CURRICULUM VITAE
(Short Form)
Roger Powell Smith

Address:

Department of Pharmacology and Toxicology
Dartmouth Medical School
7650 Remsen, Room #519
Hanover, NH 03755-3835
P: 603-650-1668; F: 603-650-1129
E-Mail: roger.p.smith@dartmouth.edu

Birth:

16 July 1932, Hokuchin, Korea (of American parents)

Education:

Ph.D., Pharmaceutical Chemistry, Purdue University, 1957
M.S., Pharmaceutical Chemistry, Purdue University, 1955
B.S., Pharmacy, Purdue University, 1953

Licensure:

Registered Pharmacist, State of New Hampshire, 1977-2000

Military Service:

1/Lt., Medical Service Corps, USAR, USAEUR Medical Laboratory, Landstuhl, Germany, 1957-60

Academic Appointments:

Irene Heinz Given Professor of Pharmacology and Toxicology, 1993-2000 (now Emeritus)
Adjunct Professor of Environmental Studies, Dartmouth College, 1984-2000
Adjunct Professor, Vermont Law School, S. Royalton, 1981-87
Chairman, Department of Pharmacology and Toxicology, 1976-87
Professor of Pharmacology and Toxicology, 1976-93
Acting Chairman, Department of Pharmacology and Toxicology, 1975-76
Professor of Toxicology, 1973-76
Associate Professor of Toxicology, 1968-73
Assistant Professor of Toxicology, 1963-68
Instructor in Toxicology, 1960-63

Hospital Appointments:

Associate Consulting Staff, Mary Hitchcock MemorialHospital, 1968-96
Consultant, VA Hospital Medical Center, White River Junction, VT, 1968-91

Awards and Honors:

Selected for Distinguished Professor Rounds in the Dartmouth Medical School 4th Year Course, Health, Society and the Physician, 2001.Faculty
Marshall, Dartmouth Medical School Class Day Ceremony, 10 June 2000.
Distinguished Fellow of the Albert J. Ryan Foundation, 1997

Dartmouth Medical School Chapter of Alpha Omega Alpha, 1991
Mary Hitchcock Memorial Hospital Service Club, Permanent Member, 1991 (25 years service)
Fellow of The Academy of Toxicological Sciences with Certification in Toxicology, 1989, Emeritus 1999
Distinguished Alumnus Award, Purdue University School of Pharmacy and Pharmacal Sciences, 1986
MA (h.c.), Dartmouth College, 1975
USPHS Career Development Awardee, 1966-71
Fellow of the American Association for the Advancement of Science, 1962

National and Regional Committees:

National Research Council, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee to Review the Toxicity of Nitrates and Nitrites in Drinking Water, 1994.
Chemical Substances Threshold Limit Value Committee, American Conference of Governmental Industrial Hygienists, Inc., 1991-92
Toxicology Information Program Committee, National Research Council, 1986- 88
Environmental Health Sciences Review Committee, NIEHS, NIH, 1985-87
Member of the Health Effects Institute Review Panel on Mechanisms of CO Toxicity, Albuquerque, 1984
Chairman, WHO Task Group on Environmental Criteria for Hydrogen Sulfide, Geneva, 1980.
Committee on Medical and Biological Effects of Environmental Pollutants, Division of Medical Sciences, National Research Council, and Chairman, Panel on Hydrogen Sulfide, 1975-77
United States Pharmacopeia Advisory Panel on Toxicology, 1974
Pharmacology-Toxicology Research Program Committee, NIGMS, 1972-76
Toxicology Study Section, NIH, 1969-72
ad hoc Advisory Group to the President on Nitrates, 1969

Editorial Boards:

inScight, 1998-2000
Toxicological Sciences, 1998-2000
Human and Experimental Toxicology, 1994-97.
Fundamental and Applied Toxicology, 1992-97.
Toxicology, 1990-96.
Journal of Pharmacology and Experimental Therapeutics, 1978-1999.
Associate Editor, Toxicology and Applied Pharmacology, 1972-78.
Toxicology and Applied Pharmacology, 1970-72.

ad hoc Reviewer:

Revierer, ATSDR draft document, Medical Management Guideline on Sulfur Dioxide, 2000
Revierer, ATSDR draft document, Medical Management Guideline on Hydrogen Cyanide, 2000
American Journal of Physiology: Heart and Circulatory PhysiologyToxicology and Applied Pharmacology
Handbook of Hazardous Materials
Canadian Journal of Physiology and Pharmacology
Applied Occupational and Environmental Hygiene
Critical Reviews in Toxicology
Annals of Internal Medicine (Ranked in top 30% of reviewers in '95 and '99; top 10% in 1996)
Human Pharmacology
Pharmacological Reviews
Biochemical Pharmacology
Journal of Toxicology, Clinical Toxicology
Jounal of Cardiovascular Pharmacology
Biochemical Journal
Journal of the Air and Waste Management Association
Environmental Health Perspectives
Molecular Pharmacology

