Joshua W. Hamilton, Ph.D.
Director, Molecular Biology & Proteomincs Core Facility

E-mail: Joshua.W.Hamilton@Dartmouth.edu

Areas of Expertise: Molecular Toxicology

Research Topics/Working Groups: Molecular toxicology of metals/ group leader; Endocrine disruption; Molecular biomarkers; Epidemiology of arsenic; Epidemiology of environmental agents in children; Toxic Metals Research Program/Director
Research: Joshua Hamilton investigates how environmental chemicals, particularly toxic metals, affect biochemical processes in ways that might contribute to human disease. More specifically, he studies the preferential effects of the carcinogenic metals arsenic and chromium on gene expression at very low doses. He and his research group recently discovered that arsenic can act as an endocrine disrupting chemical, and they are now focused on whether these alterations in hormone-mediated pathways may contribute to the ability of arsenic to increase the risk of diabetes, vascular disease and certain cancers.