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Chair: William R. Green
B. L. Berwin (Microbiology and Immunology), D. J. Bzik (Microbiology and
Immunology), A. Cheung (Microbiology and Immunology), J. R. Conejo-Garcia
(Norris Cotton Cancer Center, and Microbiology and Immunology), M. W. Fanger
(Microbiology and Immunology), S. N. Fiering (Microbiology and Immunology, and
Genetics), J. D. Gorham (Pathology, and Microbiology and Immunology), W. R.
Green (Microbiology and Immunology), W. F. Hickey (Pathology, and Microbiology
and Immunology), D. A. Hogan (Microbiology and Immunology), L. H. Kasper
(Medicine, and Microbiology and Immunology), R. J. Noelle (Microbiology and
Immunology), G. A. O'Toole (Microbiology and Immunology), W. R. Rigby
(Medicine, and Microbiology and Immunology), C. L. Sentman, (Microbiology and
Immunology), P. R. Sundstrom (Microbiology and Immunology), R. K. Taylor
(Microbiology and Immunology), M. J. Turk (Norris Cotton Cancer Center, and
Microbiology and Immunology), E. J. Usherwood (Microbiology and Immunology), W.
F. Wade (Microbiology and Immunology).
The Ph.D. in Microbiology and Immunology is administered by the Microbiology
and Immunology Department of Dartmouth Medical School. To qualify for award of
the Ph.D. degree in Microbiology and Immunology (M/I), a student must fulfill
the following requirements:
1. Satisfactory completion of an intensive three-term
course in cell and molecular biology and biochemistry - Biochemistry 101,
Genetics 102, Biochemistry 103, a one-term teaching assignment, and a
three-term course in laboratory experience in Microbiology and Immunology,
including cell and molecular biology. The last will consist of three small
research projects, conducted in rotation with different faculty members for
periods of approximately three months.
2. Satisfactory completion of three other graduate
level courses from the approved list of course offerings.
3. Attendance at, and participation in, the weekly
seminar series and journal club of the Program.
4. Participation in the weekly Research in Progress
(RIP) series.
5. Satisfactory completion of an oral qualifying
examination.
6. Satisfactory completion of a significant research
project, and preparation of a thesis describing this research.
7. Successful defense of the thesis in an oral
examination, and presentation of the work in a Seminar.
The courses listed below are primarily designed for graduate students. The
student should decide, in consultation with his/her committee and course
instructors, whether his/her background is appropriate for the content of the
course.
142. Advanced Cellular and Molecular Immunology
06F: Arrange Offered in alternate years
Advanced immunology including contemporary topics of humoral and
cell-mediated immune responses. Development and differentiation, lymphoid
sub-populations, cell cooperation, cytokines, immunogenetics and major
histocompatibility restriction, antigen receptor systems, antigen processing
pathways, clinical aspects, including the interactions of retroviruses,
particularly the AIDS (HIV) virus, with the immune system, and the use of
immunologic systems to study gene regulation, receptor-ligand interactions, and
other fundamental molecular processes.
Lectures and discussion. Prerequisite: Biochemistry 102 or an equivalent, or
permission of the instructor. Noelle and associates.
145. Human Genetics (Identical to Genetics 145)
07S: Arrange Offered in alternate
years
This course will consider the structure, organization and function of the
human genome, with an emphasis on how human genetics will develop now that the
genome of humans and many other organisms have been sequenced. The mouse and
other model organisms will also be discussed in regard to how they may
genetically differ or be similar to humans. The course will have two sessions a
week (110 minute sessions). Each session will cover a specific topic and for
most sessions the topic will be presented by one of the students enrolled in
the course.
Prerequisite: Permission of the instructor. Fiering.
146. Immunotherapy
08S: Arrange Offered in alternate years
This course will consider both basic scientific and therapeutic aspects of
three important areas of immunology: vaccination, tumor immunology, and
autoimmunity. The vaccination module will consider current vaccination
strategies and new advances in vaccinology. The tumor immunology module will
consider the challenges of tumor antigen identification and mechanism of
delivery to the immune system to combat malignancies. Autoimmunity will be
discussed to describe basic mechanisms behind the disease and what can be done
to modulate the immune response to prevent or treat such diseases. Sessions
will consist of a faculty-lead discussion of the primary literature relating to
each topic, interspersed with student lead presentations on selected areas.
Prerequisite: A previous immunology course and/or permission of an
instructor. Usherwood and associates.
148. Advanced Molecular Pathogenesis
07F: Arrange Offered in alternate years
An advanced course in molecular pathogenesis with emphasis on genetic
aspects of host-microbe interactions and modern model genetic systems for the
study of important human pathogens. Each session will begin with a 50- to
80-minute lecture pertaining to the topic area and will be followed by a 1.5-
to 2-hour discussion of current papers (assigned reading) pertaining to the
topic area. Discussion of the assigned reading for a particular session centers
around a set of questions developed by the student presenter in collaboration
with the instructor and based upon a short written report that the student has
prepared on the topic.
Prerequisite: permission of the instructor. Bzik, Cheung, and
associates.