Professional Societies:

Society of the Sigma Xi, Associate 1956, Full 1969, Emeritus 1997.
American Association for the Advancement of Science, 1960- (Fellow 1962; Emeritus 1997)
American Association of Poison Control Centers, 1963-85 (Treasurer 1964-68)
Society of Toxicology, 1966- (Education Committee, 1979-81)
American Society for Pharmacology and Experimental Therapeutics, 1967-2000
Society for Experimental Biology and Medicine, 1975-1989
American Conference of Governmental Industrial Hygienists, Inc., 1992-95

Bibliography:

Books:

Gleason, M. N., R. E. Gosselin, H. C. Hodge and R. P. Smith (1969). Clinical Toxicology of Commercial Products, 3rd ed., Williams and Wilkins, Baltimore.

Gosselin, R. E., H. C. Hodge, R. P. Smith and M. N. Gleason (1976). Clinical Toxicology of Commercial Products, 4th ed. Williams and Wilkins, Baltimore.

Hydrogen Sulfide, A Report by the Subcommittee on Hydrogen Sulfide (chaired by R. P. Smith) of the Committee on Medical and Biologic Effects of Environmental Pollutants, Assembly of Life Sciences, National Research Council, National Academy of Sciences, Washington, D. C., 1977. Reprinted by University Park Press, Baltimore, 1979.

Hydrogen Sulfide, Who Task Group on Environmental Health Criteria for Hydrogen Sulfide (chaired by R. P. Smith) World Health Organization, Environmental Health Criteria 19, Geneva, 1981.

Gosselin, R. E., R. P. Smith and H. C. Hodge (1984). Clinical Toxicology of Commercial Products, 5th ed., Williams and Wilkins, Baltimore.

Nierenberg, D. W. and R. P. Smith (1988). Clinical Problems in Basic Pharmacology. C. V. Mosby Co., St. Louis.

Smith, R. P. (1992). A Primer of Environmental Toxicology, Lea and Febiger, Malvern, PA. Nominated for the 1995 Rutstrum Author's Award of the Rutstrum Wilderness Trust.

Book Chapters:

Smith, R. P. (1959). Alkaloid biogenesis. In Modern Pharmacognosy (E. Ramstad, Ed.) McGraw-Hill, New York.

Gosselin, R. E., and R. P. Smith (1963). Ingredients index and Therapeutics index. In Clinical Toxicology of Commercial Products (M. N. Gleason, R. Gosselin and H. C. Hodge, Ed.) Williams and Wilkins, Baltimore.

Smith, R. P. (1969). The significance of methemoglobinemia in toxicology. In Essays in Toxicology, Vol. 1 (F. R. Blood, Ed.) Academic Press, New York.

Smith, R. P. (1975). Chapter 10. Toxicology of the formed elements of the blood. In Toxicology, The Basic Science of Poisons (L. J. Casarett and J. Doull, Ed.) Macmillan, New York.

Smith, R. P., and R. E. Gosselin (1976). Current concepts about the treatment of selected poisonings: Nitrite, cyanide, sulfide, barium and quinidine. Ann. Rev. Pharmacol. Toxicol. 16:189-199.

Smith, R. P. (1980). Chapter 14. Toxic responses of the blood. In Casarett and Doull's Toxicology, The Basic Science of Poisons, 2nd ed. (J. Doull, C. D. Klaassen and M. O. Amdur, Ed.) Macmillan, New York.

Smith, R. P. (1980). Mammalian toxicology and human health effects. In Ambient Water Quality Criteria for Cyanides. USEPA, Office of Water Regulation and Standards, Criteria and Standards Division, Washington, D. C. EPA 440/5-80-037, October.

Norton, J. M., and R. P. Smith (1981). Drugs affecting the oxygen transport function of hemoglobin. In Respiratory Pharmacology, Section 104, International Encyclopedia of Pharmacology and Therapeutics (J. Widdicombe, Section Ed.) Pergamon Press, Oxford.

Smith, R. P. (1985). Alleged neurotoxic effects of chronic cyanide exposure. In Neurotoxicology (K. Blum and L. Manzo, Ed.) Marcel Dekker, Inc., New York.

Smith, R. P. (1986). Chapter 8. Toxic responses of the blood. In Casarett and Doull's Toxicology, The Basic Science of Poisons, 3rd ed. (C. Klaassen, M. O. Amdur and J. Doull, Ed.) Macmillan, New York.

