December 2010

Dartmouth Receives $2 Million Grant for Children's Health Research Center

Dartmouth recently received a $2 million pilot grant to fund the new Children's Environmental Health and Disease Prevention Center at Dartmouth. The grant is jointly funded by the United States Environmental Protection Agency (EPA) and the National Institute for Environmental Health Sciences (NIEHS). Dartmouth's is one of six emerging centers nationally that are undertaking interdisciplinary research to assist public health professionals and policy makers in combating children's diseases caused by environment pollutants.

To read more click here

Dartmouth Researchers Collaborate with MDIBL to Study Callahan Mine Superfund Site

"The study involves both staff and visiting scientists to the MDI [Mt. Desert Island Biological Laboratory] including researchers from College of the Atlantic, Dartmouth College and Indiana University. It is being conducted under the Dartmouth College Superfund Program, which has conducted studies at other Superfund sites, funded through grants from the National Institute of Environmental Health Sciences."

To read more click here

November 2010

Dartmouth Researcher Honored with 2010 NIEHS Karen Wetterhahn Award

Dartmouth researcher Courtney Kozul-Horvath, PhD, is the recipient of the 2010 Karen Wetterhahn Memorial Award, which was presented November 12, 2010, at the National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program Annual Meeting in Portland, Oregon.

Kozul-Horvath was cited for her work with Joshua Hamilton, PhD, and Bruce Stanton, PhD, at Dartmouth Medical School, as part of the Dartmouth Toxic Metals Superfund Research Program examining the harmful effects of constant environmental exposure to arsenic in drinking water at or below the U.S. Environmental Protection Agency's standard of 10 parts per billion.

Kozul-Horvath demonstrated that low-level arsenic exposure in mice significantly impaired the immune response in the lung, which led to increased morbidity following influenza infection.

Karen Wetterhahn was a chemistry professor at Dartmouth College and the founder of the Dartmouth Toxic Metals Superfund Research Program. Shortly after her tragic death in 1997, the NIEHS began presenting an award in her memory to recognize an outstanding graduate student or post-doctoral researcher that best exemplifies the qualities exhibited by Dr. Wetterhahn.

Full Story

Courtney Kozul-Horvath, a Dartmouth Superfund Researcher, wins award for poster at the Dartmouth College Post Doc Association Annual Research Symposium

Courtney won first place for her poster entitled "Immunotoxicity of Developmental Arsenic Exposure" at the Dartmouth College Post Doc Association Annual Research Symposium held on November 2nd at the Top of the HOP.

October 2010

Dartmouth Superfund Researcher, Jennifer Bomberger, receives Young Investigator Basic Science Award

Jennifer Bomberger, PhD, received the "Young Investigator Basic Science Award" at the North American Cystic Fibrosis Conference in Baltimore, MD on October 23rd, 2010. Dr. Bomberger, a fellow in the Stanton Laboratory in the Center for the Environmental Health Sciences at Dartmouth studies how arsenic activates the ubiquitin-lysosomal degradation of CFTR and thereby reduces lung mucociliary clearance and the innate immune response to bacterial and viral infections.

REGISTRATION NOW OPEN: LEAD SYMPOSIUM

Dartmouth College presents the first LEAD (Leadership, Equality, And Diversity) symposium this October 28-29th at Dartmouth College. The goal of this symposium is to provide an opportunity for students, postdoctoral fellows, employees, interns/residents, junior and senior faculty and community members to learn more about the current issues facing women in science and medicine. The symposium is free, and we encourage both men and women to attend.

The symposium will feature keynote speeches delivered by women from across the country, as well as career development and training workshops, Q&A, and breakout sessions with a variety of scientific professionals from Dartmouth, New England, and beyond.

Check out the website at http://www.dartmouth.edu/~leadsymposium10 more information, including how to register for particular sessions, a finalized schedule, and specific locations for events.

Contact PhD/MD student Crissy Megli with any questions. Christina.J.Megli@dartmouth.edu

Faculty of 1000 Biology selects study by Dartmouth Superfund Researchers as one of the top 2% of biological sciences papers

A recent study by Dartmouth Superfund researchers has been selected by the Faculty of 1000 Biology as one of the top 2% of articles from among the wealth of literature published in the biological sciences. The study "Gene response profiles for Daphnia pulex exposed to the environmental stressor cadmium reveals novel crustacean metallothioneins" by Shaw JR, Colbourne JK, Davey JC, Glaholt SP, Hampton TH, Chen CY, Folt CL, and Hamilton JW was published in BMC Genomics 2007 Dec 21 8(1):477 http://f1000biology.com/article/id/1097571.

