1: To C, Kulkarni S, Pawson T, Honda T, Gribble GW, Sporn MB, Wrana JL, Di

Guglielmo GM.

The Synthetic Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic

Acid-Imidazolide Alters Transforming Growth Factor {beta}-dependent Signaling and

Cell Migration by Affecting the Cytoskeleton and the Polarity Complex.

J Biol Chem. 2008 Apr 25;283(17):11700-13. Epub 2008 Feb 18.

PMID: 18283107 [PubMed - in process]

2: Osburn WO, Yates MS, Dolan PD, Liby KT, Sporn MB, Taguchi K, Yamamoto M,

Kensler TW.

Genetic or Pharmacologic Amplification of Nrf2 Signaling Inhibits Acute

Inflammatory Liver Injury in Mice.

Toxicol Sci. 2008 Apr 15; [Epub ahead of print]

PMID: 18417483 [PubMed - as supplied by publisher]

3: Dinkova-Kostova AT, Jenkins SN, Wehage SL, Huso DL, Benedict AL, Stephenson

KK, Fahey JW, Liu H, Liby KT, Honda T, Gribble GW, Sporn MB, Talalay P.

A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of

skin tumors in UV-irradiated mice.

Biochem Biophys Res Commun. 2008 Mar 21;367(4):859-65. Epub 2008 Jan 17.

PMID: 18206646 [PubMed - indexed for MEDLINE]

4: Vannini N, Lorusso G, Cammarota R, Barberis M, Noonan DM, Sporn MB, Albini A.

The synthetic oleanane triterpenoid, CDDO-methyl ester, is a potent

antiangiogenic agent.

Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3139-46. Epub 2007 Dec 7.

PMID: 18065492 [PubMed - indexed for MEDLINE]

5: Sporn MB.

A new tumor suppressor gene, selective for lung cancer.

J Natl Cancer Inst. 2007 Nov 21;99(22):1654-5. Epub 2007 Nov 13. No abstract

available.

PMID: 18000215 [PubMed - indexed for MEDLINE]

6: Koschmieder S, D'Alò F, Radomska H, Schöneich C, Chang JS, Konopleva M,

Kobayashi S, Levantini E, Suh N, Di Ruscio A, Voso MT, Watt JC, Santhanam R,

Sargin B, Kantarjian H, Andreeff M, Sporn MB, Perrotti D, Berdel WE, Müller-Tidow

C, Serve H, Tenen DG.

CDDO induces granulocytic differentiation of myeloid leukemic blasts through

translational up-regulation of p42 CCAAT enhancer binding protein alpha.

Blood. 2007 Nov 15;110(10):3695-705. Epub 2007 Aug 1.

PMID: 17671235 [PubMed - indexed for MEDLINE]

7: Thimmulappa RK, Fuchs RJ, Malhotra D, Scollick C, Traore K, Bream JH, Trush

MA, Liby KT, Sporn MB, Kensler TW, Biswal S.

Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im

and CDDO-Me) for protection from LPS-induced inflammatory response and reactive

oxygen species in human peripheral blood mononuclear cells and neutrophils.

Antioxid Redox Signal. 2007 Nov;9(11):1963-70.

PMID: 17822364 [PubMed - indexed for MEDLINE]

8: Liby K, Royce DB, Risingsong R, Williams CR, Wood MD, Chandraratna RA, Sporn

MB.

A new rexinoid, NRX194204, prevents carcinogenesis in both the lung and mammary

gland.

Clin Cancer Res. 2007 Oct 15;13(20):6237-43.

PMID: 17947492 [PubMed - indexed for MEDLINE]

9: Zou W, Chen S, Liu X, Yue P, Sporn MB, Khuri FR, Sun SY.

c-FLIP downregulation contributes to apoptosis induction by the novel synthetic

triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in

human lung cancer cells.

Cancer Biol Ther. 2007 Oct;6(10):1614-20. Epub 2007 Jul 19.

PMID: 18253090 [PubMed - indexed for MEDLINE]

10: Zou W, Chen S, Liu X, Yue P, Sporn MB, Khuri FR, Sun SY.

c-FLIP Downregulation Contributes to Apoptosis Induction by the Novel Synthetic

Triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in

Human Lung Cancer Cells.

Cancer Biol Ther. 2007 Jul 19;6(10) [Epub ahead of print]

PMID: 17923806 [PubMed - as supplied by publisher]

11: Liby K, Honda T, Williams CR, Risingsong R, Royce DB, Suh N, Dinkova-Kostova

AT, Stephenson KK, Talalay P, Sundararajan C, Gribble GW, Sporn MB.

Novel semisynthetic analogues of betulinic acid with diverse cytoprotective,

antiproliferative, and proapoptotic activities.

Mol Cancer Ther. 2007 Jul;6(7):2113-9.

