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We have developed a new system
which, for the first time, makes it feasible to measure pO2 in the clinical
setting with the accuracy, sensitivity, and repeatability needed for
effective clinical use. The method
measures at defined sites in the region(s) of interest and measurements can
be made simultaneously at several sites.
The existing methods for making experimental measurements of pO2 in
cells and tissues, e.g., the Clark electrode, fluorescence quenching, O2
binding to myoglobin, chemiluminescence, phosphorescence quenching, and spin
label oximetry are useful but have certain limitations, especially when used in vivo. None of these techniques appears to have the
potential for making repeated measurements in the clinical setting. Our method, on the other hand,
is particularly advantageous for clinical measurements of oxygen in tissues in vivo. Once the material used to measure pO2 is
injected into the tissue of interest or applied non-invasively, pO2 can be
measured conveniently, rapidly, and repetitively in a NON-INVASIVE MANNER
with a device designed and constructed at The availability of a method
to make sensitive, accurate, and repeated measurements of the pO2 in tissues
would be of great clinical significance, especially for the optimization of
cancer therapy and for aiding in the diagnosis and treatment of vascular
disease. In clinical oncology such
measurements are likely to be used initially to determine the presence of a
high degree of hypoxia, in order to plan an optimum approach for that
tumor. Subsequent measurements will
enable the therapeutic oncologist to monitor the response of the pO2 of the
tumor to the initial therapeutic regime, in order to decide whether the
therapy should be modified. In
peripheral vascular disease this technique will permit the repeated
non-invasive assessment of the pO2 in the target tissues, providing an
objective measure of the course of the disease and the response to medical
and surgical therapy. This would be of
particular value in the care of diabetics and others with impaired
circulation to their legs and feet. There are a number of other
potential clinical applications as well, for any other diseases in which the
level of oxygen in the tissues would provide clinically useful information
(e.g. any disease involving impaired circulation or ischemia). As a consequence, the proposed system could
become a part of every well equipped hospital, especially in the oncology and
cardiovascular sections of the hospital.
This could involve the placement of 1 to 10 of these instruments in
virtually every hospital that treats patients with these types of diseases. There also is a considerable
commercial potential for the development of the system for experimental
purposes. The capabilities provided
by our system could be of significant value for a wide range of experimental
studies in small and large animals. These studies would include not only
those with direct link to the clinical areas described above, but also for a
wide range of studies of basic biology and physiology, because of the
importance of oxygen concentrations in most physiological and
pathophysiological processes. The feasibility of The apparatus, methodology,
and non-invasive approach are claimed in the issued We are seeking an industrial partner who can participate
in the refinement of this approach into a device suitable for routine
clinical use and is interested in commercialization of this technology. (Ref: J55) |
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«Technology Transfer Office : Sponsored Projects : Dartmouth College |
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11 Rope Ferry Road #6210 |
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Hanover, NH 03755-1404 |
Phone: (603) 646-3027 |
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Fax: (603) 646-3670 |
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