According to the Faculty of 1000 "Using a cDNA microarray and taking advantage of the growing Daphnia genomic database, the authors have identified three different genes induced by exposure to low ambient cadmium at environmentally relevant concentrations, putatively encoding metal-binding proteins, metallothioneins (MTs).

Interestingly, these three Daphnia MT genes cluster in one group when aligned with other crustacean and insect MTs, so they most likely result from recent duplications, rather than from paralogs present in the ancestor of cladocerans and insects. The comparison also illustrates how extremely variable metallothionein genes are, outside conserved positions of cysteines. The new Daphnia MTs, which are described here for the first time in a non-malacostracan crustacean, are rather remote from crab and lobster MTs. This confirms recent evolutionary analyses, which place Branchiopoda separate from Malacostraca in a sister group of Hexapoda.

Indiana University researcher awarded $2.27 million to study environmental effects on gene copy number

The National Institute of Environmental Health Sciences has awarded $2.27 million to Indiana University researcher Joseph Shaw for a five-year study of how the environment alters genetic information through mutation and natural selection.

The project reflects a changing approach to environmental science, which is increasingly incorporating advances in molecular toxicology, computational sciences andinformation technology to learn how environmental factors produce genetic changes that influence health risks.

The grant builds on past training and support for Shaw's research career. He was an NIEHS Fellow while in graduate school at the University of Kentucky and an NIEHS-funded postdoctoral researcher with the Dartmouth College Superfund Research Program. He has since 2004 been a summer research associate at Mt. Desert Island Biological Laboratory in Maine, and he came to IU Bloomington in 2007 with support from IU's Commitment to Excellence program, which funded the creation of faculty positions for research across its schools and departments in environmental sciences.

For full article click here

September 2010

Katrina's Floods Dropped Children's Lead Levels

The floods that inundated New Orleans five years ago during Hurricane Katrina may have left behind a small silver lining for some families.

The fresh layer of sediment deposited by the floods buried contaminated soils and led to a drop in soil lead levels in some heavily contaminated neighborhoods. That led to a dramatic drop in the blood lead levels of children living there, according to a recent study published in Environmental Science and Technology.

For full article: http://news.discovery.com/human/katrina-lead-levels-children.html

Dartmouth Superfund Researcher, Tom Hampton, presented a paper at the 5th Aquatic Animal Models for Human Disease Conference.

The conference took place on September 20th-22nd at Portland State University in Corvallis, Oregon. The title of the paper was "Intuitive Microarray Analysis: Implications for complex systems."

For more information about the conference please visit:

http://oregonstate.edu/conferences/event/aamhd2010/

C-MERC Workshop

On September 8-10, 2010, over 50 mercury researchers, policy-makers and stakeholders from around the globe gathered in Portsmouth, New Hampshire to address the challenges of identifying current marine mercury science, both what is known and the gaps in knowledge, and of integrating that science with current questions relating to mercury policy world-wide. During this first workshop of the Coastal and Marine Mercury Ecosystem Research Collaborative (C-MERC), multiple papers were outlined on mercury in specific ocean systems, as well as papers on current global issues in the mercury field. It is anticipated that these papers and the resulting translation products will advance our understanding of mercury as a global contaminant, and will support international policy decisions related to mercury in the environment.

For more information about the workshop vist www.c-merc.org

Seminar: Arsenic on Your Plate

Professor Andrew Meharg of the University of Aberdeen, Scotland will present the seminar on Thursday, September 23, 2010 at 4:30pm in Filene Auditorium, Moore Hall. Professor Meharg, Author of Venomous Earth, the compelling story of arsenic-contaminated well water in Bangladesh which has caused devastating affects on human health, will discuss the occurrence of arsenic in food. He will focus specifically on arsenic in rice, an issue with global significance, and one which is currently being examined by researchers in Dartmouth's Toxic Metals Superfund Research Program. He will also provide a brief overview of his book.

http://thedartmouth.com/2010/9/24/news/arsenic

Bruce A. Stanton, Ph.D., an acclaimed researcher and educator on the environmental triggers of disease, has been appointed to the Andrew C. Vail Memorial Professorship at Dartmouth Medical School (DMS)

This endowed professorship was established by Mary W. McGaw in 1973, in memory of her grandson, and in support of the research interests of exemplary Dartmouth Medical School faculty members. The appointment is effective as of July 1, 2010.

