Curriculum Vitae Brian William Pogue Associate Professor Thayer School of Engineering Dartmouth College 8000 Cummings Hall Hanover NH 03755-8000 http://engineering.dartmouth.edu/thayer/faculty/brianpogue.html http://www.dartmouth.edu/~biolaser office: (603) 646-3861 home: (802) 296-5727 fax: (603) 646-3856 email: Pogue@dartmouth.edu EDUCATION Bachelor of Science Honours Physics, York University, North York, ON, Canada, 1989 Master of Science Physics, York University, North York, ON, Canada, 1991 Thesis: Infrared Multiple-Photon Absorption of CF3H using 2-Frequency Excitation and Photoacoustic Detection. Doctor of Philosophy Medical Physics, McMaster University, Hamilton, ON, Canada, 1996 Thesis: Frequency-Domain Optical Spectroscopy and Imaging of Tissue. CURRENT ACADEMIC APPOINTMENTS Associate Professor Thayer School of Engineering, Dartmouth College, July 2001 - present. Research Scientist Massachusetts General Hospital, Wellman Laboratories of Photomedicine, Oct '00 - present. Associate Member Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, 1997- present. PAST ACADEMIC APPOINTMENTS Research Assistant Professor Thayer School of Engineering, Dartmouth College, Dec 1996 - June 2001. Visiting Research Fellow Massachusetts General Hospital, Wellman Laboratories of Photomedicine Harvard Medical School, Department of Dermatology, 1997-Oct 2000. Research Fellow Massachusetts General Hospital, Wellman Laboratories of Photomedicine Harvard Medical School, Department of Dermatology, March '95- Dec '96. EDITORIAL WORK Dekker Publications Editor of Handbook of Laser-Induced Fluorescence from Tissue Due to be published in 2002, Co-edited with Mary-Ann Mycek, Dartmouth College. Optics Letters Journal Topical Editor for Medicine and Biology manuscripts, 2000-2003 Advisory Editor for Optics Letters, 1997-2000.. Optical Soc. of America OSA conference organizer, Photon Migration Meeting April 2000. Photon Migration Meeting, April 2001. Guest Editor Optics Express, April 1999, Medical Physics Aug. 1999, Aug 2000. PROFESSIONAL MEMBERSHIPS & COMMITTEES Conference committees, Optical Society of America Biomedical Topical conferences on Advances in Optical Imaging and Photon Migration, Miami Beach, FL, April 2-5, 2000. and April 14-17, 2002. Thayer School of Engineering, M.S./Ph.D. Committee, summer 2001 - present. Thayer School of Engineering, Adjunct and Research Faculty Committee, summer 2001 - present. Board member of the Professional Information and Clincal Relations Committee in the American Association of Physicists in Medicine (AAPM), 1996 - Sept. 2000. Irradiator Safety Committee member, NCCC, Dartmouth Hitchcock Medical Center, 1997- present. Member of the American Association for the Advancement of Science (AAAS), 2000-present. Member of the IEEE Engineering in Medicine & Biology Society (IEEE EMBS), 2000-present Member of the International Society for Oxygen Transport to Tissue (ISOTT), 1999-present. Member of the International Society for Radiation Research (ICRR), 1999-present. Member of the Optical Society of America (OSA) 1996-present. Member of the International Society for Photo-optical Engineering (SPIE), 1995-present. Member of the American Association of Physicists in Medicine (AAPM), 1992- present. AWARDS Engineering Foundation Conference Fee Waiver for invited speakers, 1999. Engineering Foundation Conference Fellowship Award 1997. Gordon conference competetive award for post-doctoral registrants, 1996. Travel award for invited speakers Society of Photo-Optical Instrumentation Engineers, 1996 & 1997. Hamilton Civic Hospitals Radiology Research Presentation Prize, 1992. York University Entrance Scholarship, full tuition scholarship 1989. COURSES TAUGHT Introduction to Biomedical Engineering, biomed. optics section - Dartmouth College, spring 1999, spring 2000. Electromagnetic Fields and Waves ENGS120 - Dartmouth College, Winter 2002. INVITED CONFERENCE TALKS 1. "Frequency-domain spectroscopy: testing and error assessment. American Society of Photobiology, Washington DC., July 1995. 