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Chair: Ta Yuan Chang
Professors C. K. Barlowe (Biochemistry), C. E. Brinckerhoff (Medicine
and Biochemistry), T. Y. Chang (Biochemistry), C. N. Cole (Biochemistry and
Genetics), D. A. Compton (Biochemistry), J. C. Dunlap (Genetics and
Biochemistry), L. P. Henderson (Physiology and Biochemistry), G. E. Lienhard
(Biochemistry), J. J. Loros (Biochemistry and Genetics), R. A. Maue (Physiology
and Biochemistry), N. A. Speck (Biochemistry), B. L. Trumpower (Biochemistry),
W. T. Wickner (Biochemistry), L. A. Witters (Medicine and Biochemistry);
Professor Emeritus O. A. Scornik; Associate Professors B. A. Arrick (Medicine),
C. Brenner (Genetics and Biochemistry), D. R. Madden (Biochemistry), L. C.
Myers (Biochemistry), S. Supattapone (Biochemistry and Medicine); Associate
Professor Emeritus W. J. Culp; Assistant Professors H. N. Higgs (Biochemistry),
F. J. Kull (Chemistry).
Undergraduate students interested in a major program involving biochemistry
should refer to the major in Biochemistry and Molecular Biology offered by the
Department of Biological Sciences and to the major in Biophysical Chemistry
offered by the Department of Chemistry.
The Ph.D. in Biochemistry is administered by the Biochemistry Department of
Dartmouth Medical School. The courses listed below are primarily designed for
graduate students. The student should decide, in consultation with his/her
committee and course instructors, whether his/her background is appropriate for
the content of the course.
REQUIREMENTS FOR THE DOCTOR'S DEGREE (PH.D.)
To qualify for award of the Ph.D. degree, a student must fulfill the
following requirements:
1. Satisfactory completion of an intensive three-term core course entitled
“Biochemistry, Cell and Molecular Biology”, a one-term teaching assignment,
and a three-term course in laboratory biochemistry. The last will consist of
three small research projects, conducted in rotation with different faculty
members for periods of about three months each. To enroll in the three-term
“Biochemistry, Cell and Molecular Biology” course, students select
Biochemistry 101 (fall), Genetics 102 (winter), and Biochemistry 103
(spring).
2. Satisfactory completion of three other graduate-level courses in
biochemistry or related disciplines and a one-term teaching assignment.
3. Attendance at the weekly seminar series of the Program.
4. Participation in a journal club during fall, winter and spring terms
every year and in the weekly Research in Progress series
5. Satisfactory completion of an oral qualifying examination.
6. Satisfactory completion of a significant research project and preparation
of a thesis describing this research.
7. Successful defense of the thesis in an oral examination and presentation
of the work in a lecture.
For further information, see the Graduate Study Bulletin.
101. Biochemistry, Cell and Molecular Biology I
06F, 07F: 9L
The first term of a year-long graduate-level course in biochemistry, cell
and molecular biology. Topics include structure, function, and biosynthesis of
proteins, nucleic acids and lipids; enzyme kinetics and enzyme mechanisms; gene
regulation, transcription and translation; recombinant DNA technology; nuclear
trafficking, the secretory pathway, and endocytosis. Note that this course
begins earlier than the first official day of classes as noted in the Dartmouth
academic calendar and that students outside of the MCB program should contact
the Biochemistry Department for the date of the first lecture.
Not open to undergraduate students. Three lectures per week. Loros and
associates.
103. Biochemistry, Cell and Molecular Biology III
07S, 08S: 9L
The final term of a year-long graduate-level course in biochemistry, cell
and molecular biology. A continuation of Biochemistry 101 and Genetics 102.
Topics include cell signaling; neurobiology; metabolism; cytoskeleton, cell
shape and movement; mitosis and meiosis, regulation of cell growth and
division; oncogenes and tumor suppressor genes; proteosomes and protein
turnover; apoptosis.
Prerequisites: Biochemistry 101 and Genetics 102 or permission of the
instructor. Not open to undergraduate students. Three lectures per week.
Compton and associates.
110. Biochemical and Genetic Basis of Medicine (DMS1)
06F, 07F: 8
Cellular and molecular biology: Proteins, DNA and recombinant DNA, gene
expression, translation, membranes and the cell cycle. 65 hours of lecture and
discussion largely coincident with fall term, but note that this course
begins in early September.
Prerequisite: Permission of course director. Compton.
112. Metabolism (DMS1)
07W, 08W: 8
Intermediary metabolism of carbohydrates, lipids, amino acids, and
nucleotides. Regulatory mechanisms. Bioenergetics. Nutritional biochemistry,
energy and nitrogen balance, exercise. Biochemical functions of the major
mammalian tissues: digestive system, liver, red cells, muscle, adipocytes. 65
hours of lecture and discussion largely coincident with winter term.
Prerequisite: Permission of course director. Barlowe and associates.
114. Protein Targeting and Organelle Biogenesis (Identical to Biology
114)
07S: Arrange Offered in alternate years
A lecture and discussion course based on current research literature in the
field of protein targeting and biogenesis and assembly of cell organelles.
Topics will be introduced by a short lecture, which will be followed by
discussion of current research papers from the field. Study guides, consisting
of questions relating to the reading, will be used to focus discussion of
research papers.
Prerequisite: Permission of the instructor. Barlowe and associates.