Dr. Stanton has been a professor at DMS since 1993. He is Director of the Dartmouth Toxic Metals Superfund Research Program, the Environmental Health Sciences Center and the Lung Biology Center. Dr. Stanton arrived at Dartmouth in 1984 from Yale University, where he earned both his M.S. and Ph.D. in physiology, did postdoctoral work, and was Associate Research Scientist in the Department of Physiology.

Dr. Stanton is an active teacher and researcher, has made invited presentations at numerous institutes and scientific meetings, and is author or co-author of several of the seminal textbooks on physiology. His research interests are integrative genomics and proteomics of cystic fibrosis, host-pathogen interactions in cystic fibrosis, cystic fibrosis drug discovery, and the effects of environmental exposure of arsenic on human disease. Dr. Stanton is the P.I. for several major NIH and foundation research and training grants.

For full press release click here

August 2010

Dartmouth Superfund Researcher, Jason Moore, has been appointed the Third Century Professorship at Dartmouth Medical School

Jason H. Moore, Ph.D., is appointed to the Third Century Professorship at Dartmouth Medical School, effective July 1, 2010. This endowed professorship was established by the Trustees of Dartmouth College to recognize excellence in teaching and scholarship, and to enable the incumbent to develop and implement major experiments in teaching and education. The previous holder was James Weinstein, D.O.

At Dartmouth, Dr. Moore is currently Professor of Genetics and of Community and Family Medicine, Director of Bioinformatics for DMS, and founder and director of multiple centers, including, notably, the DISCOVERY parallel-processing computing resource. He has adjunct appointments at UVM, Brown, and UNH. Dr. Moore arrived at Dartmouth in 2004 from Vanderbilt University, where he was Associate Professor of Molecular Physiology and Biophysics, as well as the Ingram Associate Professor of Cancer Research. He earned his Ph.D. in Human Genetics from the University of Michigan.

Dr. Moore is an active teacher and researcher, and has made invited presentations at numerous institutes and scientific meetings, including, most recently, Indiana's Center for Computational Biology and Bioinformatics and the Fred Hutchinson Cancer Research Center's Program in Computational Biology. His research interests are developing, evaluating, and applying novel computational and statistical algorithms for identifying combinations of DNA sequence variations along with combinations of environmental factors that are predictive of common disease endpoints. Dr. Moore is the P.I. for several major research and training grants, and has worked closely with the departments of Genetics and Community and Family Medicine to launch graduate and post-graduate training programs in quantitative biomedical sciences.

LEAD Symposium on Women in Science

The LEAD (leadership, equality and diversity) symposium on women in science and medicine will take place on the Dartmouth Medical School campus from 6pm October 28-5pm October 29. Please mark your schedules and calendars for this important and exciting event. The symposium will consist of large lecture sessions, as well as workshops, panel sessions and small group sessions.

This symposium is generously funded by Dartmouth Medical School, Dartmouth Office of Graduate Studies, HHMI Dartmouth Undergraduate Science Education Program, and the COBRE Center for Lung Biology.

iPhone app helps people tackle the challenge of discovering what seafood is safe for consumption

People who want to make a difference often ask, “What can I do?” Because most people's main relationship with the ocean is through the seafood we eat, knowing about sustainable seafood is one of the things we can do. So to help lighten our load on the ocean, Blue Ocean Institute has created an iPhone app called FishPhone http://www.blueocean.org/fishphone.