Smith, R. P. (1991). Chapter 8. Toxic responses of the blood. In Casarett and Doull's Toxicology: The Basic Science of Poisons, 4th ed. ( M. O. Amdur, J. Doull and C. D. Klaassen, Ed.) Macmillan, New York.

Plaa, G. L., and R. P. Smith. (1995). Chapter 104. General principles of toxicology. In Section XIII. Elements of Toxicology (G. L. Plaa and R. P. Smith, Ed.) of Human Pharmacology (P. L. Munson, Ed.) Chapman and Hall, New York pp. 1537-1543.

Smith, R. P. (1995). Chapter 112. Systemic antidotes. In Section XIII. Elements of Toxicology (G. L. Plaa and R. P. Smith, Ed.) of Human Pharmacology (P. L. Munson, Ed.) Chapman and Hall, New York, pp 1639-1640.

Smith, R. P. (1996). Chapter 11. Toxic responses of the blood. In Casarett and Doull's Toxicology: The Basic Science of Poisons, 5th ed. (C. D. Klaassen, Ed.) Macmillan, New York, pp. 335-354.

Rochelle, L. G., H. Kruszyna and R. P. Smith (1996). Chapter 1. Electron paramagnetic resonance detection of nitric oxide in biological samples. In Nitric Oxide Synthase, Characterization and Functional Analysis, (M. D. Maines, Ed) Academic Press, New York, pp. 3-13. [Methods in Neurosciences, Vol 31].

Symposia:

Smith, R. P., and H. Kruszyna (1976). Toxicology of some inorganic antihypertensive anions. Fed. Proc. 35:69-72. In Biochemical Aspects of Toxic Aents, (G. L. Plaa, Ed.) ASPET Fall Meeting, Université de Montréal, August 18-22, 1974.

Smith, R. P. Keynote speaker. (1990). Hydrogen sulfide: Overview, history, theories and unknowns. In Proceedings of International Conference on Hydrogen Sulphide Toxicity (M. G. Prior, S. H. Roth, F. H. Y. Green, W. C. Hulbert and R. Reiffenstein, Ed.) Banff, Alberta, Canada, June 18-21, 1989.

Sulfide Research Network, Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.

Smith, R. P., D. E. Wilcox, H. Kruszyna and R. Kruszyna (1990). Nitroprusside, a potpourri of biologically reactive intermediates. In Biological Reactive Intermediates IV: Molecular and Cellular Effects and Their Impact. on Human Health, (C. M. Witmer, R. R. Snyder, D. J. Jollow, G. F. Kalf, J. J. Kocsis, and I. G. Sipes, Ed.), Plenum Press, New York (Advances in Experimental Medicine and Biology , Volume 283).

Huot, A. E., E. Schiffeleers, H. Kruszyna, R. Kruszyna, R. P. Smith and M. P. Hacker (1991). Altered hemoglobin in erythrocytes exposed to nitric oxide secreting alveolar macrophages. In Biology of Nitric Oxide, Part II, Enzymology, Biochemistry and Immunology, (S. Moncada, M. A. Marletta, J. B. Hibbs, Jr. and E. A. Higgs, Ed.), Portland Press, Colchester UK, 1992, pp. 159-162.

Smith, R. P., L. R. Cantilena, S. Frasur, H. Kruszyna, R. Kruszyna, and D. E. Wilcox (1992). Nitric oxide hemoglobin (HbNO): Stability, detection in patients receiving nitroglycerin and lack of endogenous basal levels. In Biology of Nitric Oxide, Part I, Physiological and Clinical Aspects, (S. Moncada, M. A. Marletta, J. B. Hibbs, Jr. and E. A. Higgs, Ed.), Portland Press, Colchester UK, 1992, pp. 355-357.

Journal Articles:

Smith, R. P., G. E. Cwalina and E. Ramstad (l959). Studies on glutamic acid decarboxylase. J. Am. Pharm. Assoc., Sci. Ed. 48:103-105.

Smith, R. P. (1959). A poison control center in Europe. Med. Bull. U. S. Army, Europe 16:87-89.

Berninger, H., and R. Smith (1959). A modification of the spectrophotometric determination of carbon monoxide in blood enabling direct determination of per cent hemoglobin saturation. Clin. Chem. 5:127-134.

Leahy, T., and R. Smith (1960). Notes on methemoglobin determination. Clin. Chem. 6:148-152 and Erratum, Ibid. 7:148, 1961.

Smith, R. P. (1961). A poison information center for American armed forces in Europe. Mil. Med. 126:218-222.

Smith, R. P., and D. M. Smith (1961). Acute ipecac poisoning--report of a fatal case and review of the literature. N. Engl. J. Med. 265:523-525.

