A full list of publications can be found on PubMed

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Selected Publications

A.N. Kettenbach, T. Wang, B.K. Faherty, D.R. Madden, S. Knapp, C. Bailey-Kellogg, S.A. Gerber (2012) Rapid determination of multiple linear kinase substrate motifs by mass spectrometry. Chem Biol. 19, 608-618.

K.E. Roberts, P.R. Cushing, P. Boisguerin, D.R. Madden, B.R. Donald (2012) Computational Design of a PDZ Domain Peptide Inhibitor that Rescues CFTR Activity. PLoS Comput Biol. 8, e1002477.

K.M. Cihil,P. Ellinger, A. Fellows, D.B. Stolz, D.R. Madden, A. Swiatecka-Urban (2012) Disabled-2 Protein Facilitates Assembly Polypeptide-2-independent Recruitment of Cystic Fibrosis Transmembrane Conductance Regulator to Endocytic Vesicles in Polarized Human Airway Epithelial Cells. J Biol Chem. 287, 15087-15099.

C.R. Midgett, A. Gill, D.R. Madden (2012) Domain architecture of a calcium-permeable AMPA receptor in a ligand-free conformation. Front Mol Neurosci. 4, 56.

C.D. Bahl, D.R. Madden (2012) Pseudomonas aeruginosa Cif defines a distinct class of α/β epoxide hydrolases utilizing a His/Tyr ring-opening pair. Protein Pept Lett. 19, 186-193.

W. Park, C.R. Midgett, D.R. Madden, G.S. Chirikjian (2011) A Stochastic Kinematic Model of Class Averaging in Single-Particle Electron Microscopy. Int J Rob Res. 30, 730-754.

J.F. Amacher, P.R. Cushing, J.A. Weiner, D.R. Madden (2011) Crystallization and preliminary diffraction analysis of the CAL PDZ domain in complex with a selective peptide inhibitor. Acta Crystallogr. F67, 600-603.

A. Gill, T.C. Scanlon, D.C. Osipovitch, D.R. Madden, K.E. Griswold (2011) Crystal structure of a charge engineered human lysozyme having enhanced bactericidal activity. PLoS One. 6, e16788.

M.V. Navarro, P.D. Newell, P.V. Krasteva, D. Chatterjee, D.R. Madden, G.A. O'Toole, H. Sondermann (2011) Structural basis for c-di-GMP-mediated inside-out signaling controlling periplasmic proteolysis. PLoS Biol. 9, e1000588.

P.R. Cushing, L. Vouilleme, M. Pellegrini, P. Boisguerin, D.R. Madden (2010) A Stabilizing Influence: CAL PDZ Inhibition Extends the Half-Life of ΔF508-CFTR. Angew Chem Int Ed Engl. 49, 9907-9911.

L. Vouilleme, P.R. Cushing, R. Volkmer, D.R. Madden, P. Boisguerin (2010) Engineering Peptide inhibitors to overcome PDZ binding promiscuity. Angew Chem Int Ed Engl. 49, 9912-9916.

W. Park, D.R. Madden, D.N. Rockmore, G.S. Chirikjian (2010) Deblurring of Class-Averaged Images in Single-Particle Electron Microscopy. Inverse Probl. 26, 3500521-35005229.

C.D. Bahl, C. Morisseau, J.M. Bomberger, B.A. Stanton, B.D. Hammock, G.A. O'Toole, D.R. Madden (2010) Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor. J Bacteriol. 192, 1785-1795.

A. Birdsey-Benson, A. Gill, L.P. Henderson, D.R. Madden (2010) Enhanced efficacy without further cleft closure: reevaluating twist as a source of agonist efficacy in AMPA receptors. J Neurosci. 30, 1463-1470.

C.D. Bahl, D.P. MacEachran, G.A. O'Toole, D.R. Madden. (2010) Purification, crystallization and preliminary X-ray diffraction analysis of Cif, a virulence factor secreted by Pseudomonas aeruginosa. Acta Crystallogr F66, 26-28.

N. Nayeem, Y. Zhang, D.K. Schweppe, D.R. Madden, T. Green (2009) A nondesensitizing kainate receptor point mutant. Mol Pharmacol. 76, 534-542.

A. Gill, A. Birdsey-Benson, B.L. Jones, L.P. Henderson, D.R. Madden (2008) Correlating AMPA receptor activation and cleft closure across subunits: crystal structures of the GluR4 ligand-binding domain in complex with full and partial agonists. Biochemistry, 47, 13831-13841.

A. Gill, D.R. Madden (2008) Purification and crystallization of a non-GluR2 AMPA-receptor ligand-binding domain: a case of cryo-incompatibility addressed by room-temperature data collection. Acta Crystallogr, F64, 831-835.

P.R. Cushing, A. Fellows, D. Villone, P. Boisguérin, D.R. Madden (2008) The relative binding affinities of PDZ partners for CFTR: a biochemical basis for efficient endocytic recycling. Biochemistry 47, 10084-10098.

C.R. Midgett, D.R. Madden (2008) The quaternary structure of a calcium-permeable AMPA receptor: conservation of shape and symmetry across functionally distinct subunit assemblies. J Mol Biol. 382, 578-584.

C.R. Midgett, D.R. Madden (2007) Breaking the bottleneck: eukaryotic membrane protein expression for high-resolution structural studies. J Struct. Biol., 160, 265-274.

D.R. Madden, M. Safferling (2007) Baculoviral expression of an integral membrane protein for structural studies. Methods Mol Biol. 363, 39-57.

