Myers Lab Publications

Myers Lab
at Dartmouth

Selected Publications

Articles:

Bjornsdottir, G. and Myers, L.C. (2008) Minimal components of the RNA polymerase II transcription apparatus determine the consensus TATA box. Nucleic Acids Res. 36(9):2906-16. Epub 2008 Apr 1.

Baidoobonso, S.M., Guidi, B.W., and Myers, L.C. (2007) Med19(Rox3) regulates Intermodule interactions in the Saccharomyces cerevisiae Mediator complex. J. Biol. Chem. 282(8):5551-9. Epub 2006 Dec 27.

Nair, D.; Y. Kim; Myers, L.C. "Mediator and TFIIH govern carboxyl-terminal domain-dependent transcription in yeast extracts." J. Biol. Chem. 280:33739-48 (2005). [PDF]

Guidi, B.W.; Bjornsdottir, G.; Hopkins, D.C.; Lacomis, L.; Erdjument-Bromage, H.; Tempst, P.; Myers L.C. "Mutual Targeting of Mediator and the TFIIH Kinase Kin28." J. Biol. Chem. 279:29114-20 (2004). [PDF]

Myers, L.C. (*); Lacomis, L.; Erdjument-Bromage, H.; Tempst, P. "The yeast capping enzyme represses RNA polymerase II transcription." Mol. Cell 10:883-94 (2002). (*Corresponding Author). [PDF]

Lin, Y.; Dotsch, V.; Wintner, T.; Peariso, K.; Myers, L.C.; Penner-Hahn, J.E.; Verdine, G.L.; Wagner, G. "Structural basis for the functional switch of the E. coli Ada protein." Biochemistry 40:4261 (2001).

Myers, L.C.; Kornberg, R.D.; "Mediator of transcriptional regulation." Annu Rev Biochem. 69:729 (2000). [PDF]

Dotson, M.R,; Yuan, C.X.; Roeder, R.G.; Myers, L.C.; Gustafsson, C.M.; Jiang, Y.W.; Li, Y.; Kornberg, R.D.; Asturias, F.J. "Structural organization of yeast and mammalian mediator complexes." Proc. Natl. Acad. Sci. U.S.A. 97:14307 (2000).

Myers, L. C. (*); Gustafsson, C. M. (*); Hayashibara, K. C.; Brown, P. O.; Kornberg, R. D.; "Mediator Protein Mutations that Selectively Abolish Activated Transcription" Proc. Natl. Acad. Sci. 96, 67 (1999). (*Equal Contribution). [PDF]

Lorch, Y.; Beve, J.; Gustafsson, C. M.; Myers, L. C.; Kornberg, R. D.; "Mediator-Nucleosome Interaction" Mol. Cell, 6, 197 (2000).

Asturias, F. J.; Jiang, Y. W.; Myers, L. C.; Gustafsson, C. M.; Kornberg, R. D.; "Imaging of Yeast and Mammalian Mediator of Transcriptional Regulation and RNA Polymerase II Holoenzyme" Science 283, 985 (1999).

Gustafsson, C. M.; Myers, L. C.; Beve, J.; Spåhr, H.; Lui, M.; Erdjument-Bromage, H.; Tempst, P.; Kornberg, R. D.; "Identification of New Mediator Subunits in the RNA Polymerase II Holoenzyme from Saccharomyces cerevisiae" J. Biol. Chem. 273, 30851 (1998).

Myers, L. C. (*); Gustafsson, C. M. (*); Bushnell, D. A.; Lui, M.; Erdjument-Bromage, H.; Tempst, P.; Kornberg, R. D.; "The Med proteins of yeast and their function through the RNA polymerase II C-terminal domain" Genes & Dev. 12, 45 (1998). (*Equal Contribution). [PDF]

Gustafsson, C. M. (*); Myers, L. C. (*); Li, Y.; Redd, M. J.; Lui, M.; Erdjument-Bromage, H.; Tempst, P.; Kornberg, R. D.; "Identification of Rox3 as a Component of Mediator and RNA Polymerase II Holoenzyme" J. Biol. Chem. 272, 48 (1997). (*Equal Contribution).

Habazettl, J.; Myers, L. C.; Yuan, F.; Verdine, G. L.; Wagner, G. "Backbone Dynamics, Amide Hydrogen Exchange, and Resonance Assignments of the DNA Methylphosphotriester Repair Domain of Escherichia coli Ada" Biochemistry 35, 9335 (1996).

Myers, L. C.; Wagner, G.; Verdine, G. L. "Direct Activation of the Methyl Chemosensor Protein N-Ada by Methyl Iodide" J. Am. Chem. Soc. 117, 10750 (1995).

Myers, L. C.; Jackow, F.; Verdine, G. L. "Metal Dependence of Transcriptional Switching in Escherichia coli Ada" J. Biol. Chem. 270, 6664 (1995).

Myers, L. C.; Cushing, T. D.; Verdine, G. L. "Metal-Coordination Sphere in the Methylated Ada Protien/DNA Co-Complex" Chemistry & Biology 1, 91 (1994).

Myers, L. C.; Verdine, G. L.; Wagner, G. "Solution Structure of the DNA Methylphosphotriester Repair Domain of Escherichia coli Ada" Biochemistry 32, 14089 (1993).

Myers, L. C.; Terranova, M. P.; Ferentz, A. E.; Wagner, G.; Verdine, G. L. "Repair of DNA Methylphosphostriesters through a Metalloactivated Cysteine Nucleophile" Science 261, 1164 (1993).

Lee, S. A.; Myers, L. C.; Powell, J. W.; Suleski, T. J. ; Rupprecht, A. "Raman and Infrared Studies of Wet-Spun Films of Na-Hyaluronate," J. Biomol. Str. and Dynamics 11, 191 - 202 (1993).

Myers, L. C.; Terranova, M. P.; Nash, H. M.; Markus, M. A.; Verdine, G. L. "Zinc Binding by the Methylation Signaling Domain of Escherichia coli Ada Protein" Biochemistry 31, 4541 (1992).

Reviews and Invited Papers:

Myers, L. C.; Leuther, K.; Bushnell, D. A.; Gustafsson, C. M.; Kornberg, R. D.; "Yeast RNA Polymerase II Transcription with Purified Proteins" METHODS Comp. Meth. Enzymol. 272, 48 (1997).

Myers, L. C.; Verdine, G. L. "DNA Repair Proteins" Current Opinion in Structural Biology 4, 51 (1994).