Publications

Caldwell, J. M., Chen, Y., Schollaert, K. L., Theis, J. F., Babcock, G. F., Newlon, C. S., and Sanchez, Y. Orchestration of the S-phase and DNA-damage checkpoint pathways by replication forks from early origins. J. Cell Biol., 2008, In press

Chen, Y., Pereira, E., and Sanchez, Y., Chk1. AfCS-Nature Molecule Pages (2007). (doi:10.1038/mp.a000642.01)

Searle, J. S. and Sanchez, Y. Dissecting layers of mitotic regulation essential for maintaining genomic stability.  Yeast as a tool in cancer research. Heitman, J., and Nitiss, J. L ed.  Springer, 2007

Poisson, J. M., Chen, Y. and Sanchez, Y. Transcription and genomic integrity. Gene Expression and Regulation, Ma, J. ed, Higher Education Press and Springer (Beijing)\, 2005

Chen Y and Sanchez Y. Chk1 in the DNA damage response: conserved roles from yeasts to mammals. DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1025-32.
PubMed ID: 15279789

Searle JS and Sanchez Y.  Stopped for Repairs: A new Role for Nutrient Sensing Pathways? Cell Cycle. 2004 Jul 17 [Epub ahead of print]
PubMed ID: 15190205

Schollaert KL, Poisson JM, Searle JS, Schwanekamp JA, Tomlinson CR, Sanchez Y.  A Role for Saccharomyces cerevisiae Chk1p in the Response to Replication Blocks. Mol Biol Cell. 2004 Sep;15(9):4051-63. Epub 2004 Jun 30.
PMID: 15229282

Rogoff HA, Pickering MT, Frame FM, Debatis ME, Sanchez Y, Jones S, Kowalik TF.   Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2.  Mol Cell Biol. 2004 Apr;24(7):2968-77.
PubMed ID: 15024084

Searle JS, Schollaert KL, Wilkins BJ, Sanchez Y. The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression.  Nat Cell Biol. 2004 Feb;6(2):138-45. Epub 2004 Jan 25.
PubMed ID: 14743219

Goudelock DM, Jiang K, Pereira E, Russell B, Sanchez Y.  Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex. J Biol Chem. 2003 Aug 8;278(32):29940-7. Epub 2003 May 19.
PubMed ID: 12756247

Jiang K, Pereira E, Maxfield M, Russell B, Goudelock DM, Sanchez Y.  Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345.  J Biol Chem. 2003 Jul 4;278(27):25207-17. Epub 2003 Apr 03.
PubMed ID: 12676962

Kuznetsova AV, Meller J, Schnell PO, Nash JA, Ignacak ML, Sanchez Y, Conaway JW, Conaway RC, Czyzyk-Krzeska MF.  von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination.  Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2706-11. Epub 2003 Feb 25.
PubMed ID: 12604794

Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ.  Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways.  Oncogene. 2002 Sep 26;21(43):6633-40.
PubMed ID: 12242661

Damia G, Sanchez Y, Erba E, Broggini M.DNA Damage Induces p53-dependent Down-regulation of hCHK1.  J Biol Chem. 2001 Apr 6;276(14):10641-5.
PubMed ID: 11152453

Conn CW, Hennigan RF, Dai W, Sanchez Y, Stambrook PJ.  Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3.  Cancer Res. 2000 Dec 15;60(24):6826-31.
PubMed ID: 11156373

Other Publications of Interest

Sanchez Y, Bachant J, Wang H, Hu F, Liu D, Tetzlaff M, Elledge SJ.  Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.  Science. 1999 Nov 5;286(5442):1166-71.
PubMed ID: 10550056

Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, Elledge SJ.  Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.  Science. 1997 Sep 5;277(5331):1497-501.
PubMed ID: 9278511

Sanchez Y, Zhou Z, Huang M, Kemp BE, Elledge SJ.Analysis of budding yeast kinases controlled by DNA damage.  Methods Enzymol. 1997;283:398-410.
PubMed ID: 9251037

Navas TA, Sanchez Y, Elledge SJ.  RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae.  Genes Dev. 1996 Oct 15;10(20):2632-43.
PubMed ID: 8895664

Sanchez Y, Desany BA, Jones WJ, Liu Q, Wang B, Elledge SJ.  Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways.  Science. 1996 Jan 19;271(5247):357-60.
PubMed ID: 8553072

Sanchez Y, Elledge SJ.  Stopped for repairs.  Bioessays. 1995 Jun;17(6):545-8.
PubMed ID: 7575496

Carrassa, L., Sanchez, Y., Erba, E., and Damia. G. U20S Cells Lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint. J Cell Mol Med., 2008. (Epub ahead of print).

Chen, Y., Caldwell, J.M., Pereira, E., Baker, R.W., and Sanchez, Y. 2009. ATRMec1 phosphorylation-independent activation of Chk1 in vivo. J. Biol.Chem., 284 (1), 182-190.

Pereira, E., Chen, Y. and Sanchez Y. Conserved ATRMec1 phosphorylation-independent activation of Chk1 by single amino acid substitution in the GD domain. Cell Cycle, 2009, In press.

Pereira, E., Solis, W. and Sanchez, Y. Chk2 . AfCS-Nature Molecule Pages (2009). In press