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XXChair: John S. Winn
Professors J. J. BelBruno, R. S. Cantor, R. Ditchfield, D. S. Glueck, G.
W. Gribble, R. P. Hughes, P. A. Jacobi, J. E. G. Lipson, D. E. Wilcox, J. S.
Winn; Assistant Professors R. B. Grubbs, F. J. Kull; Senior Lecturers S. P.
Milde, P. S. Veale; Adjunct Professors J. W. Hamilton, R. A. Naumann, R. M.
Ross, H. M. Swartz; Adjunct Associate Professors T. U. Gerngross, U. J. Gibson,
D. R. Madden; Adjunct Assistant Professor B. C. Bostick; Research Professors C.
L. Braun, D. M. Lemal, T. A. Spencer; Research Associate Professor T.
Honda.
REQUIREMENTS FOR THE CHEMISTRY MAJOR
The Chemistry Department offers four major programs. All major programs
require an average GPA of 2.0 in all courses counted toward the major,
including prerequisites taken in Chemistry. All courses that would serve as
prerequisites to or count toward a major in Chemistry and that are presented at
the time the student submits a major card must individually have a GPA of 2.0
or higher. Three of the major programs are offered as majors in chemistry:
Plan A, for those who wish a broad and thorough training in chemistry;
Plan B, for those whose scientific interests are only partially based
in chemistry; and a modified major, which is similar to Plan B, but
also includes a second program involving another college department.
Plan A should be chosen by students who plan to do graduate work in
chemistry or a closely allied science. Such students should normally add
further courses in chemistry, physics, and mathematics to the plan's minimum
requirements. Plan A is also a suitable choice for premedical students.
Plan B is less structured and is suitable for students planning to
engage in chemically-related careers, such as medicine, environmental science,
life science, or industrial science, or professions for which the study of
chemistry may prove desirable, such as teaching, law, or business.
The fourth program offered by the Chemistry Department is a major in
biophysical chemistry. This is a relatively structured major designed for
students interested in biological chemistry and chemical methods for studying
life processes. It provides a strong background for graduate work in
biophysical chemistry, structural biology, biochemistry, and biomedical
science, and is suitable for premedical students. Students are encouraged to
add further courses in chemistry, biochemistry, biological sciences,
mathematics, and physics to the plan's minimum requirements.
Dartmouth College requires that all majors must complete a substantial,
graded culminating or integrating activity in their major. Many chemistry
majors will satisfy this requirement by participating in undergraduate research
by registering for one or more terms of Chemistry 87, Undergraduate
Investigation in Chemistry. Often such students will be enrolled in the
Chemistry Honors Program as well.
Other chemistry majors will satisfy the requirement for a culminating or
integrating experience by including in their major programs one of the
three-course groups listed below. The course groups, each of which provides an
integrated presentation of an important area of modern chemical sciences, are:
Biophysical Chemistry Chemistry 61, 62, and 67; Physical
Chemistry Chemistry 71, 72, and 73; Chemical Applications, Synthesis
and Characterization Chemistry 63, 64, and one additional course from
among Chemistry 90, 91, 92, and 93.
Students must indicate their plans for satisfying the requirement for the
culminating or integrating experience by the time they enroll in the major and
submit their major cards. They must confirm their plans at the beginning of the
fall term of the senior year. Modified majors with Chemistry as the primary
department must define a culminating or integrating experience as part of the
coherent and unified whole of their modified major with written approval of the
Department's Undergraduate Advisory Committee.
The computation of the average in the major will be based upon all courses
that are eligible to be counted toward the major.
1. PLAN A MAJOR
Prerequisite: Chemistry 5-6 (or 3-6 or 10); Mathematics 3, 8, and 13 (or
equivalents); and Physics 13-14 (strongly recommended) or 3-4 or
15-16.
Required Courses: Chemistry 51 or 57, 52 or 58, 64, 71, 72, and 73.
Two additional courses selected from among Chemistry 41, 63, 67, 87, 90, 91,
92, and 93; graduate-level courses in Chemistry; Physics 19; Biology 40;
Mathematics 20, 22 or 24, 23, and 46; and, with prior written
permission, relevant major credit (or graduate-level) courses in other
departments in the Division of the Sciences. Chemistry 41 cannot be taken in
conjunction with Biology 40.
2. PLAN B MAJOR
Prerequisite: Chemistry 5-6 (or 3-6 or 10); Mathematics 3 and 8 (or
equivalent); and Physics 13-14 (strongly recommended) or 3-4 or
15-16.
Required Courses: Of the eight courses, a minimum of six must be in
chemistry to include a) Chemistry 51 or 57, 61 and 62 or 71 and 72,
and 64; b) two additional courses from the following group: Chemistry 41, 52 or
58, 63, 67, 73, 87, 90, 91, 92, 93, and graduate-level courses in chemistry.
Note that Chemistry 72 is a prerequisite to Chemistry 73.
The remaining two courses may be additional chemistry courses from group b)
above or may be chosen from the following: Physics 19; Biology 40; Mathematics
20, 22 or 24, 23 and 46; and, with prior written permission, relevant
major credit (or graduate-level) courses in other departments in the Division
of the Sciences. Chemistry 41 cannot be taken in conjunction with Biology
40.
3. MODIFIED MAJOR
Modified Major with Chemistry as the primary department
Prerequisite: As required by courses elected.
Required Courses: Six in total, which must include Chemistry 51 or 57, 64,
and 61 or 71. The other two courses must be Chemistry Department courses.