2. "A study of dosimetry for pulsed-laser photodynamic therapy" Society of Photo-optical Instrumentation Engineers- Biomedical Optics Conference (SPIE- BiOS), San Jose CA, January 1996. 3. "Quantitative fluorescence measurements from tissue using confocal detection" Society of Photo-optical Instrumentation Engineers- Biomedical OpticsConference (SPIE- BiOS), San Jose CA, January 1997. 4. "Examination of detector size and imaging geometry for frequency-domain diffuse optical tomography of breast tissue" IEEE- Engineering in Medicine and Biology Society EMBS Conference, Chicago IL, 1997. 5. "Diffuse optical tomography for breast cancer diagnosis", Optical Society of America General Meeting, Baltimore MD, 1997. 6. "Measurement of photosensitizer triplet state quantum yield in vivo", Optical Society of America General Meeting, Baltimore MD, 1997. 7. "Hemoglobin imaging of breast cancer with near-infrared diffuse tomography", American Society of Photobiology, Washington, DC., July 1999. 8. "Morphologic feature detection for diagnosis of cervical displasia", United Engineering Foundation Meeting, Kona Hawaii, July 1999. 9. "Diffuse optical tomography for breast cancer diagnosis", National Institutes of Health Inter-Institute workshop on Optical Imaging in Medicine, Arlington VA, September, 1999. 10. "Photosensitizer quantitation by microsampling of tissue fluorescence: in vivo testing" Society of Photo-optical Instrumentation Engineers- Biomedical Optics (SPIE- BiOS), San Jose CA, January 2000. 11. "Breast Imaging and Spectroscopy" panel discussion in the Optical Imaging Workshop from Bench to Bedside at the National Institutes of Health, Bethesda, MD, September, 2000. 12. "Multi-spectral near-infared imaging of breast cancer tumors" Optical Society of America General Meeting, Providence RI, October 24 2000. 13. "Hemoglobin Tomography for Breast Cancer Imaging" United Engineering Foundation Meeting, Banff, AB Canada, July 2001. 14. "Microscopic Heterogeneity in Deposited Dose during PDT treatments" European Society of Photobiology, Lillehammer Norway, Sept 3-8, 2001. 15. "Basic Biophysical Studies For PDT Dosimetry" European Society of Photobiology, Lillehammer Norway, Sept 3-8, 2001. 16. "Multispectral Near-Infrared Tomography for Hemoglobin-Based Imaging of Breast Cancer" (Federation of Applied Chemistry and Spectrosocpy Societies, Oct. 7 - 12, 2001, Detroit, MI. PEER-REVIEWED PUBLICATIONS McBride, T. O., Pogue, B. W., Jiang, S., Österberg, U. L., Paulsen, K. D., Poplack, S. P., "Multi-spectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast", Journal of Biomedical Optics (in press), 2002. Pogue, B. W., O'Hara, J. A., Goodwin, I. A., Fournier, G. P.,Wilmot, C. J., Akay, A. R. and Swartz, H. M., "Tumor pO2 Changes during Photodynamic Therapy Depend upon Photosensitizer Type and Time After Injection." Comparative Biochemistry and Physiology, Part B: Biochemistry & Molecular Biology (in press), 2001. Pogue, B. W., Pitts, J. D., Mycek, M-A., Sloboda, R. D., Wilmot, C. M., Brandsema, J. F., O'Hara, J. A., "In