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Pharmacology and Toxicology

COURSES IN PHARMACOLOGY AND TOXICOLOGY

122. Neuropharmacology

10F: Arrange Offered in alternate years

The course will provide both didactic lectures and small group journal club sessions. It will focus on pharmacological mechanisms of drugs that effect the nervous system with teaching expertise from Neurology, Psychiatry, Anesthesiology and Pharmacology. Open to all graduate students and upper level undergraduates (with permission from the Course Directors). Course Directors: J. DeLeo, A. Green.

123. Graduate Toxicology

12W: Arrange Offered in alternate years

This course pro-vides an introduction to toxicology as a discipline, with a focus on the molecular basis for toxicity of chemicals in biological systems. Major topics include: principles of cell and molecular toxicology, xenobiotic metabolism, molecular targets of cellular toxicity, genetic toxicology, chemical carcinogenesis, immunotoxicology, neurotoxicology, clinical toxi-cology, and quantitative risk assessment.

Faculty lectures and discussion. This course is open to graduate, medical and advanced undergraduate students (with permission from the Course Director). Course Director: C. Tomlinson.

124. Ethical Conduct of Research

10F: Arrange Offered every year

This course is required for all PEMM and MCB graduate students. There will be approximately four one-and a half hour small group discussion sessions and four one hour lectures with the times to be arranged. Topics will include: mentoring, data collection, academic integrity, ethical use of human subjects and laboratory animals, authorship, sponsored research and intellectual property.

Faculty lectures and discussion. Course Directors: J. DeLeo, B. North.

126. Cancer Biology

11S: Arrange Offered in alternate years

The course will present a comprehensive survey of the biology, biochemistry, pharmacology, and genetics of cancer. Students will become familiar with such areas as cancer terminology, epidemiology, carcinogenesis, tumor promotion, metastasis, oncogenes, tumor suppressor genes, tumor viruses, growth factors, hormones, immunology, and therapy. Where possible, emphasis will be placed on the most recent cell and molecular aspects of cancer. The class will be in lecture format and meet for 3 hours each week.

Faculty lectures and discussion. Prerequisite: PEMM 101 and 102, or permission of instructor. Course Director: A. R. Eastman.

131. Current Approaches in Experimental Therapeutics

12S: Arrange Offered in alternate years

The course will present a survey of current methods and approaches in pharmacologic, molecular and experimental therapeutic research. Topics will include pharmacogenomics, pharmacokinetics, functional genomics, in vivo imaging, global gene expression, proteomics, gene targeting, gene therapy and drug screening and delivery. The class will be in lecture format with student discussion and participation. The class will meet for 3 hours each week.

Faculty lectures and discussion. Prerequisite: per-mission of instructor. Course Directors: M. Spinella and J. DiRenzo.

137. Project Research (Qualifying Examination)

All terms: Arrange

141. Research Rotation 1

All terms: Arrange

142. Research Rotation 2

All terms: Arrange

143. Research Rotation 3

All terms: Arrange

216/217. Medical Pharmacology

DMSII calendar (terms 1-5) Offered every year

The major, conceptual modules are general principles, pharmacology of autonomic and central nervous system, cardiovascular pharmacology, endocrine and autacoid pharmacology, chemotherapy, and toxicology. Instruction is primarily through classroom lectures (67 hours) with four small group sessions on clinical pharmacology in Terms I and II. Emphasis is placed on understanding the dynamic mechanisms by which drugs modify normal bio-chemical or physiological functions and how they correct pathophysiological disturbances of those functions.

Faculty lectures and small group facilitators. Prerequisite: DMSI. Course Director: N. Shworak.

297. Level I: part-time research: 1 course equivalent

All terms: Arrange

298. Level II: part-time research: 2 course equivalent

All terms: Arrange

299. Level III: full-time thesis research: 3 course equivalent

All terms: Arrange