Smith, R. P. (1961). Trends in poison control. Health News 38:No. 9, 13-16.

Abbanat, R. A., and R. P. Smith (1964). The influence of methemoglobinemia on the lethality of some toxic anions. I. Azide. Toxicol. Appl. Pharmacol. 6:576-583.

Smith, R. P., and R. E. Gosselin (1964). The influence of methemoglobinemia on the lethality of some toxic anions. II. Sulfide. Toxicol. Appl. Pharmacol. 6:584-592.

Smith, R. P., and R. E. Gosselin (1966). On the mechanism of sulfide inactivation by methemoglobin. Toxicol. Appl. Pharmacol. 8:159-172.

Stolk, J. M., and R. P. Smith (1966). Species differences in methemoglobin reductase activity. Biochem. Pharmacol. 15:343-351.

Vaughan, M. C., R. P. Smith and R. E. Gosselin (1966). Effects of oxygen on determination of thiocholine by 5,5-dinitrobis(2-nitrobenzoic acid). Proc. Soc. Exp. Biol. Med. 122:50-55.

Gosselin, R. E., and R. P. Smith (1966). Trends in the therapy of acute poisonings. Clin. Pharmacol. Ther. 7:279-299. Reprinted in Australasian J. Pharm. Sci., Supple. 48:S2-S8 and S12-S18, 1967.

Smith, R. P., and R. A. Abbanat (1966). Protective effects of oxidized glutathione in acute sulfide poisoning. Toxicol. Appl. Pharmacol. 9:209-217.

Smith, R. P., A. A. Alkaitis and P. R. Shafer (1967). Chemically-induced methemoglobinemias in the mouse. Biochem. Pharmacol. 16:317-328.

Smith, R. P., R. E. Gosselin, J. A. Henderson and D. M. Anderson (1967). Comparison of the adsorptive properties of activated charcoal and Alaskan montmorillonite for some common poisons. Toxicol. Appl. Pharmacol. 10:95-104.

Smith, R. P. (1967). The nitrite-methemoglobin complex--its significance in methemoglobin analyses and its possible role in methemoglobinemia. Biochem. Pharmacol. 16:1655-1664.

Smith, R. P. (1967). The oxygen and sulfide binding characteristics of hemoglobins generated from methemoglobin by two erythrocytic systems. Mol. Pharmacol. 3:378-385.

Colton, T., R. E. Gosselin and R. P. Smith (1968). The tolerance of coffee drinkers to caffeine. Clin. Pharmacol. Ther. 9:31-39.

Klurfeld, G., and R. P. Smith (1968). Effects of chloride and bicarbonate on methemoglobin reduction in mouse erythrocytes. Biochem. Pharmacol. 17:1067-1077.

Smith, R. P., and W. R. Layne (1969). A comparison of the lethal effects of nitrite and hydroxylamine in the mouse. J. Pharmacol. Exp. Ther. 165:30-35.

Layne, W. R., and R. P. Smith (1969). Methylene blue and the reversal of chemically-induced methemoglobinemias in human erythrocytes. J. Pharmacol. Exp. Ther. 165:36-44

Smith, R. P. (1969). Cobalt salts: Effects in cyanide and sulfide poisoning and on methemoglobinemia. Toxicol. Appl. Pharmacol. 15:505-516.

Smith, R. P. (1970). Some features of the reaction between cobaltinitrite and hemoglobin. Toxicol. Appl. Pharmacol. 17:634-647.

Cranston, R. D., and R. P. Smith (1971). Some aspects of the reactions between hydroxylamine and hemoglobin derivatives. J. Pharmacol. Exp. Ther. 177:440-446.

Smith, R. P. (1971). Cobalt lysis and methemoglobin accumulation in human erythrocyte suspensions. Proc. Soc. Exp. Biol. Med. 136:701-706.

Smith, R. P. (1971). Spectrophotometric determination of methemoglobin and oxyhemoglobin in the presence of methylene blue. Clin. Toxicol. 4:273-285.

Bolyai, J. Z., R. P. Smith and C. T. Gray (1972). Ascorbic acid and chemically-induced methemoglobinemia. Toxicol. Appl. Pharmacol. 21:176-185.

Smith, R. P., and C. D. Thron (1972). Hemoglobin, methylene blue, oxygen interactions in human red cells. J. Pharmacol. Exp. Ther. 183:549-558.

Smith, R. P. (1973). Cyanate and thiocyanate: Acute toxicity. Proc. Soc. Exp. Biol. Med. 142:1041-1044.

Smith, R. P., and M. V. Olson (1973). Drug-induced methemoglobinemia. Semin. Hematol. 10:253-268. Reprinted (in Italian) in Aggiorn. Ematol. 12:103-125, 1975.

