Mark Michael Yore, B.Sc.

Mark Yore is a third year PhD candidate in the Sporn Lab. He received his B.Sc. (Hons) in Biotechnology and graduate diploma in Information Technology from Dublin City University, Dublin, Ireland. Prior to joining the Sporn Lab he worked for Icon Clinical Research, Dublin, Ireland and conducted medical research at Dartmouth College. His current work encompasses discovering molecular targets of synthetic triterpenoids and deciphering their mechanisms of action.

Contact Information

Mark Yore

Department of Pharmacology and Toxicology

Dartmouth Medical School

HB7650

Hanover

NH 03755

Phone: 603-650-6558

Fax: 603-650-1129

Publications

Liby K, Hock T, Yore MM, Suh N, Place AE, Risingsong R, Williams CR, Royce DB, Honda T, Honda Y, Gribble GW, Hill-Kapturczak N, Agarwal A, Sporn MB. The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling. Cancer Res. 2005 Jun 1;65(11):4789-98.

Stacey K. Ogden, David J. Casso, Manuel Ascano Jr., Mark M. Yore, Thomas B. Kornberg and David J. Robbins. Smoothened Regulates Activator and Repressor Functions of Hedgehog Signaling Via Two Distinct Mechanisms. J Biol Chem. 2006 (in press).

White KA, Yore MM, Deng D, Spinella MJ. (2005) Limiting effects of RIP140 in estrogen signaling: Potential mediation of anti-estrogenic effects of retinoic acid. J Biol Chem. 2005 Mar 4;280(9):7829-35. Epub 2005 Jan 4.

White KA, Yore MM, Warburton SL, Vaseva AV, Rieder E, Freemantle SJ, Spinella M (2003) Negative feedback at the level of nuclear receptor coregulation. Self-limitation of retinoid signaling by RIP140. J Biol Chem. 7;278(45):43889-92.