See Full Article: "http://carlsafina.org/2010/08/16/%E2%80%9Cwhat-can-i-do%E2%80%9D-try-blue-ocean%E2%80%99s-new-iphone-app/

July 2010

Dartmouth Superfund researcher, Margaret Karagas comments on a study published in Lancet entitled "Arsenic exposure from drinking water, and all-cause and

chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study

Millions of people worldwide are chronically exposed to arsenic through drinking water, including 35–77 million people in Bangladesh. The association between arsenic exposure and mortality rate has not been prospectively investigated by use of individual-level data. We therefore prospectively assessed whether chronic and recent changes in arsenic exposure are associated with all-cause and chronic-disease mortalities in a Bangladeshi population.

CNN Article

Lancet Article

Karagas' Comment

June 2010

High levels of toxic metals, such as arsenic, cadmium and lead, found in protein drinks

According to the following excerpt from the July 2010 issue of Consumer Reports magazine protein drinks contain toxic metals and be a potential health hazard.

"Some protein drinks can even pose health risks, including exposure to potentially harmful heavy metals, if consumed frequently. All drinks in our tests had at least one sample containing one or more of the following contaminants: arsenic, cadmium, lead, and mercury. Those metals can have toxic effects on several organs in the body."

For more information visit: http://www.consumerreports.org/cro/magazine-archive/2010/july/food/protein-drinks/overview/index.htm

NH LAKES 2010 LAKES CONGRESS

"Lake Management and Protection in Action."
Friday, June 25, 2010
8:00 AM - 3:30 PM
Squam Lakes Natural Science Center
23 Science Center Road ● Holderness, New Hampshire

The New Hampshire Lakes Association (NH LAKES) cordially invites you to attend the 2010 Lakes Congress on Friday, June 25, 2010, at the Squam Lakes Natural Science Center in Holderness, New Hampshire, just steps away from beautiful Squam Lake.

The theme of the 2010 Lakes Congress is “Lake Management and Protection in Action.” This seventeenth Lakes Congress offers an excellent opportunity for lake enthusiasts, lake association members, state agency personnel, researchers, lake and watershed management professionals, and political leaders to exchange information, ideas, and experiences as well as to introduce new approaches, products, and services to help us all work together to better manage and protect lakes and ponds.

For more information visit: http://www.nhlakes.org/Lakes-Congress-Registration-2010.aspx

Related website: http://www.hubbardbrookfoundation.org/article/view/14775/1/2259

Annual Meeting Dates Confirmed

Mark your calendars! The dates for the 2010 SRP Annual Meeting have been confirmed. The meeting will be held in Portland, OR, on November 11-12. Research Translation Core and Outreach Core satellite meetings will be held on the 10th. Stay tuned for more information in the coming weeks.

David Salt, a co-PI on the Dartmouth Superfund grant, Project #9 recently co-authored a paper in Nature magazine

The paper, entitled "Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines" is a genome wide association study on Arabidopsis. To read the paper use the link below.

http://www.nature.com/nature/journal/v465/n7298/pdf/nature08800.pdf

28th Annual New England Membrane Enzyme Group Meeting

Marine Biological Laboratory, Woods Hole MA, October 7-9, 2010

NUTMEG is a regional toxicology and pharmacology meeting with typically 70-100 participants. Originally focused on cytochrome P450s and other membrane-bound xenobiotic enzymes, it has expanded over the years to encompass a wide variety of toxicology and pharmacology areas from cell and molecular, to physiological to epidemiological, translational and outreach aspects of toxicology and pharmacology, focusing in particular on the effects of environmental agents on human health. Since 2007, this meeting has also served as the annual regional meeting of New England's three NIH-NIEHS Superfund Basic Research Programs at Boston University, Brown, and Dartmouth.

McDonald's recalls 'Shrek' glasses due to cadmium

Toxic cadmium has been discovered in the painted design on "Shrek"-themed drinking glasses being sold nationwide at McDonald's, forcing the fast food company to recall 12 million of the U.S.-made collectibles.

Link to article

May 2010

Celia Chen a researcher in the Dartmouth Superfund Program will present an e Learning Web Seminar entitled "Bioaccumulation and Trophic Transfer of Mercury in Aquatic Food Webs"

The Superfund Research Program announces the latest Risk e Learning Web seminar: Using Ecological-Based Tools and Approaches to Assess Bioavailability. This seminar is the second in the "Ecological Risk: New Tools and Approaches" ReL Series (more seminars will be added soon).

