Selected Publications:
R. Abele, K. Keinänen and D.R. Madden (2000) Agonist-induced isomerization in a glutamate receptor ligand-binding domain: a kinetic and mutagenetic analysis. J. Biol. Chem. 275, 21355-21363.
J. Féthière, A. Andersson, K. Keinänen and D.R. Madden (2000) Crystallization of an AMPA receptor binding domain without agonist: importance of carbohydrate content and crystal freezing conditions. Acta Cryst., D56, 1625-1629.
D.R. Madden, S. Thiran, H. Zimmermann, J. Romm and V. Jayaraman (2001) Stereochemistry of quinoxaline antagonist binding to a glutamate receptor investigated by Fourier transform infrared spectroscopy. J. Biol. Chem., 276, 37821-37826.
M. Safferling, W. Tichelaar, G Kümmerle, A. Jouppila, A. Kuusinen, K. Keinänen and D.R. Madden (2001) First images of a glutamate receptor ion channel: oligomeric state and molecular dimensions of GluRB homomers. Biochemistry, 40, 13948-13953.
D.R. Madden (2002) The structure and function of glutamate receptor ion channels. Nature Rev. Neurosci. 3, 91-101.
S. Reinelt, E. Hofmann, T. Gerharz, M. Bott and D.R. Madden (2003) The structure of the periplasmic ligand-binding domain of the sensor kinase CitA reveals the first extracellular PAS domain. J. Biol. Chem. 278, 39189-39196.W. Tichelaar, M. Safferling, K. Keinänen, H. Stark and D.R. Madden (2004) The three-dimensional structure of an ionotropic glutamate receptor reveals a dimer-of-dimers assembly. J. Mol. Biol. 344, 435-442.
D.R. Madden, Q. Cheng, S. Thiran, S. Rajan, F. Rigo, K. Keinänen, S. Reinelt, H. Zimmermann and V. Jayaraman (2004) The stereochemistry of glutamate receptor agonist efficacy: engineering a dual-specificity AMPA/kainate receptor. Biochemistry 43, 15838-15844.
D.R. Madden, N. Armstrong, D. Svergun, J. Pérez and P. Vachette (2005) Solution X-ray scattering evidence for agonist- and antagonist-induced modulation of cleft closure in a glutamate receptor ligand-binding domain. J. Biol. Chem. 280, 23637-23642.
Madden, DR. (2005) New light on an open-and-shut case. Nature Chem. Biol. 1, 317-319.
J. Féthière, D. Venzke, D.R. Madden, and B. Böttcher (2005) The peripheral stator of the yeast V-ATPase: stoichiometry and specificity of interaction between the EG-complex and subunits C and H. Biochemistry 44, 15906-15914.
A. Piserchio, A. Fellows, D.R. Madden, and D.F. Mierke (2005) Association of the cystic fibrosis transmembrane conductance regulator with CAL: structural features and molecular dynamics. Biochemistry 44, 16158-16166.
A. Gill and D.R. Madden (2005). Glutamate receptor ion channels: structural insights into molecular mechanisms. In The Structural Biology of Membrane Proteins (Buchanan, S, and Grisshammer, R, eds.), Cambridge, UK: Royal Society of Chemistry, in press.
D.R. Madden and M. Safferling (2005) Baculoviral expression of an integral membrane protein for structural studies. Methods Mol. Biol., in press.
Last Update: December 12, 2005