Chemistry 41 cannot be taken in conjunction with Biology 40.
Four additional courses from the secondary department selected with the
approval of any member of the Undergraduate Advisory Committee (and under
certain circumstances by the secondary department; see the Regulations under
Department Major).
Modified Major with Chemistry as the secondary department
Prerequisite: As required by courses elected.
Required Courses: Four courses, which must be chemistry offerings, suitable
(beyond prerequisites to the major) for completion of the Plan A or Plan B
major.
4. BIOPHYSICAL CHEMISTRY MAJOR
Prerequisite: Chemistry 5-6 (or 3-6 or 10); Mathematics 3 and 8 (or
equivalent); Physics 13-14 (strongly recommended) or 3-4 or 15-16.
(Biology 12 and 13 are recommended but not required.)
Required Courses: Chemistry 41, 51 or 57, 52 or 58, 61, 62, 64, and 67.
One additional course selected from among Chemistry 63, 87, 90, 91, 92, or
93; graduate-level courses in chemistry; Engineering Sciences 35; Mathematics
20, 22 or 24, 23, or 46; Physics 19; and with prior written
permission, relevant major credit (or graduate-level) courses in other
departments in the Division of the Sciences. Chemistry 71, 72 and 73 may be
substituted for Chemistry 61, 62 and the one additional course.
Students considering a Chemistry Department major are strongly encouraged to
take Chemistry 5-6 (or 10 or 3-6) in their first year. Students with advanced
placement in English, foreign language, or chemistry are urged to consider
taking Physics 13-14 during the first year. This is also advisable for those
students who delay completion of the language requirement until sophomore year
in Language Study Abroad. Students who plan to participate in Language Study
Abroad should give early attention to the need for careful curriculum planning.
In some cases it may be advisable to postpone the LSA term to the fall term of
the junior year. If so, it is necessary to obtain (routine) approval from the
Registrar for deferral of completion of the Language requirement.
All Chemistry Department majors have required courses that are to be taken
in the junior winter and spring terms. For example, Plan A majors take
Chemistry 64 and 71 in the junior winter term followed by Chemistry 72 in their
junior spring, while Biophysical Chemistry majors take Chemistry 64 in their
junior winter followed by Chemistry 61 in the junior spring term. Plan B majors
who elect Chemistry 71 and 72 must take these courses in their junior year. The
timing of these courses has important ramifications for the completion of
prerequisite courses. As a general guideline, it is recommended that the
physics and mathematics prerequisites for these courses, as well as Chemistry
51 or 57, be completed by the end of the sophomore spring term. Specifically,
Plan A majors must complete Physics 13 (or 15, or 3 and 4) and
Mathematics 13 before they take Chemistry 71, and Plan B and Biophysical
Chemistry majors must complete Physics 13 (or 15, or 3 and 4) and
Mathematics 8 before they take Chemistry 61. Any changes of courses from
those listed on the major card filed with the Department must be approved in
writing by a departmental adviser before the course is taken for
credit.
Many Chemistry Department majors do research projects. This research is
usually done during the senior (and sometimes junior) year and often for credit
(see Chemistry 87), though occasionally a stipend is available to allow a
student to do full-time research during a leave term. All majors are urged to
investigate the numerous possible research projects offered by chemistry
faculty members. A brochure describing faculty research interests and the
Chemistry 87 application form are available from the Department staff (102
Burke). The brochure enables a student to identify research areas of particular
interest. A final choice of research project is made after consultation with
the faculty member(s) concerned. The completed application form is submitted to
the Chair for signature.
Certification as a public school Chemistry teacher is available through
partnership with the Education Department. Contact the Education Department for
details about course requirements.
REQUIREMENTS FOR THE CHEMISTRY MINOR
The Chemistry Department offers a single minor program. Any student wishing
to enroll in the minor program must submit a minor card signed by a member of
the Undergraduate Advisory Committee no later than the day before final
examinations begin in fall term of senior year.
Prerequisite: Chemistry 5-6 (or 3-6 or 10) and Mathematics 3
Required Courses: Chemistry 51 or 57 and 64
Two additional courses selected from among Chemistry 41, 52 or 58, 61, 62,
63, 71, 72, 87, 90, 91, 92, and 93; or graduate-level courses in chemistry. The
NRO option is disallowed for courses taken to fulfill the chemistry minor.
Chemistry 61 and 62 cannot be taken in conjunction with Chemistry 71 and
Chemistry 72. Chemistry 41 cannot be taken in conjunction with Biology 40.
Students should note that many of the courses listed above have prerequisites
in addition to Chemistry 6 and Mathematics 3.
REQUIREMENTS FOR THE MATERIALS SCIENCE MINOR
The minor in Materials Science is sponsored by faculty in Chemistry, Physics
and Engineering with an interest in interdisciplinary education and research in
materials science (see section on Materials Science).
CHEMISTRY DEPARTMENT HONORS PROGRAM
A student whose grades meet the minimum College requirement for honors work
(see Honors Major under Regulations) may apply to be admitted to the Honors
Program. An honors major follows the basic pattern outlined in the requirements
for the chemistry major but is very strongly urged to elect additional courses
in chemistry and allied sciences.
An honors student carries out one of two individual projects. Usually an
original experimental or theoretical investigation is undertaken in a
well-defined area of interest under the guidance and supervision of a member of
the faculty. A student with a strong interest in teaching may, however,
formulate and carry out under the direction of a member of the faculty a
program combining the development of instructional materials with actual
experience in classroom or laboratory teaching. In either case, on completion
of the work the student will write a thesis and take an oral examination.