This Web seminar will feature Dr. Kim Andersion, Professor, Oregon State University and Dr. Celia Chen, Research Associate Professor, Dartmouth College. Dr. Anderson's presentation "Biological Response Indicator Devices for Gauging Environmental Stressors (BRIDGES)", will demonstrate the sensitivity of the BRIDGES bio-analytical tool for detecting spatially distinct toxicity in aquatic systems; bridging environmental exposure to biological response.

Dr. Chen's presentation "Bioaccumulation and Trophic Transfer of Mercury in Aquatic Food Webs", will cover work conducted in both freshwater and estuarine ecosystems through a combination of field and experimental studies that investigated the factors that influence the trophic transfer of methylmercury from the bottom of the food web up to fish that humans consume. The seminar will be on June 30th from 1:30 to 3:30.

For more information visit: http://www.niehs.nih.gov/research/supported/srp/events/riskelearning/index.cfm

Dartmouth Superfund Researcher, Carol Folt, Appointed Provost

President Jim Yong Kim announced today that he has appointed Carol L. Folt as Dartmouth's Provost effective immediately.

Folt has served as Acting Provost since October 2009 when she replaced Provost Barry P. Scherr, who served for eight years in this role. Folt has also continued to serve as dean of the faculty of Arts & Sciences, a position she has held since 2004. A member of the Dartmouth faculty since 1983, she holds an endowed faculty position as The Dartmouth Professor of Biological Sciences. A search will be launched for a new dean of faculty immediately and Folt will step down from her position as dean as soon as a new dean is selected.

In making the announcement, President Kim said, "Carol is an internationally recognized scientist, an outstanding educator, and an astute and visionary administrator. She commands great respect within and outside Dartmouth for her ability to identify broad goals and implement them with a deep commitment to academic excellence, and with creativity and integrity.

Link to full press release: http://www.dartmouth.edu/~news/releases/2010/05/05.html

Dartmouth Students Design Filter To Save Lives From Arsenic Poisoning

The Green Blog, a blog on Boston.com published the following article:

I've written about a naturally occurring arsenic belt in New England that may be putting thousands of families' private drinking water supplies at risk from central Maine to central Massachusetts.

But that potential contamination pales compared to arsenic poisoning taking place everyday in Bangladesh, Nepal and other South Asian countries. Every year tens of thousands of people become sickened when arsenic in rock seeps into drinking water supplies. Skin lesions can appear on people and skin and internal cancers can occur.

For full article click the link below: http://www.boston.com/lifestyle/green/greenblog/2009/11/dartmouth_students_design_filt_1.html#comments-open-text

Superfund Researcher, Jason Moore, to speak at NIEHS

Dr. Moore will be speaking on Gene-Environment Interactions at NIEHS on May 27th at NIEHS. More information to follow.

New Papers Published by Superfund Researchers

Superfund Researcher Celia Chen and her research associates have published two new papers. Links to the papers are below.

Reduced Trace Element Concentrations in Fast-Growing Juvenile Atlantic Salmon in Natural Streams
http://www3.interscience.wiley.com/journal/123359490/abstract?CRETRY=1&SRETRY=0

Metal (As, Cd, Hg, and CH3Hg) bioaccumulation from water and food by the benthic amphipod Leptocheirus plumulosus http://pubs.acs.org/doi/abs/10.1021/es902639a

Studies aim to resolve confusion over mercury risks from fish

Research identifies riskier fish and ways to limit potentially harmful exposures. The way it boosts neural development in babies and protects the hearts and minds of adults, fish could be considered a health food. Yet the methylmercury pollution that taints fish worldwide can erase these advantages and even trigger profound mental and cardiovascular harm. Several new papers now suggest strategies by which American diners can negotiate the mercury minefield to tap dietary benefits in fish.

For full article click here

How to Make Sustainable Seafood Choices at the Fish Market

The seafood we eat has an enormous impact on our health today and the health of our oceans tomorrow. Article published in Eating Well discussing how to make good choices when purchasing seafood.

Click here to read more.

April 2010

Risk Assessment 101 Presented on April 6, 2010

On April 6, 2010, the RTC held a free, one-day Risk Assessment 101 workshop for its researchers, trainees and invited stakeholders from partnering agencies. Over 20 participants had high praise for the event, led by nationally recognized risk assessor, Dr. Charles Menzie, who was invited to cover the basic principles and application of risk assessment for Hazardous Waste and Superfund Sites in the Northeast U.S., from both a human health and ecological perspective.