Vivo NADH Fluorescence Monitoring as an Assay for Cellular Damage in Photodynamic Therapy" Photochemistry and Photobiology, 74(6), 817-824, 2001. Pogue, B. W., Braun, R., Lanzen, J., Erickson, C., Dewhirst M. W., "Acute Tissue (pO2) and Blood Flow Dynamics during Photodynamic Therapy with Verteporfin." Photochemistry and Photobiology, 74(5), 2001. Pogue, B. W., Kaufman, H. B., Zelenchuk, A., Harper, W., Burke, G. C., Burke, E. E., Harper, D. M., "Analysis of acetic acid-induced whitening of high-grade squamous intraepithelial lesions" Journal of Biomedical Optics, 6(4), 397-401, 2001. Lee , C. C., Pogue, B. W., Burke, G. C., Hoopes, P. J., "Comparison of photosensitizer (AlS2Pc) quantitation techniques : In situ fluorescence microsampling versus tissue chemical extraction", Photochemistry and Photobiology, 74(3), 453-460, Sept. 2001. Pogue, B. W., Zhu, H., Nwaigwe, C., Mcbride, T. O., Osterberg, U. L., Paulsen, K. D., and Dunn, J. F., Hemoglobin imaging with hybrid magnetic resonance and Near-Infrared Diffuse Tomography, in: Oxygen Transport to Tissue XXI. (eds: Dunn, J.F. and Swartz, H.M.), Pabst, Lengerich. (in press, due March 2001). McBride, T. O., Pogue B. W., Österberg, U. L., and Paulsen, K. D., Strategies for Absolute Calibration of Near Infrared Tomographic Tissue Imaging , in: Oxygen Transport to Tissue XXI. (eds: Dunn, J.F. and Swartz, H.M.), Pabst, Lengerich. (in press, due March 2001). Pogue, B. W., White, E., Osterberg, U. L., Paulsen, K. D., "Absorbance of opaque microstructure in optically diffuse media", Applied Optics 40(25) 4616-4621, September 1, 2001. McBride, T. O., Pogue, B. W., Jiang, S., Österberg, U. L., Paulsen, K. D., Poplack, S. P., "Initial studies of in vivo absorbing and scattering heterogeneity in near-infrared tomographic breast imaging" Optics Letters, 26(11), 822-824, (2001). Meaney, P. M., Paulsen, K. D., Pogue, B. W., Miga, M. I., Microwave Imaging utilizing phase unwrapping to reduce recovered object ambiguity, IEEE transactions on Medical Imaging, 20(2) 104-116, 2001. McBride, T. O., Pogue, B. W., Jiang, S. Österberg, U. L., Paulsen K. D., "Development and Calibration of a Parallel Modulated Near-Infrared Tomography System for Hemoglobin Imaging In Vivo" Review of Scientific Instruments 72(3) 1817-24, March 2001. Pogue, B. W., Ortel, B., Chen, N., Redmond R. W., Hasan, T, "Photobiological and photophysical study of the phototoxicity of two chlorins", Cancer Research 61, 717-724, Jan. 29, 2001. Pogue, B. W., Geimer, S., McBride, T. O., Jiang, S., Österberg, U. L., Paulsen, K. D., "3-D Simulation of Near-Infrared Diffusion in Tissue: Boundary Conditions and Geometry Analysis For a Finite Element Reconstruction Algorithm" Applied Optics, 40(4), 588-600, Feb. 2001. Pogue, B. W., O'Hara, J. A., Wilmot, C. M., Paulsen, K. D., Swartz, H. M., "Estimation of capillary oxygen concentration in RIF-1 tumors through model-based interpretation of hypoxia and Eppendorf measurements", Radiation Research 155(1 part 1), 15-25, 2001. Pogue, B. W., McBride, T. O., Osterman, S., Poplack, S., Osterberg, U. And Paulsen, K. D. Quantitative Hemoglobin Tomography with Diffuse Near-Infrared Spectroscopy: Pilot Results in the Breast., Radiology, 218(1) 261-6, Jan. 2001. Pogue, B. W., Willscher, C., McBride, T. O., Osterberg, U. L., Paulsen, K. D., "Contrast-detail analysis for detection and characterization with near-infrared diffuse tomography.", Medical Physics, 27(12), 2693-2700 (2000). Pogue, B. W., Paulsen, K. D., Kaufman, H., Abele, C., Calibration of near infrared frequency-domain tissue spectroscopy for absolute absorption coefficient quantitation in neonatal head-simulating phantoms, Journal of Biomedical Optics, 5(2), 185-193 (2000). Pogue, B. W., Mycek, M. A., Harper, D., Image analysis for discrimination of cervical neoplasia in colposcopy., Journal of Biomedical Optics 5(1), 72-82 (2000). Tosteson, T. D., Pogue, B. W., Demidenko, E., McBride, T. O., Paulsen, K. D. Confidence maps and confidence intervals for near-infrared images in breast cancer. IEEE Transactions on Medical Imaging, 18(12), 1188-93 (1999). McBride, T. O., Pogue, B. W., Poplack, S. B., Gerety, E. D., Osterberg, U. L., Pauslen, K. D., Spectroscopic diffuse optical tomography for quantitatively assessing hemoglobin concentration and oxygenation in breast tissue. Applied Optics 38(25), pp5480-90, 1999. Pogue, B. W., McBride, T. O., Prewit, J., Osterberg, U. L., Paulsen, K. D., Spatially variant regularization improves diffuse optical tomography. Applied Optics, 38 (13) pp2950-2961, 1999. Pogue B. W., Momma T., Wu H., Hasan T. Transient absorption in vivo during photodynamic therapy with pulsed laser light. British Journal of Cancer, 80(3-4) pp.344-351, 1999. Pogue BW, McBride T. O., Osterberg U. L. and Paulsen K. D. Comparison of imaging geometries for diffuse optical tomography of tissue. Opt Express 4(8), 270-286, 1999. Testorf, M., Osterberg, U. L., Pogue, B. W., Paulsen, K. D., Sampling of time and frequency domain signals in Monte Carlo simulations of photon migration. Applied Optics, 38(1), 236-245, 1999. Pogue, B. W., Redmond R. W., Trivedi, N, Hasan, T. Photophysical Properties of Tin Ethyl Etiopurpurin I (SnET2) and Tin Octaethylbenzochlorin (SnOEBC) in solution and bound to albumin. Photochemistry & Photobiology 68(6), 809-15, (1998). Dunn, J. F., Zaim-Wadghiri, Y., Pogue, B.W., Kida, I. BOLD MRI vs. NIR spectrophotometry. Will the best technique come forward?. Advances in Experimental Medicine & Biology. 454:103-13, 1998. Pogue, B. W. and K. D. Paulsen, High resolution near infrared tomographic imaging simulations of rat cranium using apriori MRI structural information. Optics Letters 23(21), 1716-8, (1998). Pogue, B. W. and Gregory Burke, Fiber optic bundle design for non-invasive quantitative fluorescence measurements from tissue-simulating media. Applied Optics, 37(31) 7429-7436 (1998). Pogue, B. W., Testorf, M., McBride, T., Osterberg,U., Paulsen, K. Instrumentation and design of a frequency-domain diffuse optical tomography imager for breast cancer screening. Optics Express, 1(13), 394-403 (1997). Pogue B W, Lilge L, Patterson M S, Wilson B C, Hasan T The absorbed photodynamic dose examined from pulsed and cw laser light using tissue simulating dosimeters. Applied Optics, 36, 7257-7269, 1997. Pogue B W, Hasan T Fluorophore quantitation in scattering biologic media by confocal detection. IEEE J. Quant. Electr.,2(4), 959-964, 1997. Paithankar D Y, Chen A U, Pogue B W, Patterson M S, Sevick-Muraca E M 1996 Imaging of fluorescent yield and lifetime from multiply scattered light re-emitted from tissues and other random media. Applied Optics 36, 2260-2272, 1997. Pogue B W, Hasan T A theoretical examination of light fractionation and dose rate effects in photodynamic therapy. Radiation Research, 147, 551-559,1997. Pogue B W, Patterson M S, Assessment of a wavelength tunable frequency-domain system for non-invasive tissue spectroscopy. Journal of Biomedical Optics , 1 (3), 311-323, 