A student electing an original experimental or theoretical investigation may
conduct it by electing Chemistry 87 three times (counting as three courses
toward graduation, but only once toward the minimum group of major courses) or
during a leave term of full-time effort. He or she may also request
consideration of any appropriate combination of Chemistry 87 and noncredit
research. A project concerned with the development of educational materials and
experience in teaching will be similar in extent.
Ordinarily, the Honors Program will be undertaken by seniors, but juniors
who have progressed sufficiently far in satisfying the normal requirements may
be permitted to participate. A student who wishes to participate in the Honors
Program must apply for admission to the Program by submitting a form, available
from the Department staff, before beginning work on an honors project,
unless special permission has been obtained from the Chair. Before or at the
time of application the student must arrange for the supervision of the work,
normally by a member of the faculty of the Department. The deadline for
applications is the third day of the winter term of the senior year.
Additional information is available from the Department office.
Those students who satisfactorily complete the Honors Program with a 'B+'
average or better in the grade(s) assigned to their honors work at the time of
examination will earn Honors recognition in the major or, in appropriate cases,
High Honors. High Honors will be granted only by vote of the Department on the
basis of outstanding independent work and outstanding performance in the major.
An interim evaluation of honors students will be made after one term and
continuation will be recommended for those students whose work demonstrates the
capacity for satisfactory (B+) work. Students who satisfactorily complete the
Honors Program will have Honors in Chemistry or Biophysical Chemistry, or, when
appropriate, High Honors in Chemistry or Biophysical Chemistry, entered on
their permanent record.
REQUIREMENTS FOR THE MASTER'S DEGREE (M.S.)
The general requirements for the Master's degree are given in the Graduate
Studies section under Regulations. These requirements, together with the
specific requirements of the Department of Chemistry normally allow completion
of the degree in two years.
The specific requirements are as follows:
1. Each student must pass with a grade of P or better eight courses from the
offerings in chemistry and allied areas that have been chosen in consultation
with the adviser and approved by the Graduate Student Advisory Committee
(GSAC). Chemistry 256 and one term of Chemistry 257 may count. Up to four
courses may be in graduate-level research, but they may not include the
Colloquium courses 140 or 141, nor may courses numbered below 100 count in the
eight-course total.
2. The student must complete a satisfactory thesis and pass creditably an
oral examination upon this thesis.
3. In the course of this training, the student must gain experience in
teaching, including completion of Chemistry 256.
REQUIREMENTS FOR THE DOCTOR'S DEGREE (PH.D.) IN CHEMISTRY
A student will be admitted to candidacy for the doctorate after satisfying
the following requirements:
1. Completion, by the start of the Fall term of the student's second year in
the program, through an appropriate combination of Dartmouth courses or
performance on diagnostic entrance examinations, of a breadth requirement in
three of the four topical areas of biological, inorganic, organic, and physical
chemistry.
2. Passing within a specified time a total of five cumulative examinations
in chemistry at an advanced level, at least three of which must be from an area
closely allied with the student's research area.
3. Presentation before the Department of a lecture unrelated to the thesis
topic.
4. Submission and oral defense of an original research proposal in an area
removed from the student's own thesis research.
The candidate will receive the doctorate upon:
1. Satisfactory completion of an original thesis project of high quality and
substantial significance, and approval of the thesis embodying the results of
this research.
2. Successful defense of this thesis in an oral examination.
A candidate for the doctorate will take various courses in chemistry and
allied fields that are pertinent to their area of study. He or she will also
participate actively in undergraduate teaching, including completion of
Chemistry 256. It is anticipated that a graduate student will normally complete
all of the requirements for the doctorate in approximately five years. It is
not necessary to earn a master's degree as a prerequisite to the doctorate.
More complete information can be obtained from the brochure, Graduate
Study in Chemistry at Dartmouth, obtainable from the Department of
Chemistry.
REQUIREMENTS FOR THE DOCTOR'S DEGREE (PH.D.) IN CHEMISTRY-MATERIALS
A student will be admitted to candidacy for the doctorate after satisfying
the following requirements:
1. Completion, by the start of the Fall term of the student's second year in
the program, through an appropriate combination of Dartmouth courses or
performance on diagnostic entrance examinations, of a breadth requirement in
three of the four topical areas of biological, inorganic, organic, and physical
chemistry.
2. Successful completion, by the end of the student's third year in the
program, of four core courses satisfying the breadth requirement in Materials
Chemistry, and a minimum of three elective courses selected from the
Chemistry-Materials elective course list.
3. Annual presentation of a Research in Progress lecture to the Materials
Chemistry Group, and submission of an annual research progress report to the
student's Research Advisory Committee.
4. Submission and oral defense of an original research proposal in an area
removed from the student's own thesis research.
The candidate will receive the doctorate upon:
1. Satisfactory completion of an original thesis project of high quality and
substantial significance, and approval of the thesis embodying the results of
this research.
2. Successful defense of this thesis in an oral examination.
A candidate for the doctorate will take additional courses in chemistry and
allied fields as required for their area of study. He or she will also
participate actively in undergraduate teaching, including completion of
Chemistry 256. Students are required to attend research discussion meetings of
the Center for Nanomaterials Research at Dartmouth, as well as seminars
designated as Materials Seminars by the Center. It is anticipated that a
graduate student will normally complete all of the requirements for the
doctorate in approximately five years. It is not necessary to earn a master's
degree as a prerequisite to the doctorate.