Felsenstein, W. C., R. P. Smith and R. E. Gosselin (1974). Toxicologic studies on the avicide, 3-chloro-p-toluidine. Toxicol. Appl. Pharmacol. 28:110-125.

Smith, R. P., and H. Kruszyna (1974). Nitroprusside produces cyanide poisoning via a reaction with hemoglobin. J. Pharmacol. Exp. Ther. 191:557-563.

Kruszyna, R., and R. P. Smith (1975). A method for discriminating between chemically induced changes in locomotor activity and whole body oxygen consumption in mice. Toxicol. Appl. Pharmacol. 31:390-402.

Borison, H. L., S. R. Snow, D. S. Longnecker and R. P. Smith (1975). 3-Chloro-p-toluidine: effects of lethal doses in rats and cats. Toxicol. Appl. Pharmacol. 31:403-412.

Kruszyna, H., R. Kruszyna and R. P. Smith (1975). Calibration of a turbidimetric method for sulfide. Anal. Biochem. 69:643-645.

Smith, R. P., R. Kruszyna and H. Kruszyna (1976). Management of acute sulfide poisoning, effects of oxygen, thiosulfate and nitrite. Arch. Environ. Health 31:166-169.

Norton, J. M., and R. P. Smith (1976). Drugs acting on hemoglobin and the oxygen transport system. Pharmacol. Ther. B 2:523-538.

Smith, L., H. Kruszyna and R. P. Smith (1977). The effect of methemoglobin on the inhibition of cytochrome c oxidase by cyanide, sulfide or azide. Biochem. Pharmacol. 26:2247-2250.

Kruszyna, R., R. P. Smith and L. C. Ou (1977). Method for measuring increased plasma hemoglobin in the presence of erythrocytes. Clin. Chem. 23:2156-2159.

Ou, L. C., and R. P. Smith (1978). Hemoglobinemia in rats exposed to high altitude. Exp. Hemat. 6:473-478.

Susman, J. L., J. F. Hornig, S. C. Thomae and R. P. Smith (1978). Pulmonary excretion of hydrogen sulfide, methanethiol, dimethyl sulfide and dimethyl disulfide in mice. Drug. Chem. Toxicol. 1:327-338.

Smith, R. P., R. Kruszyna and L. C. Ou (1979). Hemoglobinemia in rats exposed to high altitude is not due to an overload of catabolic mechanisms. Aviat. Space Environ. Med. 50:9-13.

Smith, R. P., and R. E. Gosselin (1979). Hydrogen sulfide poisoning. J. Occup. Med. 21:93-97.

Smith, R. P., R. Kruszyna and L. C. Ou (1979). Hemoglobinemia in mice exposed to high altitude. Pflugers Arch. 389:65-70.

Doherty, P. A., D. Van Riper, W. O. Berndt and R. P. Smith (1979). Failure of oxygen to influence the metabolism or distribution of cyanide or of thiosulfate in mice. Toxicol. Lett. 4:25-29.

Ou, L. C., D. Kim, W. M. Layton, Jr. and R. P. Smith (1980). Splenic erythropoiesis in polycythemic response of the rat to high altitude exposure. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 48:857-861.

Kruszyna, H., R. Kruszyna, J. Hurst and R. P. Smith (1980). Toxicology and pharmacology of some ruthenium compounds: Vascular smooth muscle relaxation by nitrosyl derivatives of ruthenium and iridium. J. Toxicol. Environ. Health 6:757-773.

Ou, L. C., and R. P. Smith (1981). Splenic origin of early-labeled bilirubin in rats exposed to high altitude. Proc. Soc. Exp. Biol. Med. 166:287-290.

Willhite, C. C., V. H. Ferm and R. P. Smith (1981). Teratogenic effects of aliphatic nitriles. Teratology 23:317-323.

Willhite, C. C., M. Marin-Padilla, V. H. Ferm and R. P. Smith (1981). Morphogenesis of axial skeletal (dysraphic) disorders induced by aliphatic nitriles. Teratology 23:325-333.

Willhite, C. C., and R. P. Smith (1981). The role of cyanide liberation in the acute toxicity of aliphatic nitriles. Toxicol. Appl. Pharmacol. 59:589-602.

Kruszyna, H., R. Kruszyna and R. P. Smith (1981). Detergent-catalyzed autoxidation of hemoglobin--species differences and implications for methemoglobin analyses. Arch. Toxicol. 49:43-48.

Kruszyna, R., H. Kruszyna and R. P. Smith (1982). Comparison of hydroxylamine, 4-dimethylaminophenol and nitrite protection against cyanide poisoning in mice. Arch. Toxicol. 49:191-202.