PMID: 17620440 [PubMed - indexed for MEDLINE]

12: Fava RA, Elliott S, Raymond L, Mollmark J, Hays E, Honda T, Gribble GW, Sporn

MB, Vincenti MP.

The synthetic triterpenoid TP-222 inhibits RANKL stimulation of

osteoclastogenesis and matrix metalloproteinase-9 expression.

J Rheumatol. 2007 May;34(5):1058-68. Epub 2007 Mar 15.

PMID: 17361985 [PubMed - indexed for MEDLINE]

13: Liby KT, Yore MM, Sporn MB.

Triterpenoids and rexinoids as multifunctional agents for the prevention and

treatment of cancer.

Nat Rev Cancer. 2007 May;7(5):357-69. Epub 2007 Apr 19. Review.

PMID: 17446857 [PubMed - indexed for MEDLINE]

14: Honda T, Sundararajan C, Yoshizawa H, Su X, Honda Y, Liby KT, Sporn MB,

Gribble GW.

Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in

rings A and C: highly potent anti-inflammatory and cytoprotective agents.

J Med Chem. 2007 Apr 19;50(8):1731-4. Epub 2007 Mar 17.

PMID: 17367124 [PubMed - indexed for MEDLINE]

15: Liby K, Royce DB, Williams CR, Risingsong R, Yore MM, Honda T, Gribble GW,

Dmitrovsky E, Sporn TA, Sporn MB.

The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung

cancer induced by vinyl carbamate in A/J mice.

Cancer Res. 2007 Mar 15;67(6):2414-9.

PMID: 17363558 [PubMed - indexed for MEDLINE]

16: Burrage PS, Huntington JT, Sporn MB, Brinckerhoff CE.

Regulation of matrix metalloproteinase gene expression by a retinoid X

receptor-specific ligand.

Arthritis Rheum. 2007 Mar;56(3):892-904.

PMID: 17328062 [PubMed - indexed for MEDLINE]

17: Albini A, Sporn MB.

The tumour microenvironment as a target for chemoprevention.

Nat Rev Cancer. 2007 Feb;7(2):139-47. Review.

PMID: 17218951 [PubMed - indexed for MEDLINE]

18: Yates MS, Tauchi M, Katsuoka F, Flanders KC, Liby KT, Honda T, Gribble GW,

Johnson DA, Johnson JA, Burton NC, Guilarte TR, Yamamoto M, Sporn MB, Kensler TW.

Pharmacodynamic characterization of chemopreventive triterpenoids as

exceptionally potent inducers of Nrf2-regulated genes.

Mol Cancer Ther. 2007 Jan;6(1):154-62.

PMID: 17237276 [PubMed - indexed for MEDLINE]

19: Thimmulappa RK, Scollick C, Traore K, Yates M, Trush MA, Liby KT, Sporn MB,

Yamamoto M, Kensler TW, Biswal S.

Nrf2-dependent protection from LPS induced inflammatory response and mortality by

CDDO-Imidazolide.

Biochem Biophys Res Commun. 2006 Dec 29;351(4):883-9. Epub 2006 Oct 30.

PMID: 17097057 [PubMed - indexed for MEDLINE]

20: Honda T, Liby KT, Su X, Sundararajan C, Honda Y, Suh N, Risingsong R,

Williams CR, Royce DB, Sporn MB, Gribble GW.

Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of

new betulinic acid analogues having an enone functionality in ring A.

Bioorg Med Chem Lett. 2006 Dec 15;16(24):6306-9. Epub 2006 Sep 25.

PMID: 16996735 [PubMed - indexed for MEDLINE]

21: Yore MM, Liby KT, Honda T, Gribble GW, Sporn MB.

The synthetic triterpenoid

1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear

factor-kappaB activation through direct inhibition of IkappaB kinase beta.

Mol Cancer Ther. 2006 Dec;5(12):3232-9. Epub 2006 Dec 5.

PMID: 17148759 [PubMed - indexed for MEDLINE]

22: Liby K, Rendi M, Suh N, Royce DB, Risingsong R, Williams CR, Lamph W, Labrie

F, Krajewski S, Xu X, Kim H, Brown P, Sporn MB.

The combination of the rexinoid, LG100268, and a selective estrogen receptor

modulator, either arzoxifene or acolbifene, synergizes in the prevention and

treatment of mammary tumors in an estrogen receptor-negative model of breast

cancer.

Clin Cancer Res. 2006 Oct 1;12(19):5902-9.

PMID: 17020999 [PubMed - indexed for MEDLINE]

23: Liby K, Voong N, Williams CR, Risingsong R, Royce DB, Honda T, Gribble GW,

Sporn MB, Letterio JJ.

The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and

induces apoptosis in myeloma and lung cancer cells.

Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4288-93.