1996. Jiang H, Paulsen K D, Osterberg U L, Pogue B W, Patterson M S Optical image reconstruction using frequency-domain data: Simulations and Experiments. Journal of the Optical Society of America A: Optics and Image Science 13, 253-266, 1996. Jiang H, Paulsen K D, Osterberg U L, Pogue B W, Patterson M S Simultaneous reconstruction of optical absorption and scattering maps in turbid media from near-infrared frequency-domain data Optics Letters 20, 2128-2130, 1995. Pogue B W, Patterson M S, Jiang H, Paulsen K D Initial assessment of a simple system for frequency-domain diffuse optical tomography. Physics in Medicine and Biology 40, 1709-1729, 1995. Pogue B W, Patterson M S Frequency-domain optical absorption spectroscopy of finite tissue volumes using diffusion theory. Physics in Medicine and Biology 39, 1157-1180, 1994. Patterson M S, Pogue B W Mathematical model for time-resolved and frequency-domain fluorescence spectroscopy in biological tissues. Applied Optics 33, 1963-1974, 1994. Alonso E, O'Neill JA, Pateopol L, Pogue B, Vibrationally excited-state absorption of CF3D using 2-frequency infrared multiphoton absorption, , Journal of Physics B-Atomic Molecular and Optical Physics 27: (5) 913-924 (1994). O'Neill J A, Pateopol L, Pogue B Multiphoton absorption measurments in CF3H. Journal of Physics B: Atomic, Moelcular and Optical Physics 25, 3335-3344, 1992. CONFERENCE PROCEEDINGS & ABSTRACTS Pogue, B. W., Poplack, S. P., Jiang, S., Dehghani, H., Wells, W. A., Paulsen, K. D. "Multispectral Near-Infrared Tomography For Hemoglobin-Based Imaging Of Cancer In Vivo" Progress in Electromagnetics Research Symposium, Cambridge, Massachusetts, July 1-5, 2002. Pogue, B. W., Pitts, J. D., Mycek, M.-A., Sloboda, R. D., Wilmot, C. M., Brandsema, J. F., O'Hara, J. A. "Endogenous Fluorescence Monitoring In Vivo as an Assay for Cellular Damage in Photodynamic Therapy" Optical Society of America , Advances in Biomedical Optical Spectroscopy and Diagnostics (BOSD), Miami Beach, FL, April 7-10, 2002. Pogue, B. W., Wells, W. A., Jiang, S., Poplack, S. P., Tosteson, T. D., and Paulsen, K. D. "Validation of Hemoglobin Concentration Imaging of Breast Tumors Through Comparison with Pathological Assessment" Optical Society of America Advances in Optical Imaging and Photon Migration (AOIPM), Miami Beach, FL, April 7-10, 2002. Paulsen, K. D., Li, D., Meaney, P., Pogue, B. W., Hartov, A., and Tosteson, T. D. "Breast Imaging Using the Electromagnetic Spectrum from Near Infrared to Near DC" Optical Society of America, Advances in Optical Imaging and Photon Migration (AOIPM), Miami Beach, FL, April 7-10, 2002. Srinivasan, S., Pogue, B. W., Jiang, S., Dehghani, H. and Paulsen, K. D. "Hemoglobin Oxygen Saturation Tomography: Calibration in Phantom Studies and Patient Data Analysis" Optical Society of America , Advances in Optical Imaging and Photon Migration (AOIPM), Miami Beach, FL, April 7-10, 2002. Song, S., Pogue, B. W., Jiang, S., McBride, T. O., Tosteson, T. D., and Paulsen, K. D. "Statistical Analysis of Non-linearly Reconstructed Near-Infrared Tomographic Images" Optical Society of America, Advances in Optical Imaging and Photon Migration (AOIPM), Miami Beach, FL, April 7-10, 2002. Dehghani, H., Pogue, B. W., and Paulsen, K. D. "3-D Image reconstruction for near-infrared breast imaging" Optical Society of America Advances in Optical Imaging and Photon Migration (AOIPM), Miami Beach, FL, April 7-10, 2002. Jiang, S., Pogue, B. W., McBride, T. O. and Paulsen, K. D. "Dynamic Hemoglobin Concentration