149. Emerging Model Systems in Microbiology: Using Molecular and Genetic
Approaches to Study Complex Systems
07S: Arrange Offered in alternate years
This course uses the discussion of emerging model systems to illustrate
important concepts in microbiology. The format will combine lectures and the
discussion of primary literature/review articles-similar to the format of the
Molecular Pathogenesis course (M/I 148). An important goal of the course is to
introduce graduate students to potential topics for post-doctoral research and
to some of the faculty that work in these areas. Each course period will focus
on an individual topic in some depth. Students will present a one-hour lecture
followed by leading a one-hour discussion of papers related to the topic of the
day. Students will be expected to present papers in one class (which have been
selected and compiled), and discuss these papers in the context of material
covered in the lecture portion of the class. Guests will include 2-3 people
from the Microbiology and Immunology Seminar Series who work on model systems
discussed in the class. The schedule of the course will be arranged such that
the papers are discussed the week before the visiting speaker's seminar. The
students will meet with the speaker immediately after the seminar for an
informal discussion and reception. Attending this discussion/reception will be
required for the students in the class, but open to any students that want to
attend.
Prerequisite: permission of the instructor. O'Toole.
167. Molecular Pathogenesis of Fungi and Parasites (Identical to
Biology 67)
07W, 08W: 2A
Lectures and discussion about the biology, ecology, genetics, biochemistry
and pathology of eukaryotic pathogens which are important causes of infectious
diseases. Biochemical similarities between mammalian host cells and eukaryotic
pathogens limit options for therapeutic strategies, challenge drug discovery
efforts and heighten the impact of drug resistant organisms. The course
emphasizes fungi which are major pathogens in AIDS and other immunosuppressed
patients and will touch on parasites such as malaria which devastate human
populations world-wide.
Prerequisite: Biology 45 (Molecular Biology) and Biology 46 (Microbiology)
or equivalent Biology 40 (Biochemistry I) and Biology 42 (Immunology) are
recommended. Sundstrom.
169. Supervised Teaching in Microbiology and Immunology
All terms: Arrange
This course is required for all graduate students, based on the assertion
that an essential element of graduate education is the experience gained in
teaching other students. Such teaching experience is of particular relevance to
students interested in academic careers. Students will conduct laboratory or
discussion sessions in undergraduate courses under the supervision of the
course faculty. The faculty and student teaching assistant work very closely to
develop lab and discussion assignments. In some cases, the students are
encouraged to present lectures for which they receive detailed feedback on
their teaching style. In all cases students will receive instruction on
effective teaching techniques through weekly preparation sessions. Topics for
discussion include how to teach the material, how to run a discussion, how to
evaluate student responses, and grading. Performance will be monitored
throughout the term and appropriate evaluation, coupled with detailed
suggestions for improvement, will be provided. This course is not open to
undergraduates. Prerequisite: At least one year of graduate study. Staff of the
Program.
197. Graduate Research I: Level I
All terms: Arrange
An original individual experimental or theoretical investigation beyond the
undergraduate level in Microbiology and Immunology. This course is open only to
graduate students, prior to passing their qualifying exam; it may be
elected for credit more than once. This course carries one course
credit and should be elected by students conducting research and also electing
two or more other graduate or undergraduate courses. Staff of the Program.
198. Graduate Research I: Level II
All terms: Arrange
An original individual experimental or theoretical investigation beyond the
undergraduate level in Microbiology and Immunology. This course is open only to
graduate students, prior to passing their qualifying exam; it may be
elected for credit more than once. This course carries two course
credits and should be elected by students electing only departmental colloquia
in addition to research. Staff of the Program.
199. Graduate Research I: Level III
All terms: Arrange
An original individual experimental or theoretical investigation beyond the
undergraduate level in Microbiology and immunology. This course is open only to
graduate students, prior to passing their qualifying exam; it may be
elected for credit more than once. This course carries three course
credits and should be elected by students conducting research exclusively in
any one term. Staff of the Program.
264, 265, 271. Graduate Research Colloquium in Microbiology and
Immunology
F, W, S: Arrange
All students must take a journal club/RIP course during each term of
residence, except summer. An essential element of scientific training is in the
critical analysis and communication of experimental research in an oral format.
Evaluation will be based on quality of the work described, quality of critical
analysis, and on presentation style, including effective use of audio-visual
materials. All students will be required to participate in at least one Journal
Club/Research in Progress series. Although minor variations in format exist
among the several series, all students will make oral presentations that
describe work from the current literature. Normally these series meet every
other week for two hours. This course is not open to undergraduates.
M/I 264. Immunology
M/I 265. Molecular Pathogenesis
M/I 271. Chromatin Structure
297. Graduate Research II: Level I
All terms: Arrange
An original individual experimental or theoretical investigation beyond the
undergraduate level in Microbiology and immunology. This course is open only to
graduate students, subsequent to passing their qualifying exam; it may
be elected for credit more than once. This course carries one course
credit and should be elected by students conducting research and also electing
two or more other graduate or undergraduate courses. Mentor from the
Program.
298. Graduate Research II: Level II
All terms: Arrange
An original individual experimental or theoretical investigation beyond the
undergraduate level in Microbiology and Immunology. This course is open only to
graduate students, subsequent to passing their qualifying exam; it may
be elected for credit more than once. This course carries two course
credits and should be elected by students electing only departmental colloquia
in addition to research. Mentor from the Program.
299. Graduate Research II: Level III
All terms: Arrange
An original individual experimental or theoretical investigation beyond the
undergraduate level in Microbiology and Immunology. This course is open only to
graduate students, subsequent to passing their qualifying exam; it may
be elected for credit more than once. This course carries three course
credits and should be elected by students conducting research exclusively in
any one term. Mentor from the Program.
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