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Technology Transfer Office
11 Rope Ferry Road #6210
Hanover, NH 03755-1404
Phone: (603) 646-3027
Fax: (603) 646-3670

Nicotinamide Riboside Kinases and Their Uses for Prodrug Development

Dartmouth scientists have discovered two human genes encoding nicotinamide riboside kinases that are highly specific for activation of a class of anti-cancer, anti-viral and immunosuppressive prodrugs related to tiazofurin. These genes and their encoded enzymes are useful for drug development and for identifying patients who may be susceptible to treatment with a prodrug related to tiazofurin.

These findings are claimed in the published United States Patent Application Nos. 11/542,832, 11/912,400, and 12/411,586 as well as several pending and published foreign applications. We are seeking an industrial partner to further refine and market this technology. (Ref: J263)

Last Updated: 7/24/12