Tissue Characterization with MR Relaxation Times

MR signal intensities are influenced by free water content and the MR relaxation times. By quantifying these variables, we can distinguish the dominent factor responsible for a change in signal intensity during the onset of a disease or with respect to interpretation of a complex structure. This information is required to properly interpret changes in the MR image with respect to identification of disease.

In collaboration with Dr. Douglas Goodwin [Department of Radiology, Dartmouth Medical School], we are concentrating on three conditions: cartilage structure in the joints and the onset of arthritis; brain and spine structure during demyelination associated with MS; and assessment of tissue oxygenation using blood oxygen sensitive imaging.