COBRE Lung Biology Projects
The Dartmouth Lung Biology Center consists of four projects.
Project 1
Molecular Mechanisms of Aurora Kinase A Dysfunction in Lung Cancer
Junior Investigator and Project Leader:
Scott A. Gerber, Ph.D.
Assistant Professor of Genetics
Geisel School of Medicine at Dartmouth
Project 2
A Novel Regulator of P. aeruginosa Virulence Genes
Junior Investigator and Project Leader:
Deborah A. Hogan, Ph.D.
Associate Professor, Microbiology and Immunology
Geisel School of Medicine at Dartmouth
Project 3
Humanizing Alginate Depolymerase: New Strategies for De-immunizing Enzyme Therapies
Junior Investigator and Project Leader:
Karl E. Griswold, Ph.D.
Assistant Professor
Thayer School of Engineering
Geisel School of Medicine at Dartmouth
Project 4
Biodiesel and Petroleum Diesel: Exposure Profiles and Public Health Consequences
Junior Investigator and Project Leader:
Nora Traviss, Ph.D.
Assistant Professor, Environmental Studies
School of Sciences and Social Sciences
Keene State College
The Center also funds nine pilot and feasibility projects, with support from the COBRE, the Cystic Fibrosis Foundation, and the Hitchcock Foundation:
P&F Project 1 - Microbiome of the CF Lung: Impact of Iron and Antibiotics
Principal Investigator: George O'Toole, Ph.D.
P&F Project 2 - Damaging Effects of Bacterial-fungal Co-infection of the Lung Principal Investigator: Deborah Hogan, Ph.D.
P&F Project 3 - Iron Chelation Therapy with Lactoferrin
Principal Investigator: Bruce Stanton, Ph.D.
P&F Project 4 - Development of CAL Inhibitors for CFTR Functional Rescue
Principal Investigator: Dean Madden, Ph.D.
P&F Project 5 - Anti-Pseudomonal Synergy of Engineered Lysozymes and Orthogonal Antibiotics
Principal Investigator: Karl Griswold, Ph.D.
P&F Project 6 - Phagocytic Mechanisms of Pseudomonas Clearance within the CF lung
Principal Investigator: Brent Berwin, Ph.D., Assistant Professor of Microbiology and Immunology
P&F Project 7 - Evaluation of Iron-Related Hematologic Parameters in Adult Patients with Cystic Fibrosis
Principal Investigators: Dr. Worth Parker, Associate Professor of Medicine and Dr. Alex Gifford, Assistant Professor of Medicine
P&F Project 8 - The Developing Infant with Cystic Fibrosis: Mapping the Microbiome in Health and Disease
Principal Investigator: Juliette Madan, M.D
P&F Project 9 - Impact of Antibiotics on the CF Microbiome
Principal Investigator: George O'Toole, Ph.D.