Imaging Using A Simultaneous Two Wavelength Near-infrared Diffuse Optical Tomography System" Optical Society of America, Advances in Optical Imaging and Photon Migration (AOIPM), Miami Beach, FL, April 7-10, 2002. Pogue, B. W., O'Hara, J. A., Wilmot, C. M., Swartz, H. M. "Photodynamic therapy induces acute reduction in metabolic oxygen consumption and increases RIF-1 tumor pO2" International Congress of Radiation Research, Reno NV, April 20-24. Pogue, B. W., O'Hara, J. A., Wilmot, C. J. and Swartz, H. M. "Tumor and cellular metabolism changes during photodynamic therapy" Electron Paramagnetic Resonance Viable Systems, 9th International Conference, Hanover NH, Sept 2001. Vishwanath, K., Pogue, B. W., Mycek, M-A. "Experimental and Computational Studies of Fluorescence Lifetimes and Spectra from Scattering Tissue Phantoms," Proceedings of the OSA Conference on Lasers and Electro-Optics (CLEO), Long Beach CA, May 2002. Vishwanath, K., Pogue, B. W., Mycek, M-A. Modeling Time-Resolved Fluorescence in Turbid Media via Monte-Carlo Simulations", Optical Society of America Annual Meeting, Longbeach CA, Oct 2001. Pogue, B. W., Paulsen, K. D. and Dunn, J. F., "Hybrid Magnetic Resonance and Near-Infrared Diffuse Tomography for Hemoglobin Imaging in the Rat Cranium" High Resolution Imaging of Small Animals, Rockville MD, Sept 2001. Pogue, B. W., Braun, R., Dewhirst, M. W., "Microscopic Heterogeneity Of Dose Deposition: Monitoring The Oxygen Dynamics During PDT" European Society of Photobiology, Lillehammer Norway, Sept 2001. Pogue, B. W., O'Hara, J. A., Hoopes, P. J., Hasan, T., "Basic Biophysical Studies For PDT Dosimetry" European Society of Photobiology, Lillehammer Norway, Sept 2001. Pogue, B. W., O'Hara, J., Swartz, H. M., "Oxygen Dynamics During PDT: Comparison Of In Vivo And In Vitro Effects For Vascular Versus Cellular Targeting Sensitizers" International Conference on Photodynamic Medicine, Vancouver BC Canada, June 5-9, 2001. Pogue, B. W., O'Hara, J. A., Wilmot, C., Swartz, H. M., "Photodynamic therapy affects and is affectedby oxygen supply in vivo" Congress of the Radiation Research Society, San Juan, Peurto Rico (April, 2001). Pogue, B. W., Fournier, G. P., Akay, A. R., Lee, C. C., Burke, G. C. and Hoopes, P. J. "Monitoring intrinsic photosensitizer photobleaching in vivo by micro-sampling the fluorescence signal." Proceedings of the International Society for Optical Engineering (SPIE): Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X, Vol. 4248 72-82, San Jose CA, Jan 2001. Pogue, B. W., Braun, R., Lanzen, J., Erickson, C., Dewhirst M. W., "Acute Tissue (pO2) and Blood Flow Dynamics during Photodynamic Therapy with Verteporfin." Proceedings of the International Society for Optical Engineering (SPIE): Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X, Vol. 4248 144-149, San Jose CA, Jan 2001. McBride, T. O., Pogue, B. W., Jiang, S., Österberg, U. L., Wells, W., Paulsen, K. D."A Preliminary Study of Near-infrared Tomographic Imaging of Heterogeneous Media: Simulations and Experiments in Ex Vivo Breast Tissue" Proceedings of the International Society for Optical Engineering (SPIE): Optical Tomography and Spectroscopy of Tissue, Vol. 4250, pp204-210, San Jose CA, Jan 2001. Pogue, B. W., McBride, T. O., Jiang, S., Österberg, U. L., Paulsen, K. D."Analysis of Circular Source-Detector Geometries for Near-Infrared Tomographic Imaging" Proceedings of the International Society for Optical Engineering (SPIE): Optical Tomography and Spectroscopy of Tissue, Vol. 