Doherty, P. A., V. H. Ferm and R. P. Smith (1982). Congenital malformations induced by infusion of sodium cyanide in the golden hamster. Toxicol. Appl. Pharmacol. 64:456-464.

Kruszyna, H., R. Kruszyna and R. P. Smith (1982). Nitroprusside increases cyclic guanylate monophosphate concentrations during relaxation of rabbit aortic strips and both effects are antagonized by cyanide. Anesthesiology 57:303-308.

Doherty, P. A., R. P. Smith and V. H. Ferm (1982). Tetramethyl substitution on succinonitrile confers pentylenetetrazole-like activity and blocks cyanide release in mice. J. Pharmacol. Exp. Ther. 223:635-641.

Doherty, P. A., R. P. Smith and V. H. Ferm (1983). Comparison of the teratogenic potential of two aliphatic nitriles in hamsters: succinonitrile and tetramethylsuccinonitrile. Fund. Appl. Pharmacol. 3:41-48.

Vitkun, S. A., R. P. Smith, E. E. French, W. H. Edwards and N. Watkins (1983). Heinz body hemolytic anemia in newborns and failure of laboratory studies to implicate a phenolic disinfectant. Pediatrics 71:352-358.

Horner, H. C., B. D. Roebuck, R. P. Smith and J. P. English (1983). Acute toxicity of some silver salts of sulfonamides in mice and the efficacy of penicillamine in silver poisoning. Drug Chem. Toxicol. 6:267-277.

Ou, L. C., and R. P. Smith (1983). Probable strain differences of rats in susceptibilities and cardiopulmonary responses to chronic hypoxia. Resp. Physiol. 53:367-377.

Schwerin, F. T., R. Rosenstein and R. P. Smith (1983). Cyanide prevents the inhibition of platelet aggregation by nitroprusside, hydroxylamine and azide. Thromb. Haemostas. 50:780-783.

Ou, L. C., and R. P. Smith (1984). Strain and sex differences in the cardiopulmonary adaptation of rats to high altitude. Proc. Soc. Exp. Biol. Med. 177:308-311.

Kruszyna, R., H. Kruszyna, P. A. Doherty and R. P. Smith (1984). Hypotensive effects of hydroxylamine in intact anesthetized dogs and cats. Arch. Toxicol. 55:203-205.

Kaplita, P. V., H. L. Borison, L. E. McCarthy and R. P. Smith (1984). Peripheral and central actions of sodium azide on circulatory and respiratory homeostasis in anesthetized cats. J. Pharmacol. Exp. Ther. 231:189-196.

Rutkowski, J. V., B. D. Roebuck and R. P. Smith (1985). Effects of protein-free diet and food deprivation on hepatic rhodanese activity, serum proteins and acute cyanide lethality in mice. J. Nutr. 115:132-137 and Erratum, Ibid. 115:415, 1985.

Williams, K. J., R. Rosenstein and R. P. Smith (1985). Substitution of tetramethylbenzidine for benzidine in cyanide analyses. Clin. Chim. Acta 145:113-118.

Kruszyna, H., R. Kruszyna and R. P. Smith (1985). Cyanide and sulfide interact with nitrogenous compounds to influence the relaxation of various smooth muscles. Proc. Soc. Exp. Biol. Med. 179:44-49.

Rutkowski, J. V., B. D. Roebuck and R. P. Smith (1986). Liver damage does not increase the sensitivity of mice to cyanide given acutely. Toxicology 38:305-314.

Kaplita, P. V., and R. P. Smith (1986). Pathways for the bioactivation of aliphatic nitriles to free cyanide in mice. Toxicol. Appl. Pharmacol. 84:533-540.

Rutkowski, J. V., B. D. Roebuck and R. P. Smith (1986). Allyl alcohol partially protects murine hepatic mitochondria against carbon tetrachloride. Toxicology 40:25-30.

Kruszyna, R., H. Kruszyna, R. P. Smith, C. D. Thron and D. E. Wilcox (1987). Nitrite conversion to nitric oxide in red cells and its stabilization as a nitrosylated valency hybrid of hemoglobin. J. Pharmacol. Exp. Ther. 241:307-313.

Jacobs, J. M., J. V. Rutkowski, B. D. Roebuck and R. P. Smith (1987). Rat hepatic mitochondria are more sensitive to allyl alcohol than are those of mice. Toxicol. Lett. 38:257-264.

Hill, N. C., L. C. Ou, C. D. Thron and R. P. Smith (1987). Time course of cardiopulmonary responses to high altitude in susceptible and resistant rat strains. Resp. Physiol. 70:241-249.

