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NICOTINAMIDE RIBOSIDE KINASES

AND THEIR USES

FOR PRODRUG DEVELOPMENT

 

 

 

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Dartmouth scientists have discovered two human genes encoding nicotinamide riboside kinases that are highly specific for activation of a class of anti-cancer, anti-viral and immunosuppressive prodrugs related to tiazofurin.  These genes and their encoded enzymes are useful for drug development and for identifying patients who may be susceptible to treatment with a prodrug related to tiazofurin. 

 

These findings are claimed in the published United States Patent Application Nos. 11/542,832, 11/912,400, and 12/411,586 as well as several pending and published foreign applications.  We are seeking an industrial partner to further refine and market this technology. (Ref: J263)

 

 

«Technology Transfer Office : Sponsored Projects : Dartmouth College

 

11 Rope Ferry Road #6210

E-Mail: technology.transfer@dartmouth.edu

Hanover, NH 03755-1404

Phone: (603) 646-3027

 

 

 

Fax: (603) 646-3670