Dr. Menzie provided an interactive overview of the risk assessment process, up-to-date risk assessment information, and tailored his talk to fit the attendees' different backgrounds and varying levels of expertise in risk assessment. The design of the workshop also allowed for networking between program researchers and stakeholders and created the potential for future collaboration. The presentation will be available online in the near future.

Dartmouth Researcher, Celia Chen, will be presenting her research at the University of South Carolina and Woods Hole Marine Biological Laboratory in April.

The title of Celia's presentation is "Ecological factors controlling Hg bioaccumulation and trophic transfer in aquatic food webs".

Schedule of presentations: April 9th: Invited seminar at University of South Carolina
April 27th: Invited seminar at Woods Hole Marine Biological Laboratory.

Inaugural Partnerships for Environmental Public Health Program Meeting April 26 & 27, 2010 at Research Triangle Park, North Carolina

Research Translation Coordinator, Laurie Reynolds Rardin is excited to attend the upcoming Inaugural Partnerships for Environmental Public Health Program Meeting where she will make important connections with other public health research professionals. Dartmouth Superfund member Nancy Serrel will be participating on one of the panels.

The Partnerships for Environmental Public Health Program (PEPH) is conceived of as umbrella program which will bring scientists, community members, educators, health care providers, public health officials, and policy makers together in the shared goal of advancing the impact of science-based inquiries of environmental health threats of concern to communities on local, regional, and national levels. By coordinating new and existing opportunities for support of environmental public health research and dissemination over the next decade, NIEHS will continue to lead efforts to protect the health of groups that are disadvantaged by exposure to occupational or environmental hazards.

Program and Registration

NH DES's Drinking Water Source Protection Workshop will be held on April 30th in Concord

This year's annual workshop for local officials concerning how to protect local water supplies will be held on Friday April 30th at the Grappone Center in Concord, NH from 8:45 am - 3:30 pm. This workshop has become the largest state-organized drinking water "source protection" event in New England as more people become involved in protecting their local source of drinking water.

Registration

Dartmouth Superfund researcher, Jason Moore, is featured on the cover of the Spring issue of Dartmouth Medicine.

Computational geneticist Jason Moore believes that more is needed to parse the human genome than simply more data.He has devised new ways to visualize genetic patterns. He built a supercomputer to crunch statistics faster.

Full Article

Arsenic in apple juice: How much is too much?

Dartmouth Researcher Joshua Hamilton is quoted in this article from the St. Petersburg Times.

Every school day across the Tampa Bay area and America, kids leave home with apple juice in their lunch boxes. Their toddler siblings drink it from sippy cups.

The labels look kid-friendly: Motts, Apple & Eve Organics, Tree Top.

But what's inside those boxes may not be completely benign.

Independent testing commissioned by the St. Petersburg Times has found levels of arsenic that have caught the attention of scientists and parents.

More than a quarter of the 18 samples tested by the Times contained between 25 and 35 parts per billion of arsenic — amounts that surpass the Food and Drug Administration's "level of concern" for heavy metals in juices.

Full Article

March 2010

Program Director, Bruce Stanton, will be a guest speaker at the 2010 ECFS conference - New Frontiers in Basic Science of Cystic Fibrosis, Carcavelos, Portugal, April 7-10, 2010.

Dr. Stanton will be presenting a talk entitled "Tobramycin and FDA-approved iron chelators eliminate P. aeruginosa biofilms on cystic fibrosis airway epithelial cells" at the 2010 ECFS conference - New Frontiers in Basic Science of Cystic Fibrosis, Carcavelos, Portugal, April 7-10, 2010.

For more information: http://www.ecfs.eu/carcavelos2010

Dartmouth Researcher, Celia Chen, will be speaking as part of the Agency for Toxic Substances and Disease Registry Seminar Series

One of the core goals of the Superfund Research Program is the translation of basic scientific research advances into regulatory, industrial, and public health practice. These outreach efforts include partnering with other federal agencies to communicate research findings, provide networking and collaboration opportunities, and discuss needs for future work. In October 2007, Dr. Fred Pfaender, of the UNC-CH SRP, presented a seminar to the Agency for Toxic Substances and Disease Registry (ATSDR) in Atlanta, GA. The seminar, "Bioavailability as a Factor in Pollutant Exposure," was so well received that a full series of seminars was launched in 2008.