M. Wolde, A. Fellows, J. Cheng, A. Kivenson, B. Coutermarsh, L. Talebian, K. Karlson, A. Piserchio, D.F. Mierke, B.A. Stanton, W.B. Guggino, D.R. Madden (2007) Targeting CAL as a negative regulator of ΔF508-CFTR cell-surface expression: an RNA interference and structure-based mutagenetic approach. J Biol Chem. 282, 8099-8109

D.R. Madden (2005) New light on an open-and-shut case. Nature Chem. Biol. 1, 317-319.

A. Piserchio, A. Fellows, D.R. Madden, and D.F. Mierke (2005) Association of the cystic fibrosis transmembrane conductance regulator with CAL: structural features and molecular dynamics. Biochemistry 44, 16158-16166.

J. Féthière, D. Venzke, D.R. Madden, and B. Böttcher (2005) Peripheral stator of the yeast V-ATPase: stoichiometry and specificity of interaction between the EG-complex and subunits C and H. Biochemistry 44, 15906-15914.

D.R. Madden, N. Armstrong, D. Svergun, J. Pérez and P. Vachette (2005) Solution X-ray scattering evidence for agonist- and antagonist-induced modulation of cleft closure in a glutamate receptor ligand-binding domain. J Biol Chem. 280, 23637-23642.

A. Gill and D.R. Madden (2005). Glutamate receptor ion channels: structural insights into molecular mechanisms. In The Structural Biology of Membrane Proteins (Buchanan, S, and Grisshammer, R, eds.), Cambridge, UK: Royal Society of Chemistry.

D.R. Madden, Q. Cheng, S. Thiran, S. Rajan, F. Rigo, K. Keinänen, S. Reinelt, H. Zimmermann and V. Jayaraman (2004) Stereochemistry of glutamate receptor agonist efficacy: engineering a dual-specificity AMPA/kainate receptor. Biochemistry 43, 15838-15844.

W. Tichelaar, M. Safferling, K. Keinänen, H. Stark and D.R. Madden (2004) The three-dimensional structure of an ionotropic glutamate receptor reveals a dimer-of-dimers assembly. J Mol Biol. 344, 435-442.

S. Reinelt, E. Hofmann, T. Gerharz, M. Bott and D.R. Madden (2003) The structure of the periplasmic ligand-binding domain of the sensor kinase CitA reveals the first extracellular PAS domain. J Biol Chem. 278, 39189-39196.

A. Pasternack, S.K. Coleman, J. Féthière, D.R. Madden, J.P. LeCaer, J. Rossier, M. Pasternack, K. Keinänen K. (2003) Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain. J Neurochem. 85, 1184-1192

D.R. Madden (2002) The inner workings of the AMPA receptors. Curr Opin Drug Discov Devel. 5, 741-748

D.R. Madden (2002) The structure and function of glutamate receptor ion channels. Nature Rev. Neurosci. 3, 91-101.

B. Klockow, W. Tichelaar, D.R. Madden, H.H. Niemann, T. Akiba, K. Hirose, D.J. Manstein (2002) The dynamin A ring complex: molecular organization and nucleotide-dependent conformational changes. EMBO J. 21, 240-250.

M. Safferling, W. Tichelaar, G. Kümmerle, A. Jouppila, A. Kuusinen, K. Keinänen and D.R. Madden (2001) First images of a glutamate receptor ion channel: oligomeric state and molecular dimensions of GluRB homomers. Biochemistry, 40, 13948-13953.

D.R. Madden, S. Thiran, H. Zimmermann, J. Romm and V. Jayaraman (2001) Stereochemistry of quinoxaline antagonist binding to a glutamate receptor investigated by Fourier transform infrared spectroscopy. J Biol Chem., 276, 37821-37826.

J. Féthière, A. Andersson, K. Keinänen and D.R. Madden (2000) Crystallization of an AMPA receptor binding domain without agonist: importance of carbohydrate content and crystal freezing conditions. Acta Cryst., D56, 1625-1629.

V. Jayaraman, R. Keesey, D.R. Madden (2000) Ligand--protein interactions in the glutamate receptor. Biochemistry, 39, 8693-8697.

V. Jayaraman, S. Thiran, D.R. Madden (2000) Fourier transform infrared spectroscopic characterization of a photolabile precursor of glutamate. FEBS Lett., 475, 278-282.

D.R. Madden, R. Abele, A. Andersson, K. Keinänen (2000) Large-scale expression and thermodynamic characterization of a glutamate receptor agonist-binding domain. Eur J Biochem., 267, 4281-4289.

R. Abele, K. Keinänen and D.R. Madden (2000) Agonist-induced isomerization in a glutamate receptor ligand-binding domain: a kinetic and mutagenetic analysis. J Biol Chem. 275, 21355-21363.

A. Kuusinen, R. Abele, D.R. Madden, K. Keinänen (1999) Oligomerization and ligand-binding properties of the ectodomain of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunit GluRD. J Biol Chem. 274, 28937-28943.

R. Abele, D. Svergun, K. Keinänen, M.H. Koch, D.R. Madden (1999) A molecular envelope of the ligand-binding domain of a glutamate receptor in the presence and absence of agonist. Biochemistry, 38, 10949-10957.

R. Abele, M. Lampinen, K. Keinänen, D.R. Madden, (1998) Disulfide bonding and cysteine accessibility in the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit GluRD. Implications for redox modulation of glutamate receptors. J Biol Chem. 273, 25132-25138.