PMID: 16857804 [PubMed - indexed for MEDLINE]

24: Veronesi U, Mariani L, Decensi A, Formelli F, Camerini T, Miceli R, Di Mauro

MG, Costa A, Marubini E, Sporn MB, De Palo G.

Fifteen-year results of a randomized phase III trial of fenretinide to prevent

second breast cancer.

Ann Oncol. 2006 Jul;17(7):1065-71. Epub 2006 May 4.

PMID: 16675486 [PubMed - indexed for MEDLINE]

25: Sporn MB.

Dichotomies in cancer research: some suggestions for a new synthesis.

Nat Clin Pract Oncol. 2006 Jul;3(7):364-73. Review.

PMID: 16826217 [PubMed - indexed for MEDLINE]

26: Han SS, Peng L, Chung ST, DuBois W, Maeng SH, Shaffer AL, Sporn MB, Janz S.

CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and

plasma cell neoplasms.

Mol Cancer. 2006 Jun 7;5:22.

PMID: 16759389 [PubMed - indexed for MEDLINE]

27: Couch RD, Ganem NJ, Zhou M, Popov VM, Honda T, Veenstra TD, Sporn MB,

Anderson AC.

2-cyano-3,12-dioxooleana-1,9(11)-diene-28-oic acid disrupts microtubule

polymerization: a possible mechanism contributing to apoptosis.

Mol Pharmacol. 2006 Apr;69(4):1158-65. Epub 2006 Jan 11.

PMID: 16407469 [PubMed - indexed for MEDLINE]

28: Yates MS, Kwak MK, Egner PA, Groopman JD, Bodreddigari S, Sutter TR,

Baumgartner KJ, Roebuck BD, Liby KT, Yore MM, Honda T, Gribble GW, Sporn MB,

Kensler TW.

Potent protection against aflatoxin-induced tumorigenesis through induction of

Nrf2-regulated pathways by the triterpenoid

1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.

Cancer Res. 2006 Feb 15;66(4):2488-94.

PMID: 16489057 [PubMed - indexed for MEDLINE]

29: Sporn MB.

The early history of TGF-beta, and a brief glimpse of its future.

Cytokine Growth Factor Rev. 2006 Feb-Apr;17(1-2):3-7. Epub 2005 Nov 14. Review.

No abstract available.

PMID: 16290110 [PubMed - in process]

30: Sporn MB, Liby KT.

Cancer chemoprevention: scientific promise, clinical uncertainty.

Nat Clin Pract Oncol. 2005 Oct;2(10):518-25. Review.

PMID: 16205771 [PubMed - indexed for MEDLINE]

31: Hyer ML, Croxton R, Krajewska M, Krajewski S, Kress CL, Lu M, Suh N, Sporn

MB, Cryns VL, Zapata JM, Reed JC.

Synthetic triterpenoids cooperate with tumor necrosis factor-related

apoptosis-inducing ligand to induce apoptosis of breast cancer cells.

Cancer Res. 2005 Jun 1;65(11):4799-808.

PMID: 15930300 [PubMed - indexed for MEDLINE]

32: Liby K, Hock T, Yore MM, Suh N, Place AE, Risingsong R, Williams CR, Royce

DB, Honda T, Honda Y, Gribble GW, Hill-Kapturczak N, Agarwal A, Sporn MB.

The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of

heme oxygenase-1 and Nrf2/ARE signaling.

Cancer Res. 2005 Jun 1;65(11):4789-98.

PMID: 15930299 [PubMed - indexed for MEDLINE]

33: Couch RD, Browning RG, Honda T, Gribble GW, Wright DL, Sporn MB, Anderson AC.

Studies on the reactivity of CDDO, a promising new chemopreventive and

chemotherapeutic agent: implications for a molecular mechanism of action.

Bioorg Med Chem Lett. 2005 May 2;15(9):2215-9.

PMID: 15837296 [PubMed - indexed for MEDLINE]

34: Vázquez N, Greenwell-Wild T, Marinos NJ, Swaim WD, Nares S, Ott DE, Schubert

U, Henklein P, Orenstein JM, Sporn MB, Wahl SM.

Human immunodeficiency virus type 1-induced macrophage gene expression includes

the p21 gene, a target for viral regulation.

J Virol. 2005 Apr;79(7):4479-91.

PMID: 15767448 [PubMed - indexed for MEDLINE]

35: Dinkova-Kostova AT, Liby KT, Stephenson KK, Holtzclaw WD, Gao X, Suh N,

Williams C, Risingsong R, Honda T, Gribble GW, Sporn MB, Talalay P.

Extremely potent triterpenoid inducers of the phase 2 response: correlations of

protection against oxidant and inflammatory stress.

Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4584-9. Epub 2005 Mar 14.

PMID: 15767573 [PubMed - indexed for MEDLINE]