4250, pp412-418, San Jose CA, Jan 2001. Pogue, B. W., O'Hara, J. A., Wilmot, C., Swartz, H. M. "Assesment of oxygen dosimetry in photodynamic therapy" Congress of the Radiation Research Society, Albequeqe NM (April, 2000). Lee, C. C., Pogue, B. W., Strawbridge, R. R., Moodie, K. L., Burke, G. C., O'Hara, J. A., and PJ Hoopes, "Noninvasive comparison of intratumoral vs. systemic administration of photosensitizer drug" Congress of the Radiation Research Society, Albequeqe NM (April, 2000). Pogue, B. W., Lee, C. C., O'Hara, J.A., Hoopes P.J., "Photosensitizer uptake quantitation by microsampling of tissue fluorescence: in vivo testing" (invited talk), Proceedings of SPIE, 3914A pp33-39 (2000). Pogue, B.W., Paulsen, K. D., O'Hara, J. A., Hoopes, P.J., Swartz, H. M., "Modeling of tumor oxygen micro-heterogeneity for photodynamic therapy dosimetry" In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IX, T. J. Douherty Ed., Proceedings of SPIE 3909 pp104-112 (Jan, 2000). Pogue, B. W., McBride, T. O., Poplack, S., Österberg, U. L., Paulsen, K. D."Imaging hemoglobin concentration and oxygen saturation in the female breast with near-infrared diffusion tomography" Proceedings of the Inter-institute Workshop on In Vivo Optical Imaging at the NIH, A. Gandjbakhche Ed., Optical Society of America, Washington DC 1999. Pogue, B. W., O'Hara, J. A., Liu, K. J., Hasan, T, Swartz, H., "Photodynamic treatment of the RIF-1 tumor with verteporfin with online monitoring of tissue oxygen using electron paramagnetic resonance oximetry" Proceedings of SPIE Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, Vol. 3601, p. 108-114, , Eds. Steven L. Jacques; Gerhard J. Mueller, A. Roggan; D. H. Sliney. 1999. Keith D. Paulsen, Brian W. Pogue, Troy O. McBride, Ulf. L. Österberg, "Design and Testing of a Near-Infrared Computed Tomography Device for Breast Tumor Characterization" BioMedical Engineering Society and the IEEE Engineering in Medicine and Biology Society (BMES/EMBS) Atlanta, GA, Oct 16-19, 1999. Lee, C. C., Pogue, B. W., Strawbridge, R., Burke, G., Hoopes, P. J., "Biodistribution studies for photodynamic therapy" Int. Congress of the Radiation Research, Dublin, IR (July, 1999). Brian W. Pogue, Gregory C. Burke, John Weaver, and Diane M. Harper, "Multi-wavelength digital colposcopy to aid early detection of cervical cancer " In Biomedical Optical Spectroscopy And Diagnostics / Therapeutic Laser Applications, p118, Trends in Optics and Photonics Series Vol. 22 (OSA: 1998). Pogue, B. W., McBride, T. O., Nwaigwe, C., Dunn, J. F., Ulf L. Osterberg, Keith D. Paulsen, K. D., Near-infrared diffuse tomography with apriori MRI structural information: testing a hybrid image reconstruction methodology with functional imaging of rat cranium. Proceedings of SPIE 3597, 484-492, 1999. Troy O. McBride, Brian W. Pogue, Ulf L. Österberg, and Keith D. Paulsen, Image reconstruction of continuously varying objects and simulated breast cancer lesions. Proceedings of SPIE 3597, 514-525, 1999. Paulsen, K., Hartov, A., Osterman, S., Meaney, P, Chang, J., Pogue, B., McBride, T., Osterberg, U., Electromagnetic tissue monitoring and assessment for therapeutic and diagnostic medicine. Proceedings of SPIE 3594, (1999). Markus, T., Osterberg, U. L., Pogue, B. W., Paulsen, K. D. "Comparison of sampling methods for time and frequency domain signals in Monte Carlo simulations of light migration in turbid material." Proceedings of SPIE Photon Propagation in Tissues IV, Eds. D. A.Benaron; B. Chance; M. Ferrari; M. Kohl., Vol. 3566, p. 