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Dartmouth
researchers have now developed culture and fractionation methods that yield small
bioactive molecules (500-700 Da) secreted by the lactic acid bacterium Lactobacillus rhamnosus GG. The
molecules are hydrophilic, heat stable, acid stable, and resistant to
proteolytic enzymes. Furthermore, the molecules decrease HIV replication in susceptible
target cells and tissues; decrease secretion of inflammatory immune mediators
such as IL-1ra, IL-6, and IL-8; decrease secretion of vasoendothelial growth
factor; and decrease activation of cell signaling through Erk1/Erk2 pathways.
Given their potent activity, these molecules find application as topical
microbicides for preventing HIV transmission in both adults and infants.
This technology is claimed in
the published PCT Application No. PCT/US2009/036451. We are seeking an
industrial partner interested in its commercialization. (Ref: J448)
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