|
Chair: Ethan Dmitrovsky
Primary appointee faculty: Professors M. Cole, R. W. Craig, E.
Dmitrovsky, A. R. Eastman, J. W. Hamilton, B. D. Roebuck, R. P. Smith, M. B.
Sporn; Associate Professors J. Hwa, D. J. Robbins, Y. Sanchez, M. Spinella;
Assistant Professors J. DiRenzo, A. F. Kisselev; Research Associate Professor
H. C. Yohe; Research Assistant Professor S. J. Freemantle
REQUIREMENTS FOR THE DOCTOR'S DEGREE (PH.D)
To qualify for award of the Ph.D. degree, a student must fulfill the
following requirements:
1. Satisfactory completion of the following required courses:
Biochemistry 101 or equivalent
Biochemistry 103 or equivalent
Pharmacology 124. Ethical Conduct of Research
Pharmacology 127. Pathophysiology for
Pharmacology
Pharmacology 129. Principles of Receptor Action
Pharmacology 130. Graduate Pharmacology
Three Elective Courses
2. Attendance and participation in the Department's weekly seminars and
journal clubs.
3. Students must be enrolled in a research course every term; rotations in
the early terms and thesis research credit thereafter.
Pharmacology 141, 142, 143. Research Rotations (three to be completed within
9 months)
Pharmacology 297, 298, 299. Thesis Research in Pharmacology, a credit/no
credit course for graduate students
4. Pharmacology 137. Grant Writing in Pharmacology and Toxicology.
(Satisfactory completion of a written and oral qualifying examination)
5. Satisfactory completion of a significant research project, and
preparation of a thesis describing this research.
6. Successful defense of the thesis in an oral examination, and presentation
of the work in a seminar.
For further information, see the Graduate Study Bulletin.
COURSES IN PHARMACOLOGY AND TOXICOLOGY
122. Neuropharmacology
07F: Arrange Offered in alternate years
The course will provide both didactic lectures and small group journal club
sessions. It will focus on pharmacological mechanisms of drugs that effect the
nervous system with teaching expertise from Neurology, Psychiatry,
Anesthesiology and Pharmacology. Open to all graduate students and upper level
undergraduates (with permission from the course directors). Course Directors:
J. DeLeo, A. Green.
123. Graduate Toxicology
07S: Arrange Offered in alternate years
This course is open to graduate, medical and advanced undergraduate
students. It provides an introduction to toxicology as a discipline, with a
focus on the molecular basis for toxicity of chemicals in biological systems.
Major topics include: principles of cell and molecular toxicology, xenobiotic
metabolism, molecular targets of cellular toxicity, genetic toxicology,
chemical carcinogenesis, immunotoxicology, neurotoxicology, clinical
toxicology, and quantitative risk assessment.
Faculty lectures and discussion. Prerequisite: Undergraduate or graduate
biochemistry, or permission of instructor. Instructors: Hamilton (course
director) and others.
124. Ethical Conduct of Research (Identical to Physiology
124)
06F: Arrange Offered every year
This course is required for all graduate students supported by NIH training
grants within the institution, but all other graduate students are strongly
encouraged to attend. There will be approximately seven one-hour
lecture/discussion sessions with the times to be arranged. Topics will include:
scientific freedom, ethical treatment of data, ethical use of laboratory
animals, priority of discovery, fraud and deception, and science and the
political process.
Faculty lectures and discussion. Instructors: North, Lomax, Green, Brown,
Hoopes, Kavanagh, and others.
126. Cancer Biology
07S: Arrange Offered in alternate years
This course will present a comprehensive survey of the biology,
biochemistry, pharmacology, and genetics of cancer. Students will become
familiar with such areas as cancer terminology, epidemiology, carcinogenesis,
tumor promotion, metastasis, oncogenes, tumor suppressor genes, tumor viruses,
growth factors, hormones, immunology, and therapy. Where possible, emphasis
will be placed on the most recent cell and molecular aspects of cancer. The
class will be in lecture format and meet for 3 hours each week.