10-19, (1998). Pogue B. W. and Burke G. C., Quantitative Fluorophore Detection from Tissue-Simulating Media Using a New Fiber Optic Probe. Proceedings of Biomedical Optical Spectroscopy and Diagnostics, Optical Society of America, Orlando FL (March 1998). Pogue B. W., Burke G. C., Weaver J., Harper D. M., Development of a Spectrally-Resolved Colposcope for Early Detection of Cervical Cancer. Proceedings of Biomedical Optical Spectroscopy and Diagnostics, Optical Society of America, Orlando FL (March 1998). Pogue B. W., Testorf M., Osterberg U. L., Paulsen K. D. Quantitative Imaging in Frequency-Domain Diffuse Optical Tomography for Breast Cancer Detection. Advances in Optical Imaging and Photon Migration, Optical Society of America, Orlando FL (March 1998). Pogue B. W., Chen N., Luedemann H. C., Redmond R. W., Hasan T.. Comparitive Triplet State Yield Measurement In Vitro. Proceedings of Therapeutic Laser Applications, Optical Society of America, Orlando FL (March 1998). Pogue, B. W., Jiang, H., Paulsen, K. D., Osterberg, U. 1997 Examination of detector size and imaging geometry for frequency-domain diffuse optical tomography of breast tissue. (Invited paper) Proceedings of IEEE conference, Chicago (in press). Pogue B W, Redmond R W, Lilge L, Wilson B C, Hasan T 1997 Measurement of the triplet state yield of photosensitizer in tissue. Proceedings of SPIE 2972 , 168-172. Pogue B W and Hasan T 1997 Quantitative fluorescence measurements from tissue using confocal detection. (Invited paper) Proceedings of SPIE 2975, 202-207. Pogue B W, Redmond R W, Hasan T 1996 A study of dosimetry for pulsed-laser photodynamic therapy (Invited paper) Proceedings of SPIE 2681, 275-284. Pogue B W, Patterson M S 1995 Frequency-domain spectroscopy: testing and error assessment. Proceedings of the American Society of Photobiology. Pogue B W, Patterson M S, Farrell T J 1995 Forward and inverse calculations for 3-D frequency-domain diffuse optical tomography, Proceedings of SPIE 2389, 328-339. Pogue B W, Patterson M S 1994 Forward and Inverse calculations for near-infrared imaging using a multigrid finite difference method, OSA proceedings on Advances in Optical Imaging and Photon Migration ed. R. R. Alfano, March 1994, Orlando, Florida. Patterson M S, Pogue B W 1994 Effect of finite volumes on noninvasive frequency-domain measurements of tissue optical properties, OSA proceedings on Advances in Optical Imaging and Photon Migration ed. R. R. Alfano, March 1994, Orlando, Florida. Pogue B W, Patterson M S, Perturbation calculations of photon density waves interfering in an inhomogeneous tissue-simulating medium, OSA proceedings on Advances in Optical Imaging and Photon Migration ed. R. R. Alfano, March 1994, Orlando, Florida. Patterson M S, Pogue B W, Wilson B C, Computer simulation and experimental studies of optical imaging with photon density waves, Medical Optical Tomography: Functional Imaging and Monitoring. ed. G. Muller, SPIE Institute series, 1993, Bellingham, WA. Wilson B C, Patterson M S, Pogue B W 1993 Instrumentation for in vivo tissue spectroscopy and imaging, Proceedings of SPIE 1892, 132-147 INVITED REVIEWS Pogue B. W. Biomedical diffuse optical tomography - Introduction. Opt Express 4(8) pp. 230-230, 1999, (http://www.opticsexpress.org/topbiframe.htm). Pogue, B. W., "Biomedical Photo-chemistry and Photo-imaging In Vivo", IEEE Lasers and Electro-optics Society newsletter, 14(2), pp3-7, April 2000, ( http://www.ieee.org/organizations/pubs/newsletters/leos/apr00/biomed.htm). 1 11