Kruszyna, H., R. Kruszyna, R. P. Smith and D. E. Wilcox (1987). Red blood cells generate nitric oxide from directly acting nitrogenous vasodilators. Toxicol. Appl. Pharmacol. 91:429-438.

Kruszyna, R., H. Kruszyna, R. P. Smith and D. E. Wilcox (1988). Generation ofvalency hybrids and nitrosylated species of hemoglobin in mice by nitric oxide vasodilators. Toxicol. Appl. Pharmacol. 94:458-465.

Devlin, D. J., J. W. Mills and R. P. Smith (1989). Histochemical localization of rhodanese activity in rat liver and skeletal muscle. Toxicol. Appl. Pharmacol. 97:247-255.

Devlin, D. J., R. P. Smith and C. D. Thron (1989). Cyanide metabolism in the isolated, perfused, bloodless hindlimbs or liver of the rat. Toxicol. Appl. Pharmacol. 98:338-349.

Shafer, P. R., D. E. Wilcox, H. Kruszyna, R. Kruszyna and R. P. Smith (1989). Decomposition and specific exchange of the trans-cyanide ligand on nitroprusside is facilitated by hemoglobin. Toxicol. Appl. Pharmacol. 99:1-10.

Devlin, D. J., R. P. Smith and C. D. Thron (1989). Cyanide release from nitroprusside in the isolated, perfused, bloodless liver and hindlimbs of the rat. Toxicol. Appl. Pharmacol. 99:354-356.

Smith, R. P., and C. C. Willhite (1990). Chlorine dioxide and hemodialysis. Reg. Toxicol. Pharmacol. 11:42-62.

Wilcox, D. E., H. Kruszyna, R. Kruszyna and R. P. Smith (1990). Effect of cyanide on the reaction of nitroprusside with hemoglobin: Relevance to cyanide interference with the biological activity of nitroprusside. Chem. Res. Toxicol. 3:71-76.

Sana, T. R., V. H. Ferm, R. P. Smith, R. Kruszyna, H. Kruszyna, and D. E. Wilcox (1990). Embryotoxic effects of sodium azide infusions in the Syrian hamster. Fund. Appl. Toxicol. 15:754-759.

Smith, R. P. (1991). Chemicals reacting with various forms of hemoglobin: Biological significance, mechanisms and determination. J. Forensic Sci. 31:662-672.

Smith, R. P., C. A. Louis, R. Kruszyna and H. Kruszyna (1991). Acute neurotoxicity of sodium azide and nitric oxide. Fund. Appl. Toxicol. 17:120-127.

Wang, Q., J. Jacobs, J. DeLeo, H. Kruszyna, R. Kruszyna, R. Smith and D. Wilcox (1991). Nitric oxide hemoglobin in mice and rats in endotoxic shock. Pharmacol. Lett. 49:PL55-PL60.

Huot, A. E., H. Kruszyna, R. Kruszyna, R. P. Smith and M. P. Hacker (1992). Formation of nitric oxide hemoglobin in erythrocytes co-cultured with alveolar macrophages taken from bleomycin treated rats. Biochem. Biophys. Res. Comm. 182:151-157.

Wheeler, M. G., A. A. Rozycki and R. P. Smith. (1992). Recreational propane inhalation in an adolescent male. J. Toxicol. - Clin. Toxicol. 30:135-139.

Ou, L. C., J. Chen, E. Fiore, J. C. Leiter, T. Brinck-Johnsen, G. F. Birchard, G. Clemons and R. P. Smith (1992). Ventilatory and hematopoietic responses to chronic hypoxia in two rat strains. J. Appl. Physiol. 72:2354-2364.

Cantilena, L. R., R. P. Smith, S. Frasur, H. Kruszyna, R. Kruszyna and D. E. Wilcox (1992). Nitric oxide hemoglobin in patients receiving nitroglycerin and failure to observe endogenous basal levels. J. Lab. Clin. Med. 120:902-907. Accompanied by an editorial: Marks, G. S. A sophisticated technique for measurement of nitric oxide: Implications for the mechanism of action of nitroglycerin, pp. 826-827.

Conrad, K. P., G. M. Joffe, H. Kruszyna, R. Krusxyna, L. G. Rochelle, R. P. Smith, J. E. Chavez and M. D. Mosher (1993). Identification of increased nitric oxide biosynthesis during pregnancy in rats. FASEB J. 7:566-571.

Kruszyna, H., R. Kruszyna, L. G. Rochelle, R. P. Smith and D. E. Wilcox (1993). Effects of temperature, oxygen, heme ligands and sulfhydryl alkylation on the reactions of nitroprusside and nitroglycerin with hemoglobin. Biochem. Pharmacol. 46:95-102.

