Regulatory T Cell MEDIATOR PROTEINS and uses thereof
Technologies Available for License Standard Agreements Invention Disclosure Invention Agreement Dartmouth Policies Trademark Program Annual Reports Related Sites		Regulatory T cells (T^reg) play an important role in constant and inducible control of T cells responses in vitro and in vivo. T^reg cell depletion results in the induction of autoimmune pathology and exacerbation of T cells responses to foreign and self-antigens, including heightened anti-tumor responses as well as ablation of transplantation tolerance and rapid graft rejection. Dartmouth researchers have now found a novel member of the PD-L1 family expressed by T^reg cells. This novel protein has been designated PD-L3. Like other members of the PD-L1 family, PD-L3 co-stimulates αCD3 proliferation of T cells in vitro. In addition, the expression of PD-L3 is increased in αCD3-activated T^reg and reduced in the presence of αGITR. A second, TNF-like, protein has also been identified as being upregulated upon αCD3/αGITR stimulation. This protein has been designated T^reg-sTNF. These proteins may be involved in contact-dependent and paracrine suppression of immunity and can therefore be used to modulate immune responses and treat diseases and conditions involving T^reg signaling. This technology is claimed in a pending patent application. We are seeking an industrial partner interested in its commercialization. (Ref: J269)

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