioactive molecules (500-700 Da) secreted by the lactic acid bacterium Lactobacillus rhamnosus GG. The molecules are hydrophilic, heat stable, acid stable, and resistant to proteolytic enzymes. Furthermore, the molecules decrease HIV replication in susceptible target cells and tissues; decrease secretion of inflammatory immune mediators such as IL-1ra, IL-6, and IL-8; decrease secretion of vasoendothelial growth factor; and decrease activation of cell signaling through Erk1/Erk2 pathways. Given their potent activity, these molecules find application as topical microbicides for preventing HIV transmission in both adults and infants.

This technology is claimed in the published PCT Application No. PCT/US2009/036451. We are seeking an industrial partner interested in its commercialization. (Ref: J448)

Last Updated: 7/24/12