The Hasan Program Project
Molecular Response and Imaging-based Combination Strategies for Optimal PDT
Cores
The Administrative Core (Core A) will play a key role in Program integration and ensuring that the whole is greater than the sum of its parts. Dr. Hasan will provide the leadership to keep the Cores and the Projects moving towards their respective goals. A wiki-based website will be a key feature of the Program for data exchange among the investigators, and also for data and resource sharing with the broader research community. The addition of Dr. Brian Pogue as Co-Director for Core A will further augment the integration of the Program.
Core B, based at the Wellman Center for Photomedicine, will provide a research platform and service for molecular pathology, and statistics, and will be used by all four Projects in the Program to a comparable extent. Dr. Gary Tearney, MD, PhD (MGH), will head this Core and oversee the smooth running of the Core as a whole. Dr. Zhiming Mai, who has gained substantial experience in imaging and pathology techniques, will assist him for the day-to-day operations, and Dr. Mai will be in regular contact with Core B representatives at non-Wellman sites. Core B will also play a collaborative role in experiments aimed at developing new microscopy and imaging techniques.
Core C, headed by Dr. Brian Pogue and supported at the Wellman by Dr. Sung Chang, will provide a platform and expertise base for imaging and dosimetry that is specific to the Projects in the Program. Core C will provide support for all four Projects for imaging, developing new photophysical instrumentation, molecular imaging, and the translation of technologies to or from industry. The Core has an external advisory board and will provide a network of technical and translational expertise for both commercial and non-commercial distribution of new IP and new methodologies.
The following table depicts the distribution of cores usage by each project.
| Core | Title | Project 1 | Project 2 | Project 3 | Project 4 |
|---|---|---|---|---|---|
| A | Administrative Core | 25% | 30% | 20% | 25% |
| B | Biological Model, Molecular Phathology and Biostatistics | 34% | 15% | 33% | 18% |
| C | In vivo Imaging, Dosimetry and Technology Transfer | 20% | 30% | 30% | 20% |
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