3.
General Chemistry
07W, 08W: 10; Laboratory: Arrange
An introduction to the fundamental principles of chemistry, including
chemical stoichiometry; the properties of gases, liquids, and solids;
solutions; chemical equilibria; and an introduction to thermodynamics.
Chemistry 3 is intended for students whose preparation in science and
mathematics may be inadequate for Chemistry 5. The course moves at a more
moderate pace and emphasizes those topics which are essential as preparation
for further work in chemistry and for medical school. The laboratory work
emphasizes physical-chemical measurements, quantitative analysis, and
synthesis.
Students enroll initially in Chemistry 5, and enrollment in Chemistry 3 is
then by invitation only based on secondary school background, CEEB
scores, and performance in mathematics during the fall term. Students who
successfully complete both Chemistry 3 and Mathematics 2 or 3 will be eligible
to enroll in Chemistry 6.
Prerequisite: Mathematics 1 or 3. Students who have taken Mathematics 1 as a
prerequisite for Chemistry 3 must take Mathematics 2 concurrently with
Chemistry 3. Supplemental course fee required. Dist: SLA.
5-6. General Chemistry
5. 06F: 10 07W: 9L, 10 07F: 10 08W: 9L, 10;
Laboratory: Arrange
6. 07S, 08S: 9L, 10; Laboratory: Arrange
An introduction to the fundamental principles of chemistry, including
chemical stoichiometry; the properties of gases, liquids, and solids;
solutions; chemical equilibria; atomic and molecular structure; an introduction
to thermodynamics; reaction kinetics; and a discussion of the chemical
properties of selected elements. The laboratory work emphasizes
physical-chemical measurements, quantitative analysis, and synthesis.
An outline of topics for review of secondary school background in
preparation for college general chemistry is available from the Department of
Chemistry.
Students who are eligible to receive advanced placement credit for Chemistry
5-6 may not enroll in Chemistry 5-6 or Chemistry 10 for credit without
permission of the Department. Advanced placement credit for Chemistry 5-6 will
be withdrawn for students who subsequently enroll in Chemistry 5-6 or Chemistry
10.
Prerequisite: Mathematics 3 (or Mathematics 1 and 2). Students who wish to
take Mathematics 2 concurrently with Chemistry 5 must consult with a Chemistry
5 instructor. Chemistry 5, or Chemistry 3, and Mathematics 2 or 3 are
prerequisites for Chemistry 6. Supplemental course fee required. Dist:
SLA.
7. First-Year Seminars in Chemistry
Consult special listings
10. Honors First-Year General Chemistry
06F, 07F: 10; Laboratory W or Th 2:00-6:00 p.m.
Chemistry 10 is a general chemistry course for students with a strong
background in chemistry and mathematics who may have an interest in majoring in
the sciences. The course will cover selected general chemistry topics important
for higher level chemistry courses. These include thermodynamics, reaction
kinetics, quantum mechanics, and bonding. Laboratory work will emphasize
physico-chemical measurements and quantitative analysis.
Chemistry 10 is open only to first-year students and enrollment is
limited. Admission is by satisfactory performance on a general chemistry
proficiency test given during Orientation. Adequate mathematics preparation,
equivalent to Mathematics 3, is also required. Chemistry 10 is offered in the
fall term and is the prerequisite equivalent to Chemistry 5/6. Students who
successfully complete Chemistry 10 will also be granted credit for Chemistry 5,
if they have not already been granted such credit.
Prerequisite: Satisfactory performance on the general chemistry proficiency
test and credit for Mathematics 3 or equivalent. Supplemental course fee
required. Dist: SLA.
41. Biological Chemistry
07S, 08S: 12; Laboratory M, W or Th 2:00-6:00 p.m.
This course is a one-term introduction to biochemistry presented from a
chemical perspective. This course is intended for chemistry majors and will be
divided into three sections, using specific examples to demonstrate and stress
the role and integration of organic, inorganic and physical chemistry as
applied to biochemical processes. Laboratories cover chemical methods applied
to biological chemistry problems.
Prerequisite: Chemistry 52, or permission of the instructor. Students with credit for Biology 77 or 78
are not eligible to receive credit for Chemistry 41. Supplemental course fee
required. Dist: SLA.
51-52. Organic Chemistry
51. 06F, 07S, 07F, 08S: 11; Laboratory Tu,W or Th
2:00-8:00 p.m.
52. 07W, 07X, 08W: 11; Laboratory Tu,W or Th
2:00-8:00 p.m.
A two-term introduction to the chemistry of carbon compounds. The lectures
deal with the preparation, properties, and reactions of most of the important
classes of organic compounds. There is considerable stress upon reaction
mechanisms and some attention is given to naturally occurring substances of
biological importance.
The laboratory work will introduce the student to experimental techniques
and instrumental methods including several types of chromatography and
spectroscopy, organic synthesis, and the systematic identification of organic
compounds.
Prerequisite: Chemistry 6 (or 10), or permission of the instructor.
Supplemental course fee required. Dist: SLA.
57-58. Organic Chemistry
57. 06F, 07F: 11; Laboratory: M 2:00-8:00 p.m.
58. 07W, 08W: 11; Laboratory: M 2:00-8:00 p.m.
