Publications

 

 Searle, J. S., Wood, M.,  Kaur, M., D. V. Tobin and Sanchez, Y.  Proteins in the nutrient sensing and DNA damage checkpoint pathways cooperate to restrain mitotic progression following DNA damage.  PLOS Genetics. 2011 Jul. 7(7): e1002176. [Epub ahead of print]. PubMed ID: 21779180

Wood, M. D., Rawe, M., Johansson, G., Pang, S., Soderquist, R., Patel, A., Nelson, S., Seibel, W., Ratner, N., and Sanchez, Y.  Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells.  Molecular Cancer Therapeutics. Jun 22. 2011. [Epub ahead of print]. PubMed ID: 21697395

Wood, M.D. and Sanchez, Y.  2010. Deregulated Ras signaling compromises DNA damage checkpoint recovery in S. cerevisiae. Cell Cycle. 2010 Aug 17. 9(16). [Epub ahead of print]. PubMed ID: 20716966

Pereira, E., Chen, Y. and Sanchez Y. Conserved ATRMec1 phosphorylation-independent activation of Chk1 by single amino acid substitution in the GD domain. Cell Cycle, 2009 Jun 1. 8(11): 1788-93. [Epub ahead of print]. PubMed ID: 19411848

Chen, Y., Caldwell, J.M., Pereira, E., Baker, R.W., and Sanchez, Y.  ATRMec1 phosphorylation-independent activation of Chk1 in vivo.  J. Biol. Chem., 2009. 284 (1), 182-190. PubMed ID: 18984588

Carrassa, L., Sanchez, Y., Erba, E., and Damia. G.  U20S Cells Lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint.  J Cell Mol Med. 2008. [Epub ahead of print]. PubMed ID: 19778378

Caldwell, J. M., Chen, Y., Schollaert, K. L., Theis, J. F., Babcock, G. F., Newlon, C. S., and Sanchez, Y. Orchestration of the S-phase and DNA-damage checkpoint pathways by replication forks from early origins. J. Cell Biol. 2008 Mar 24: 180(6): 1073-86. PubMed ID: 18347065

Schollaert, K. L., Poisson, J. M., Searle J. S, Schwanekamp, J. A., Tomlinson, C. R. and Sanchez, Y.  A novel role for Saccharomyces cerevisiae Chk1p in the response to replication blocks.  Mol. Biol. Cell. 2004. 15(9). PubMed ID: 15229282

Rogoff, H. A., Pickering, M. T., Frame F. M., Debatis, M. E. Sanchez, Y., Jones, S., and Kowalik T. F. Apoptosis Associated with Deregulated E2F Activity is Dependent on E2F1 and Chk2. Mol Cell Biol., 2004. 24(7): 2968-2977. PubMed ID: 15024084

Searle, J. S., Schollaert, K. L., Wilkins, B. and Sanchez, Y. The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression. Nat Cell Biol. 2004 Feb: 6(2): 138-45. Published online 2004 Jan 25. PubMed ID: 14743219

Goudelock, D. M, Jiang, K, Pereira, E., Russell, B. and Sanchez, Y.  Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-PK complex. J. Biol. Chem. 2003 Aug 8. 278: 29940-29947. Published online 2003 May 19. PubMed ID: 12756247

Jiang, K., Pereira, E., Maxfield, M., Russell, B., Goudelock, D. M. and Sanchez, Y.  Regulation of Chk1 includes chromatin association and nuclear retention following phosphorylation on Ser345. J. Biol. Chem. 2003. 278(27): 25207-25217. Published, JBC Papers in Press April 03. PubMed ID: 12676962

Kuznetzova, A. V., Meller, J., Schnell, P. O., Nash, J. A., Ignacal. M. L. , Sanchez, Y., Conaway, J. W., Conaway, R. C., and Czyzyk-Krzeska, M. F.  VHL tumor suppressor complex binds hyperphosphorylated large subunit of RNA Polymerase II through a proline hydroxylation motif and targets it for ubiquitination.  Proc. Natl. Acad. Sci. USA. 2003. 100:2606-2711. PubMed ID: 12604794

Bahassi E. M., Conn, C. W., Myer, D. L., Hennigan, R. F., McGowan, C. H., Sanchez, Y. and Stambrook, P. J. Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways. Oncogene. 2002. 21: 6633-6640. PubMed ID: 12242661

Damia, G. Sanchez, Y, Erba, E. and Broggini, M.  DNA damage induces p53-dependent downregulation of hChk1.  J. Biol. Chem. 2001. 276(14): 10641-10645. PubMed ID: 11152453

Conn, W. C., Hennigan, R. F, Dai, W., Sanchez, Y. and Stambrook, P. J.  Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3. Cancer Research. 2000. 60(24): 6826-6831. PubMed ID: 11156373

Sanchez, Y., Bachant, J., Wang, H., Liu, D., Fenghua Hu, Tezlaff, M and Elledge S. J.  Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms. Science. 1999. 286(5442): p. 1166-71. PubMed ID: 10550056

Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H. and Elledge, S. J.   Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA damage to Cdk regulation via Cdc25.  Science. 1997. 277: 1497-1501. PubMed ID: 9278511

Sanchez, Y., Zhou, Z., Huang, M., Kemp, B. E. and Elledge, S. J.  Analysis of Budding Yeast Kinases Controlled by DNA damage.  In Methods in Enzymology-Cell Cycle Control, 1997. vol 283. PubMed ID: 9251037

Navas, T. A., Sanchez, Y. and Elledge, S. J.  RAD9 and DNA polymerase E form parallel sensory branches for transducing the DNA damage checkpoint signal in S. cerevisiae.  Genes and Dev. 1996. 10: 2632-2643. PubMed ID: 8895664

Sanchez, Y., Lovell, M., Marin, M. C., Wong, P., Wolf, E., McDonnell, T. J. and Killary, A. M.  Tumor suppression and apoptosis of human prostate carcinoma mediated by a genetic locus within human chromosome 10pter-q11.  Proc. Natl. Acad. Sci. USA. 1996. 93: 2551-2556. PubMed ID: 8637912

Sanchez, Y. Desany, B., Jones, W. J., Liu, Q. Wang, B. and Elledge, S. J.  Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways.  Science. 1996. 271:357-360. PubMed ID: 8553072

Killary, A. M., Lott, S. T., and Sanchez, Y.  Functional Studies to Identify Tumor Suppressor Genes.  METHODS: A companion to Methods in Enzymology. 1995. v8: 234-246.

Sanchez, Y. and Elledge, S. J.  Stopped for Repairs. Bioessays, 17(6):545-548, 1995. PubMed ID: 7575496

Sanchez, Y., El-Naggar, A., Pathak, S. and Killary, A.M.  A tumor suppressor locus within human chromosome 3p14-3p12 mediates rapid cell death of renal cell carcinoma in vivo.  Proc. Natl. Acad. Sci. USA, 1994. 91:3383-3387. PubMed ID: 8159756

Sharp, Z.D., Helsel, S., Cao, Z., Barron, E.A., and Sanchez, Y.  DNA recognition element required for PUF-1 mediated cell-type-specific transcription of the rat prolactin gene.  Nucl. Acids, Res., 1989.17:2705-2722. PubMed ID: 2717408