Professor of Physiology Emeritus, Consultant in Medicine
Dr. McCann received her A.B. and Ph.D. degrees from the University of Connecticut and an M.S. from the University of Illinois. She spent a number of summers in residence at the MBL, Woods Hole, MA. Appointed Instructor in Physiology in 1959, she was promoted to Assis-tant (1961), Associate (1969) and then Professor of Physiology and Consultant in Medicine (1974) at Dartmouth Medical School. Research is currently focused on the activity of ion channels in breast cancer cells and cells in the immune system using patch clamp technology.
Dr. McCann is studying the mechanisms that link signal transduction at the cell membrane of B-lymphocytes to specific growth processes and to known functions (e.g., antibody depen-dent cellular cytotoxicity) of human monocyte derived macrophages. Other areas of research activity include investigations on the role of calcium in the regulation of the pacemaker in cardiac cells, links between ion channels and cell growth, and chemical regulation of neuroblastomas.
McCann, F.V., McCarthy, D.C., and Noelle, R.J. Interleukin 4 activates ion channels in B lymphocytes. Cellular Signalling 3:483-490, 1991.
McCarthy, D.C., Noelle, R.J., Gallagher, J.D. and McCann, F.V. Effects of cadmium on K+ currents in activated B lymphocytes. Cellular Signalling 5:417-424, 1993.
Gallagher, J.D., Noelle, R.J., and McCann, F.V. Potassium current suppression by anti-CD+O antibodies in human B cells. J. Gen. Physiol. 104:38, 1994.
Gallagher, J.D., Noelle, R.J., and McCann, F.V. Suppression of a pottasium current by mercury in human B lymphocytes. Cellular Signalling 7: 31-38, 1995.
Gallagher, J.D., Fay, M.J., North, W.G., and McCann, F.V. Ionic signals in T47D human breast cancer cells. Cellular Signalling 8: 4-10, 1996.
Thron, C.D. and McCann, F.V. Studies on the bradycardia and bursting rhythm caused by veratramine in the sinoatrial node of the guinea pig. J. Electrocardiology, in press.
Thron, C.D. and McCann, F.V. Pharmacological tests of the mechanism of the periodic rhythm caused by veratramine in the sinoatrial node of the guinea pig. British J. Gen. Pharmacology, in press.