A two-term introduction to the chemistry of carbon compounds intended
primarily for students planning a chemistry major or career of research in a
chemically-related science (including medical science). The laboratory work is
similar to, but slightly more research-oriented than, the laboratory work in
Chemistry 51-52. It introduces the student to experimental techniques and
instrumental methods (including chromatographic techniques and NMR, IR and UV
spectroscopy) through application to synthesis, identification of organic
compounds, and individual projects. Enrollment in Chemistry 57-58 is
limited.
Prerequisite: Chemistry 6 (or 10), and permission of instructor.
Supplemental course fee required. Dist: SLA.
61. Basic Physical Chemistry I
07S, 08S: 11; Laboratory M or Th 2:00-6:00
An examination of the laws of classical thermodynamics, followed by
applications to the properties of gases, liquids, and solids, as well as to
solutions, phase, and chemical equilibria. Kinetic theory of gases at
equilibrium. Laboratories cover physical chemistry techniques drawn from these
areas. Students will normally elect either the Chemistry 61-62 sequence or the
Chemistry 71-72 sequence. Chemistry 61 may not be selected in conjunction with
either Chemistry 71 or Chemistry 72.
Prerequisite: Chemistry 6 (or 10) and Physics 13 (or 15, or Physics 3
and 4) and Mathematics 8, or permission of the instructor.
Supplemental course fee required. Dist: SLA.
62. Basic Physical Chemistry II
06F, 07F: 12; Laboratory M or Tu 2:00-6:00
Topics in chemical reaction kinetics and the application of quantum
mechanics to chemical bonding and spectroscopy. Laboratories cover physical
chemistry techniques drawn from these areas. Students will normally elect
either the Chemistry 61-62 sequence or the Chemistry 71-72 sequence. Chemistry
62 may not be selected in conjunction with either Chemistry 71 or Chemistry
72.
Prerequisite: Chemistry 61 and Chemistry 64, or permission of the
instructor. Supplemental course fee required. Dist: SLA.
63. Environmental Chemistry
07X: 9L; Laboratory Th 2:00-6:00
A study of the chemistry of current environmental problems and potential
solutions. The course will deal with such topics as atmospheric chemistry,
chemicals and cancer, and the chemistry of resource management. A few
laboratory experiments emphasizing modern methods of instrumental analysis for
substances in the environment will be included in the course.
Prerequisite: Chemistry 51 or 57, or permission of the instructor.
Supplemental course fee required. Dist: TLA.
64. Basic Inorganic Chemistry
07W, 08W: 9L; Laboratory W or Th 2:00-6:00
A study of bonding, structure, physical and chemical properties, and
chemical reactions of inorganic compounds. Examples will be drawn from main
group and transition metal compounds.
The laboratory will involve preparations of inorganic compounds which
illustrate appropriate experimental techniques for syntheses and manipulations,
and methods for characterization of inorganic compounds using instrumental
methods.
Prerequisite: Chemistry 51 or 57, or permission of the instructor.
Supplemental course fee required. Dist: SLA.
67. Physical Biochemistry
07W, 08W: 11; Laboratory W 2:00-6:00
Chemistry 67 covers the structural and chemical properties of proteins and
nucleic acids, including ligand binding, enzymatic catalysis, the structural
basis and functional significance of protein-nucleic acid recognition, and
protein folding. The course also covers the application of physical and
spectroscopic techniques, including X-ray crystallography, nuclear magnetic
resonance, microscopy, fluorescence and circular dichroism, to the study of
biological macromolecules. The laboratory introduces these experimental methods
in the study of proteins.
Prerequisite: Chemistry 41, Chemistry 62 or 72, and Chemistry 52 or 58, or
permission of the instructor. Supplemental course fee required. Dist:
SLA.
71. Macroscopic Physical Chemistry
07W, 08W: 11; Laboratory M or Th 2:00-6:00
An examination of the fundamental laws of classical thermodynamics is
followed by applications to the properties of gases, liquids, and solids, as
well as to solutions, phase and chemical equilibria, surface phenomena and
electrochemistry. The accompanying laboratory work in this course and that in
Chemistry 72 and 73 is largely instrumental.
Prerequisite: Chemistry 6 (or 10), Mathematics 13, and Physics 13 (or 15, or
Physics 3 and 4), or permission of the instructor. Supplemental course
fee required. Dist: SLA.
72. Microscopic Physical Chemistry I
07S, 08S: 11; Laboratory M or Th 2:00-6:00
An examination of the fundamental ideas of quantum mechanics and their
application to simple model systems such as the linear harmonic oscillator and
a confined particle, and to atomic and molecular structure. Application of
quantum theory to electronic, vibrational, rotational, and magnetic resonance
spectroscopies.
Prerequisite: Chemistry 64 and Chemistry 71, or permission of the
instructor. Supplemental course fee required. Dist: SLA.
73. Microscopic Physical Chemistry II
06F, 07F: 11; Laboratory W or Th 2:00-6:00
Chemical kinetics: experimental and theoretical aspects of the study of the
rates and mechanisms of chemical reactions. Photophysical and photochemical
kinetics. Kinetic theory of gases. Transport phenomena. Introduction to
statistical mechanics and chemical reaction dynamics.
Prerequisite: Chemistry 72, or permission of the instructor. Supplemental
course fee required. Dist: SLA.
87. Undergraduate Investigation in Chemistry
All terms: Arrange
An original and individual investigation with associated literature study in
one of the fields of chemistry under the supervision of a member of the staff.
Students electing the course will carry out preliminary reading during the
preceding term and normally participate in a weekly colloquium. Open to
qualified majors and minors, normally seniors, with permission of the Chair.