118. Advanced Topics in Genetics and Molecular Genetics (Identical to
Genetics 118)
07S, 08S: Arrange
Each year Biochemistry 118 will focus on a different topic in genetics.
Emphasis on reading and analyzing material from the primary literature.
Prerequisite: Permission of the instructor. The staff.
132. Inorganic Biochemistry (Identical to Chemistry 92/132)
08S: Arrange Offered in alternate years
The role of metal ions in biological systems. Topics include metal ion
transport, storage and interaction with proteins and nucleic acids,
metalloproteins involved in oxygen transport and electron transfer,
metalloenzymes involved in activation of oxygen and other substrates, and
medicinal, toxicity and carcinogenicity aspects of metals, as well as inorganic
model chemistry of bioinorganic systems. Several physical methods, including
advanced spectroscopic techniques (EXAFS, Raman, ENDOR, NMR), are introduced
and their application to current research on the above topics is
considered.
Prerequisite: Biology 77 and Chemistry 64, or permission of the instructor.
Wilcox.
150. Neurosciences I: Molecular and Cellular Neuroscience (Identical to
Physiology 150)
Offered as requested.
This course is designed for students with a solid fundamental background in
Neuroscience. Students should have completed Medical Neuroscience or the
equivalent as a prerequisite. Students without this background who wish to take
this course may do so with permission of the instructor. Lectures will cover
both classical papers relevant to cellular and molecular neuroscience as well
as recent studies that highlight controversial and important findings in this
field. Students will be required to read and critique original research papers.
Discussion of these papers is an integral part of this course. Physiology
graduate students registering for advanced elective credit should register for
Physiology 118.
169. Supervised Teaching in Biochemistry
All terms: Arrange
This course is required to be taken at least once by all Biochemistry
graduate students, based on the assertion that an essential element of graduate
education is the experience gained in teaching other students. Such teaching
experience is of particular relevance to students interested in academic
careers. Students will conduct laboratory or discussion sessions in
undergraduate courses under the supervision of the course faculty. The faculty
and student teaching assistant work very closely to develop laboratory and
discussion assignments. In some cases, the students are encouraged to present
lectures for which they receive detailed feedback on their teaching style. In
all cases students will receive instruction on effective teaching techniques
through weekly preparation sessions. Topics for discussion include how to teach
the material, how to run a discussion, how to evaluate student responses, and
grading. Performance will be monitored throughout the term and appropriate
evaluation, coupled with detailed suggestions for improvement, will be
provided. This course is not open to undergraduates. The staff.
197. Graduate Research in Biochemistry A
All terms: Arrange
An original individual experimental or theoretical investigation beyond the
undergraduate level in biochemistry. This course is open only to graduate
students prior to passing their qualifying exam; it may be elected for credit
more than once. This course carries one course credit and should be elected by
students conducting research and also electing departmental colloquia and one
or more other courses. Chang and the staff of the Program.
198. Graduate Research in Biochemistry B
All terms: Arrange
An original individual experimental or theoretical investigation beyond the
undergraduate level in biochemistry. This course is open only to graduate
students prior to passing their qualifying exam; it may be elected for credit
more than once. This course carries two course credits and should be elected by
students electing only departmental colloquia in addition to research. Chang
and the staff of the Program.
199. Graduate Research in Biochemistry C
All terms: Arrange
An original individual experimental or theoretical investigation beyond the
undergraduate level in biochemistry. This course is open only to graduate
students prior to passing their qualifying exam; it may be elected for credit
more than once. This course carries three course credits and should be elected
by students conducting research exclusively in any one term. Chang and the
staff of the Program.
259-263. Graduate Research Colloquium in Biochemistry
F, W, S: Arrange
This course is required of all students during each term of residence,
except summer. An essential element of scientific training is in the critical
analysis and communication of experimental research in an oral format.
Evaluation will be based on quality of the work described, quality of critical
analysis, and on presentation style, including effective use of audio-visual
materials. Although minor variations in format exist among these two series,
normally these series meet weekly and all students will be required to
participate in at least one Journal Club presentation each term that describes
work from the current literature and one Research in Progress presentation each
academic year that describes their own research. This course is not open to
undergraduates. The staff.
Biochemistry 259, Actin Cytoskeleton
Biochemistry 260, Structural Biology
Biochemistry 261, Cancer Biology (W&S only)
Biochemistry 262, Medical Sciences (W&S only)
Biochemistry 263, Cell Biology
297. Graduate Research in Biochemistry A
All terms: Arrange
An original individual experimental or theoretical investigation beyond the
undergraduate level in biochemistry. This course is open only to graduate
students subsequent to passing their qualifying exam; it may be elected for
credit more than once. This course carries one course credit and should be
elected by students conducting research and also electing departmental
colloquia and one or more other courses. Chang and the staff of the
Program.
298. Graduate Research in Biochemistry B
All terms: Arrange
An original individual experimental or theoretical investigation beyond the
undergraduate level in biochemistry. This course is open only to graduate
students subsequent to passing their qualifying exam; it may be elected for
credit more than once. This course carries two course credits and should be
elected by students electing only departmental colloquia in addition to
research. Chang and the staff of the Program.
299. Graduate Research in Biochemistry C
All terms: Arrange
An original individual experimental or theoretical investigation beyond the
undergraduate level in biochemistry. This course is open only to graduate
students subsequent to passing their qualifying exam; it may be elected for
credit more than once. This course carries three course credits and should be
elected by students conducting research exclusively in any one term. Chang and
the staff of the Program.
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