Faculty lectures and discussion. Prerequisite: Graduate biochemistry, or
permission of instructor. Instructors: Eastman (course director) and
others.
127. Pathophysiology for Pharmacology
07X: Arrange Offered every year
This course will provide the necessary physiology and pathology background
required to understand the mechanisms of action and indications for commonly
used drugs in cardiology, nephrology, respiratory medicine, neurology,
psychiatry, gastroenterology and endocrinology. The class will consist of 10 x
3 hour sessions where student presentations will be followed by a case study,
highlighting how various drugs affect organ systems. This course is required
for graduate students prior to taking Pharmacology 130 (Graduate
Pharmacology).
Prerequisite: permission of instructor. Hwa (course director).
129. Principles of Receptor Action
08W: Arrange Offered in alternate years
The principles of ligand reactions with the receptors and the resulting
changes in cellular signaling will be discussed in lecture format. Topics will
include the cellular and molecular basis for pharmacologic selectivity, for
receptor theory and kinetics, for specific receptor actions. Emphasis will be
placed on recent developments in receptor biology and signaling cascades and on
the methodologies required to study these processes. The course will meet 4
hours per week and course materials will include current literature reviews and
research articles.
Faculty lectures and discussion. Prerequisite: permission of the instructor.
Instructors: Cole and Robbins (course directors) and others.
130. Graduate Pharmacology
06F: Arrange Offered every year
Graduate students will participate in the key elements of the Medical
Pharmacology course for the year II DMS students. The major, conceptual modules
for the graduate students are general principles, pharmacology of autonomic and
central nervous system, cardiovascular pharmacology, chemotherapy, and
toxicology. Separate essay based, integrative exams will be offered.
Instruction is primarily through classroom lectures (42 hours in the fall term
with an additional 10 hours in the winter and spring terms) with three small
group sessions on clinical pharmacology in the fall term. Emphasis is placed on
understanding the dynamic mechanisms by which drugs modify normal biochemical
or physiological functions and how they correct pathophysiological disturbances
of those functions.
Faculty lectures and small group facilitators. Prerequisite: permission of
the instructor. Instructor: Hwa (course director) and others.
131. Current Approaches in Experimental Therapeutics
07S: Arrange Offered in alternate years
This course will present a survey of current methods and approaches in
pharmacologic, molecular and experimental therapeutic research. Topics will
include pharmacogenomics, pharmacokinetics, functional genomics, in
vivo imaging, global gene expression, proteomics, gene targeting, gene
therapy and drug screening and delivery. The class will be in lecture format
with student discussion and participation. The class will meet for 3 hours each
week.
Faculty lectures and discussion. Prerequisite: permission of instructor.
Instructors: Spinella and DiRenzo (course directors) and others.
137. Project Research (Qualifying Examination)
All terms: Arrange
141. Research Rotation 1
All terms: Arrange
142. Research Rotation 2
All terms: Arrange
143. Research Rotation 3
All terms: Arrange
216/217. Medical Pharmacology
DMSII calendar (terms 1-5) Offered every year
The major, conceptual modules are general principles, pharmacology of
autonomic and central nervous system, cardiovascular pharmacology, endocrine
and autacoid pharmacology, chemotherapy, and toxicology. Instruction is
primarily through classroom lectures (67 hours) with three small group sessions
on clinical pharmacology in Terms I and II. Emphasis is placed on understanding
the dynamic mechanisms by which drugs modify normal biochemical or
physiological functions and how they correct pathophysiological disturbances of
those functions.
Faculty lectures and small group facilitators. Prerequisite: permission of
instructor. Instructors: Hwa (course director) and others.
297. Level I: part-time research: 1 course equivalent
All terms: Arrange
298. Level II: part-time research: 2 course equivalent
All terms: Arrange
299. Level III: full-time thesis research: 3 course equivalent
All terms: Arrange
|