For 2010, four SRP grantees will give seminars and then spend lunch and the afternoon discussing mutual research and applied environmental health interests with NCEH/ATSDR scientists. All 2010 seminars will be held: Wednesday 10 – 11:30 am, Building 106 Rooms 1A/1B, National Center for Environmental Health Agency for Toxic Substances & Disease Registry, Centers for Disease Control & Prevention, Chamblee Campus, 4770 Buford Highway NE, Atlanta, GA 30341-3717.

  • September 15, 2010 — Celia Y Chen, Ph.D., Dartmouth College. Ecological Factors Controlling Metal Bioaccumulation and Trophic Transfer in Aquatic Food Webs

For more information: http://www.niehs.nih.gov/research/supported/srp/about/about6_s7.cfm

DMS team identifies new cancer on-ramp

Dartmouth researchers report finding a new pathway with which the environmental toxin arsenic may trigger cancer of the bladder, lungs, and skin. They unveiled results of their study http://cancerres.aacrjournals.org/cgi/rapidpdf/0008-5472.CAN-09-2898v1 on February 23 in Cancer Research, a journal of the American Association for Cancer Research (AACR).

“In a collaborative investigation, we found that arsenic, at environmentally relevant levels, is capable of activating the Hedgehog pathway and may represent a novel pathway of arsenic-associated diseases, such as bladder cancer,” says epidemiologist and coauthor Margaret R. Karagas, Ph.D., a professor in the Department of Community and Family Medicine at Dartmouth Medical School (DMS) and codirector of the Cancer Epidemiology and Chemoprevention Research Program at Dartmouth's Norris Cotton Cancer Center (NCCC). “We provide important insight into the etiology of arsenic-induced disease, potentially relevant to the millions of people worldwide who are exposed to arsenic.”

For full article click here

February 2010

Dartmouth Video Highlights Arsenic Risks, Solutions for Wells

The Dartmouth Toxic Metals Research Program premiered a new short film, In Small Doses: Arsenic, at a gathering at Red River Theatres in Concord, N.H., for officials of local, state, and federal environmental and health agencies, state lawmakers, and members of the regional media. The movie encourages owners of private wells in northern New England to check the levels of arsenic in their drinking water.

In addition to explaining the science behind arsenic contamination, and identifying areas of New Hampshire, Vermont and Maine with the highest concentrations of arsenic, the 10-minute video [See http://www. InSmallDoses.org or http://www.youtube.com/watch?v=hi5DfRy01vE] discusses relatively inexpensive ways for well-owners to test and treat their water.

“We have been working with our state and regional partners on this issue for more than a decade,” said Bruce Stanton, Ph.D., director of the toxic metals program and a DMS professor of physiology. “We are all concerned that it's 2010 and still most private well owners are not testing, in spite of concrete evidence that wells in New Hampshire contain potentially high and harmful levels of arsenic if ingested over long periods of time.”

To read the full story click here: http://www.concordmonitor.com/apps/pbcs.dll/article?AID=/20100212/FRONTPAGE/2120313

To watch the movie: http://www.youtube.com/watch?v=hi5DfRy01vE

For more news click here

January 2010

Dartmouth Superfund Researcher, Tracy Punshon, Presents in March at the 239th American Chemical Society National Meeting and Exposition in San Francisco, California

Tracy will be presenting her paper entitled "Use of synchrotron x-ray fluorescence microscopy in plant functional genomics" as part of a special session on Synchrotron work during the March 21-25 Conference.

The following is a brief summary of Tracy's paper: "We used synchrotron x-ray fluorescence (SXRF) in raster scanning and computed microtomography modes to analyze the cellular and sub-cellular distribution of metal(loid)s in plant tissues, as a way of characterizing the function of genes involved in metal ion homeostasis in plants. We conducted high resolution analysis on embedded, thick-sectioned (5 µm) seed, finding contrasts in the Fe distribution between wild type (Col-0) and a mutant lacking the vacuolar iron transporter gene VIT1 [figure 1]. We have begun to analyze fresh hypocotyl tissue from two-week old agar-grown Arabidopsis plants using SXRF-CM, which involves overcoming constraints from sample drying during data collection. Analyses were conducted at X26A of the National Synchrotron Light Source, 2-ID-D of the Advanced Photon Source and BL2-3 of the Stanford Synchrotron Radiation Laboratory. We will discuss the use of SXRF and XAS in plant functional genomics."