The course may be elected more than once, but may be counted only once in
satisfying the minimum major requirements. It may be elected for the last
term in residence only if elected previously, or if the student has been doing
research outside of this course.
Students electing the course write a report and take an oral examination at
the end of the term in which they last elect the course.
Prerequisite: sufficient training in the area of chemistry to be
investigated, and permission of the Chair. Chair and Staff of the
Department.
90. Advanced Inorganic Chemistry: Organometallic Chemistry (Identical
to Chemistry 130)
07S: 10 Offered in alternate years
A study of the structure, bonding, and chemical properties of organometallic
compounds of the main group and transition elements. Applications to organic
synthesis and homogeneous catalysis will be discussed, and organometallic
compounds of the lanthanide and actinide elements may also be discussed.
Prerequisite: Chemistry 64, or permission of the instructor. Dist:
SCI. Hughes.
91. Inorganic Chemistry: Catalysis (Identical to Chemistry
131)
07F: 10 Offered in alternate years
The role of metals in homogeneous and heterogeneous catalysis, with an
emphasis on mechanisms of catalytic reactions. Applications to industrial
processes, organic synthesis, and asymmetric synthesis will be discussed.
Prerequisite: Chemistry 90, or permission of the instructor. Dist:
SCI.
92. Inorganic Biochemistry (Identical to Chemistry 132 and Biochemistry
132)
08S: 10 Offered in alternate years
The role of metal ions in biological systems. Topics include metal ion
transport, storage, and interaction with proteins and nucleic acids;
metalloproteins involved in oxygen transport and electron transfer;
metalloenzymes involved in activation of oxygen and other substrates; and
medicinal, toxicity, and carcinogenicity aspects of metals; as well as
inorganic model chemistry of bioinorganic systems. Several physical methods are
introduced, and their application to current research on the above topics is
considered.
Prerequisite: Chemistry 64, and Chemistry 41 or Biology 77, or permission of
the instructor. Dist: SCI.
93. Physical Organic Chemistry (Identical to Chemistry 151)
06F: 9L Offered in alternate years or as needed
Modern theories of organic reaction mechanisms, particularly the use of
physical-chemical principles to predict the effect of changing reaction
variables, especially reactant structures, on reactivity. The structure,
stability, and reactivity of carbanions and carbocations, as well as SN1 and
SN2 reactions, are discussed.
Prerequisite: Chemistry 52 or 58, or permission of the instructor. Dist:
SCI.
102. Quantum Chemistry
Offered as needed
An introduction to the quantum mechanics of molecular systems. Approximate
methods for calculating the electronic structure of molecules are discussed.
Particular emphasis is placed on molecular orbital methods at the empirical,
semi-empirical, and ab-initio levels. Evaluation of such methods for studies of
molecular geometry, conformational problems, thermochemical data, and
spectroscopic parameters is presented. Other topics considered include the
electronic structure of hydrogen bonded systems and of excited states. Methods
which include the effects of electron correlation are briefly outlined.
Prerequisite: Chemistry 72 or equivalent, or permission of the
instructor.
104. Chemical Thermodynamics
Offered as needed
The laws of thermodynamics and their application to problems of equilibrium
in various homogeneous and heterogeneous systems of chemical interest. Brief
introduction to chemical aspects of non-equilibrium thermodynamics.
Prerequisite: Chemistry 71 or equivalent, or permission of the
instructor.
105. Statistical Thermodynamics
Offered as needed
Elements of equilibrium statistical thermodynamics for classical and quantum
mechanical systems, with applications to ideal gases, crystalline solids,
imperfect gases and liquids.
Prerequisite: Chemistry 73 or equivalent, or permission of the
instructor.
106. Molecular Structure and Spectra
Offered as needed
A study of optical spectroscopy including selected topics from amongst point
group theory, vibrational spectra of polyatomic molecules, electronic and
vibronic spectra of molecules and rotational spectra. May be offered on
tutorial basis.
Prerequisite: Chemistry 72 or equivalent, or permission of the
instructor.
107. Chemical Kinetics
Offered as needed
Kinetics of chemical reactions in various media; reaction rate expressions,
mechanisms, elementary processes. Elementary theories of rate processes;
activated complex theory, elementary collision theory, unimolecular
decomposition. Such topics as diffusion control of reactions, catalysis, and
photochemistry will be treated as time allows.
Prerequisite: Chemistry 72 or equivalent, or permission of the
instructor.
108. Chemistry of Macromolecules: Physical Properties and
Characterization
Offered as needed
An introduction to the physical chemistry of macromolecules. Light
scattering and other characterization techniques; thermodynamic and transport
properties of macromolecular solutions. Structure-property correlations in
amorphous and crystalline polymers.
Prerequisite: Chemistry 71, or Chemistry 61 and permission of the
instructor.
109. Chemistry of Macromolecules: Synthesis and Characterization
07S: Arrange
An introduction to the chemistry of organic polymers. The basic classes of
polymerization will be discussed, with attention to kinetic and mechanistic
details. Special emphasis will be placed upon living polymerization techniques
and their application toward architectural control. Additional content will
include, as time permits, topics of current interest such as: polymers in
organic synthesis, polymeric assemblies and biomimetic/bioconjugate polymers.
For selected topics, key articles from the chemical literature will be
discussed.
Prerequisite: Chemistry 52 or 58, or permission of the instructor.
Grubbs.
122. Topics in Advanced Physical Chemistry
Offered as needed
Treatment at an advanced level of one or more areas of physical chemistry.
