Coronary collateral circulation has been recognized as an alternative source of blood supply to an ischemic myocardial area. Collateral artery formation is associated with smaller infarcts, less ventricular aneurysm formation, improved ventricular function, fewer future cardiovascular events and improved survival.
Dartmouth researchers have now found that there is a strong positive correlation between increases in the presence or formation of collateral arteries and N-terminal probrain natriuretic peptide (NT-pro-BNP) or brain natriuretic peptide (BNP) levels. Therefore, NT-pro-BNP and its processed product, BNP, are useful surrogate serum biomarkers for collateral formation and measuring NT-pro-BNP or BNP levels could be useful for monitoring the effectiveness of angiogenic therapy and identifying individuals in need of such treatment.
This technology is claimed in the published United States Patent Application No. 12/402,759. We are seeking an industrial partner interested in its commercialization. (Ref: J279)
Last Updated: 7/24/12