For more information on the meeting click here: Spring 2010 National ACS Meeting and Exposition

New Hampshire Birth Cohort Study (NHBCS), a Dartmouth Superfund Research Project, Adds a Fourth Clinic Site in Concord

The New Hampshire Birth Cohort Study (NHBCS), a Dartmouth Superfund Research project under the leadership of Margaret Karagas, PhD, is pleased to announce the addition of a fourth clinic site, Concord OB/GYN Professional Associates in Concord, New Hampshire. The NHBCS is enrolling pregnant women from New Hampshire regions reported to have high well-water concentrations of arsenic. The study is investigating the effects of exposure to environmentally relevant levels of metals in food and water on birth outcomes. Since its launch in December 2009, NHBCS has enrolled pregnant women in Concord-area clinics, including Family Health Center and Concord Women's Care at Concord Hospital and Dartmouth-Hitchcock Concord.

The study focuses specifically on arsenic in drinking water and mercury in seafood. It will also measure exposure to other metals in order to better understand their potential interactions with arsenic and mercury in a developing fetus. Participants are asked to complete self-administered lifestyle, diet, and medical history questionnaires. They are also asked to submit well water, hair, nail (infant and maternal), urine, blood, cord blood, meconium, and placenta samples that will be used to assess metal exposure.

Two Dartmouth Professors Become Fellows of the American Association for the Advancement of Science

The American Association for the Advancement of Science (AAAS) has elevated two Dartmouth professors to the rank of Fellow. Jay Dunlap and Carol Folt are among the 531 new Fellows named in December. Dunlap is a Dartmouth Medical School professor, chair of genetics and a professor of biochemistry. Folt is The Dartmouth Professor of Biological Sciences, acting provost, and dean of the faculty.

Both Dunlap and Folt were elected Fellows by their peers as part of the section on biological sciences. Dunlap was recognized for outstanding contributions to the genomics of the fungus Neurospora, in particular the genes involved in its circadian system and circadian clock control of cell behavior.Folt was honored for her groundbreaking limnological work on salmon restoration and conservation, and on metal toxicity in aquatic ecosystems and implications for human health. She was also recognized for advancing scientific education and literacy as dean of the faculty at Dartmouth. All new Fellows will be honored in February during the 2010 AAAS Annual Meeting in San Diego, Calif.

To read the full story click here: http://www.dartmouth.edu/~news/releases/2010/01/06.html

New finding may lead to a new therapeutic approach to CF

The research paper entitled, "Tobramycin and FDA-approved iron chelators eliminate Pseudomonas aeruginosa biofilms on cystic fibrosis cells," Am J Respir Cell Mol Biol, Sep 41(3):305-13, 2009 written by Drs. Sophie Moreau-Marquis, George O'Toole and Bruce Stanton, has been identified by the Faculty of 1000 Medicine, which identifies and evaluates the most important articles published in medicine based on the recommendations of a faculty of over 2000 peer-nominated leading researchers and clinicians. The review of the significance of the research can be found at: http://www.f1000medicine.com/article/syg8t06x9kx4nv2/id/1168219.

You may also view the press release from Dartmouth Medical School here: http://dms.dartmouth.edu/news/2010/01/06_stanton.shtml

Dr. Jason Moore on NHPR's The Exchange to discuss "A New Age of Genetic Testing"

Dartmouth Superfund researcher, Jason Moore, was recently a guest on New Hampshire Public Radio, and the topic of discussion was genetic testing. Humans now have the ability to learn massive amounts of health information from their own genomes. The knowledge contained inside can tell us what we may be like in the future, who we're genetically compatible with, and what health hazards await us down the road. The conversaton on the complex science and ethical choices involved in reading our genetic maps led to interesting discussion and call-in questions from listeners.

For more information visit NPR at: http://www.nhpr.org/node/28155