The subject matter varies from year to year; accordingly, the course may be
taken for credit more than once.
Offered on a tutorial basis to qualified students.
123. Graduate Toxicology (Identical to Pharmacology and Toxicology
123)
07S: Arrange Offered in alternate years
This course is open to graduate, medical and advanced undergraduate
students. It provides an introduction to toxicology as a discipline, with a
focus on the molecular basis for toxicity of chemicals in biological systems.
Major topics include: principles of cell and molecular toxicology, xenobiotic
metabolism, molecular targets of cellular toxicity, genetic toxicology,
chemical carcinogenesis, immunotoxicology, neurotoxicology, clinical
toxicology, and quantitative risk assessment.
Faculty lectures and discussion. Prerequisite: Undergraduate or graduate
biochemistry, or permission of instructor.
124. Analytical Chemistry and Inorganic Instrumental Analysis
(Identical to Earth Sciences 124)
07F: Arrange Offered in alternate years
This course is directed towards graduate students planning to use inorganic
chemical analysis in their thesis work. The lectures and seminars focus on the
theory and application of modern instrumental analysis and analytical
chemistry. The theoretical backgrounds for a number of inorganic instrumental
analytical methods are given, and examples of their application to problems of
interest for analytical chemists working in the fields of earth science,
chemistry, biology and environmental science are presented. The lectures cover
ion chromatography, electrochemistry, atomic absorption, inductively coupled
plasma optical emission and inductively coupled plasma mass spectrometry. The
theory and concepts of analytical chemistry are provided along with statistical
tools, uncertainty calculations and data treatment methods useful in analytical
chemistry.
Prerequisites: Chemistry 5 and Chemistry 6 or permission of instructor.
130. Advanced Inorganic Chemistry: Organometallic Chemistry (Identical
to Chemistry 90)
07S: 10 Offered in alternate years
A study of the structure, bonding, and chemical properties of organometallic
compounds of the main group and transition elements. Applications to organic
synthesis and homogeneous catalysis will be discussed, and organometallic
compounds of the lanthanide and actinide elements may also be discussed.
Prerequisite: Chemistry 64, or permission of the instructor. Hughes.
131. Advanced Inorganic Chemistry: Catalysis (Identical to Chemistry
91)
07F: 10 Offered in alternate years
The role of metals in homogeneous and heterogeneous catalysis, with an
emphasis on mechanisms of catalytic reactions. Applications to industrial
processes, organic synthesis, and asymmetric synthesis will be discussed.
Prerequisite: Chemistry 90, or permission of the instructor.
132. Inorganic Biochemistry (Identical to Chemistry 92 and Biochemistry
132)
08S: 10 Offered in alternate years
The role of metal ions in biological systems. Topics include metal ion
transport, storage, and interaction with proteins and nucleic acids;
metalloproteins involved in oxygen transport and electron transfer;
metalloenzymes involved in activation of oxygen and other substrates; and
medicinal, toxicity, and carcinogenicity aspects of metals; as well as
inorganic model chemistry of bioinorganic systems. Several physical methods are
introduced, and their application to current research on the above topics is
considered.
Prerequisite: Chemistry 64, and Chemistry 41 or Biology 77, or permission of
the instructor.
137. Methods of Materials Characterization (Identical to Physics 128
and Engineering Sciences 137)
07S: 2A Offered in alternate years
This survey course discusses both the physical principles and practical
applications of the more common modern methods of materials characterization.
It covers techniques of both microstructural analysis (OM, SEM, TEM, electron
diffraction, XRD), and microchemical characterization (EDS, XPS, AES, SIMS,
NMR, RBS and Raman spectroscopy), together with various scanning probe
microscopy techniques (AFM, STM, EFM and MFM). Emphasis is placed on both the
information that can be obtained together with the limitations of each
technique. The course has a substantial laboratory component, including a
project involving written and oral reports, and requires a term paper.
Prerequisite: Engineering Sciences 24, or permission of the instructor.
140. Chemistry Research Colloquia
All but summer terms: W 4:00-5:00 p.m., Th 10:30-noon
Colloquia presented to the Department of Chemistry by scientists and
educators in the chemistry profession on Thursdays, and by graduate students
and others conducting research in chemistry and allied fields on Wednesdays as
needed. The course is required of all graduate students in chemistry in each
term. The course is not open for credit to undergraduates. The staff.
141. Seminar in Organic Chemistry
All but summer terms: W 8:00-10:00 p.m.
Study and discussion of current areas of interest in organic chemistry. The
format includes formal lectures, literature review sessions, and problem
solving sessions. This course is required of all graduate students planning or
performing research in organic chemistry in each term. The course is not open
for credit to undergraduates. The staff.
151. Physical Organic Chemistry (Identical to Chemistry 93)
06F: 9L Offered in alternate years or as needed
Modern theories of organic reaction mechanisms, particularly the use of
physical-chemical principles to predict the effect of changing reaction
variables, especially reactant structures, on reactivity. The structure,
stability, and reactivity of carbanions and carbocations, as well as SN1 and
SN2 reactions, are discussed.
Prerequisite: Chemistry 52 or 58, or permission of the instructor.
152. Advanced Organic Synthesis and Mechanisms
Offered as needed
Consideration of organic chemical reactions at an advanced level. Current
knowledge concerning synthetic methods, reaction mechanisms, reactive
intermediates, conformational analysis, and biosynthesis are discussed in the
context of modern organic chemistry.
