Professor of Pharmacology and Medicine
Michael Sporn has been Professor of Pharmacology and Medicine at Dartmouth Medical School since 1995. Before that, he was Chief of the Laboratory of Chemoprevention at the National Cancer Institute from 1978 till moving to Dartmouth. His research interests over the years have been in the fields of nucleic acid research, studies of the chemistry and biology of retinoids, studies of peptide growth factors (particularly transforming growth factor-beta, TGF-beta), and most importantly, the chemoprevention of cancer. After moving to Dartmouth, he established a new collaboration with Professor Gordon Gribble in the Department of Chemistry at Dartmouth. Together with Dr. Gribble and Associate Professor Tadashi Honda, who have synthesized several hundred new synthetic triterpenoids, they have tested these agents for potential application in prevention and treatment of disease. These new agents have anti-inflammatory, anti-proliferative, pro-apoptotic, and cytoprotective activities. One of these triterpenoids, CDDO-Methyl ester, is now in Phase II trials for treatment of pancreatic cancer. The cellular and molecular mechanisms of action of the triterpenoids are being investigated in the Sporn Laboratory.
View Michael Sporn’s complete C.V.
Contact Information
7650 Remsen
Dept. of Pharmacology and Toxicology
Dartmouth Medical School
Hanover NH 03755
Office: Remsen 524A
Phone: 603-650-6557
Fax: 603-650-1129
Email: michael.sporn@dartmouth.edu
Asst. Phone: 603-650-6559
Principal Investigator
Research Assistant Professor
Postdoctoral Fellows
Graduate Students
Research Assistants
Renee Risingsong, B.S.
Administrative Assistant
Other Information