Kruszyna, R., H. Kruszyna and R. P. Smith (1993). A spectrophotometric method for estimating methemoglobin concentration in the presence of cyanide. Am. J. Emerg. Med., 11:642-643.

Wang, Y., L. G. Rochelle, H. Kruszyna, R. Kruszyna, R. P. Smith and D. E. Wilcox (1994). An impurity in some samples of SIN-1 oxidizes it to nitric oxide in anaerobic solutions. Toxicology 88:165-176.

Ou, L. C., G. L. Sardella, J. C. Leiter, T. Brinck-Johnsen and R. P. Smith (1994). Role of sex hormones in development of chronic mountain sickness in rats. J. Appl. Physiol. 77:427-433.

Rochelle, L. G., H. Kruszyna, R. Kruszyna, A. Barchowsky, D. E. Wilcox and R. P. Smith (1994). Bioactivation of nitroprusside by porcine endothelial cells. Toxicol. Appl. Pharmacol. 128:123-128.

Smith, R. P., and D. E. Wilcox (1994). Toxicology of selected nitric oxide-donating xenobiotics with particular reference to azide. Crit. Rev. Toxicol. 24:355-377.

Wilcox, D. E., and R. P. Smith (1995). Detection and quantification of nitric oxide using electron magnetic resonance spectroscopy. Methods 7:59-70.

Rochelle, L. G., S. J. Morana, H. Kruszyna, M. A. Russell, D. E. Wilcox and R. P. Smith (1995). Interactions between hydroxocobalamin and NO: Evidence for a redox reaction between NO and reduced cobalamin and reversible NO binding to oxidized cobalamin. J. Pharmacol. Exp. Ther. 275:48-52.

Currie, J. L., L. A. Mott, S. C. Pennisi, B. D. Smith and R. P. Smith (1997). Potential for an external vaginal anti-itch cream containing benzocaine to cause methemoglobinemia in healthy females. Am. J. Obstet. Gynecol. 176:1006-1008.

Kruszyna, R., R. P. Smith and H. Kruszyna (1998). Determining sodium azide concentration in blood by ion chromatography. J. Forensic Sci. 43:192-194.

Kruszyna, H., J. S. Magyar, L. G. Rochelle, M. A. Russell, R. P. Smith and D. E. Wilcox (1998). Spectroscopic studies of nitric oxide interactions with cobalamin: Reaction of NO with superoxocobalamin(III) likely accounts for cobalamin reversal of the biological effects of NO. J. Pharmacol. Exp. Ther. 285:665-671.

Kam, H. Y., L. C. Ou, C. D. Thron, R. P. Smith and J. C. Leiter (1999). Role of the spleen in the exaggerated polycythemic response to hypoxia in chronic mountain sickness in rats.J. Appl. Physiol. 87:1901-1908.

Miscellaneous:

Smith, R. P. (1980). Profile of a department, Pharmacology and Toxicology. Dartmouth Medical School Alumni Magazine, Spring, 15-18 and 36.

Smith, R. P., and J. M. Barrington (1981). Unit 1. The biochemistry, pharmacology and toxicology of alcohols. In Alcohol Use and Its Medical Consequences (H. L. Bonkowsky, Ed.) Milner-Fenwick, Inc., Timonium, NJ.

Smith, R. P. (1991). Desperately seeking sulfide. Dartmouth Med. 15:No. 4, 34-37.

Smith, R. P. (1991) Cyanide poisoning. Audio Digest, Emergency Med. 8:No. 21, Nov. 4.

Smith, R. P., and J. M. Barrington (1994). Unit 1. The biochemistry, pharmacology and toxicology of alcohols, 2nd ed. In Alcohol Use and Its Medical Consequences (H. L. Bonkowsky, Ed.) Milner-Fenwick, Inc., Timonium, NJ.

Smith, R. P. (1995). Nonsteroidal anti-inflammatory drugs (NSAID) that release nitric oxide (NO). InflammoPharmacology 3:195-196 (Invited editorial)

Smith, R. P. (1997). Editorial commentary—Sulfide poisoning. J. Toxicol. Clin. Toxicol. 35:305-306 (Invited editorial)

Smith, R. P. (2000). <http://www.dartmouth.edu/~rpsmith/index.html>

Smith, R. P. (2000). What makes my baby blue? Dartmouth Medicine 24:No. 4, pp. 26-31 and 51.

Smith, R. P. (2001). Blue in the face. J. Am. Acad. Dermatol. 44:872. (Letter)

Smith, R. P. (2002). The Desktop Guide to Complementary and Alternative Medicine: An Evidence-Based Approach. Ann. Intern. Med. 136:176. (Book review)

<http://www.dartmouth.edu/~toxmetal/TXSHas.htm>

Rev. 2/11/04