Prerequisite: Chemistry 151, or permission of the instructor.
153. Chemistry of Natural Products
Offered as needed
A survey of the application of modern synthetic methods to the total
synthesis of natural products. Coverage will include retrosynthetic analysis
and synthetic planning and an overview of the preparation of a wide variety of
important natural products. Emphasis will be placed on student problem-solving
in the context of the synthesis of complex molecules.
Prerequisite: Chemistry 152, or permission of the instructor.
154. Molecular Orbital Concepts in Advanced Organic Chemistry
Offered as needed
Applications of molecular orbital theory to structural, spectroscopic, and
reactivity problems in organic chemistry. A variety of approaches to
approximate solutions of the Schr√δdinger equation for complex molecules will
be discussed from a practical viewpoint. Among other topics, aromaticity, the
theory of concerted reactions, and fundamentals of photochemistry will be
considered.
Prerequisite: Chemistry 151, and Chemistry 73 or the equivalent, or
permission of the instructor.
155. Enzyme Chemistry
Offered as needed
Consideration of enzyme catalyzed reactions, focusing on the structural
properties of proteins, model organic reactions, and the application of
kinetic, thermodynamic, and spectroscopic methods to elucidate enzyme reaction
mechanisms.
Offered on a tutorial basis to qualified students.
157. Topics in Advanced Organic Chemistry
Offered as needed
Treatment at an advanced level of one or more areas of organic chemistry.
The subject matter may vary from offering to offering; accordingly, the course
may be taken for credit more than once.
Offered on a tutorial basis to qualified students.
158. Spectrometric Analysis in Organic Chemistry
Offered as needed
An introduction to the theory underlying various spectrometric methods and
examples of their application to problems which interest organic chemists.
Infrared, Raman, ultraviolet/ visible, and nuclear magnetic resonance
spectroscopy will be considered, with special emphasis on the last. Students
will carry out computer-assisted analysis of complex static and dynamic NMR
spectra. Other methods which may receive brief attention are electron
paramagnetic resonance, photoelectron spectroscopy, optical rotatory
dispersion/circular dichroism, and mass spectrometry.
Prerequisite: Chemistry 151, and Chemistry 73 or the equivalent, or
permission of the instructor.
159. Chemistry of Heterocyclic Compounds
Offered as needed
An introduction to the chemical, physical, and spectroscopic properties of
heterocyclic compounds. Coverage will include reactions, synthesis,
stereo-chemistry, and unusual rearrangements. Attention will also be given to
natural product synthesis and to heterocycles of biological interest.
Prerequisite: Permission of the instructor.
160. Structure-Based Drug Design
Offered as needed
Principles of drug design based on protein and nucleic acid structures will
be covered including the chemical principles of protein/ligand interactions and
an introduction to medicinal chemistry. Topics will also include the selection
of a good drug design target and the techniques available to develop lead
inhibitors. Students will examine protein/ligand (drug) and nucleic acid/ligand
(drug) interactions through the literature and on graphics workstations to
develop an intuition for what makes a good inhibitor. Pertinent examples will
be studied extensively in class.
Prerequisite: Chemistry 52 or 58, Chemistry 41 or Biology 77, and Chemistry
67, or permission of the instructor.
161. Topics in Advanced Biophysical Chemistry
Offered as needed
Treatment at an advanced level of one or more areas of biophysical
chemistry. The subject matter varies from offering to offering; accordingly the
course may be taken for credit more than once.
Offered on a tutorial basis to qualified students.
256. Graduate Instruction in Teaching
06F, 07F: Arrange
A course in the methodology and practice of chemistry teaching at the
undergraduate college level. Topics such as laboratory supervision and safety,
grading issues, special needs students, lecturing and tutoring techniques, exam
preparation, and the teacher/student relationship will be discussed through
readings, class discussions, and student presentations. This course is a
prerequisite to the supervised undergraduate teaching requirement for the Ph.D.
degree in chemistry.
Required of entering graduate students. This course is not open for credit
to undergraduates. Milde, Veale.
257. Supervised Undergraduate Teaching in Chemistry
All terms: Arrange
Teaching in chemistry undergraduate courses under the supervision of a
faculty member. Normally students enrolled in this course teach alongside
faculty in undergraduate instructional laboratories. This course is open only
to graduate students; it may be elected for credit more than once.
Prerequisite: Chemistry 256 or previous teaching experience in undergraduate
chemistry courses. Chair and staff of the Department.
297. Graduate Investigation in Chemistry A
All terms: Arrange
An original and individual experimental or theoretical investigation beyond
the undergraduate level in one of the fields of chemistry. This course is open
only to graduate students; it may be elected for credit more than once. This
course carries one course credit and should be elected by students conducting
research and also electing two or more other graduate or undergraduate courses.
Chair and staff of the Department.
298. Graduate Investigation in Chemistry B
All terms: Arrange
An original and individual experimental or theoretical investigation beyond
the undergraduate level in one of the fields of chemistry. This course is open
only to graduate students; it may be elected for credit more than once. This
course carries two course credits and should be elected by students electing
only departmental colloquia in addition to research. Chair and staff of the
Department.
299. Graduate Investigation in Chemistry C
All terms: Arrange
An original and individual experimental or theoretical investigation beyond
the undergraduate level in one of the fields of chemistry. This course is open
only to graduate students; it may be elected for credit more than once. This
course carries three course credits and should be elected by students
conducting research exclusively in any one term. Chair and staff of the
Department.
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