Lung Biology Center Pilot Projects

Funded by an NIH IDeA Program COBRE and by a Cystic Fibrosis Foundation Research Development Program


Dab2 Inhibitors as therapeutic stabilizers of F508-CFTR

Project Leader: Dean Madden, Ph.D.

Microbiological profiles in sputum and in regions of airway damage

Project Leader: Alix Ashare, M.D., Ph.D.
Co-Investigator: Deborah A. Hogan, Ph.D.

Arsenic exposure and airway remodeling after acute influenza infection

Project Leader: Mitsuo Matsuoka, MD, Ph.D.
Co-Investigator: Richard I. Enelow, M.D.

Optimization of a novel compound with activity against MRSA and P. aeruginosa

Project Leader: Ambrose Cheung, M.D.

Development of cFLIP-calmodulin interaction inhibitors for lung cancer therapy

Project Leader: Maria Pellegrini, Ph.D.
Co-Investigator: Dale F. Mierke, Ph.D.

Fungal Metabolic Adaptation and Inflammatory Lung Disease

Project Leader: Robert A Cramer, Ph.D.

Reconstitution of Microbial Communities of CF Infants

Project Leader and Investigator: George A O'Toole, Ph.D.

Analysis and Evasion of Pathogen-derived Lysozyme Inhibitors

Project Leader: Karl E. Griswold, Ph.D.
Co-Investigator: Brent Berwin, Ph.D.

Novel molecular methods for the analysis of cystic fibrosis (CF) sputum

Project Leader: Joseph Schwartzman, M.D.

The longitudinal microbiology and immunology of the airway in mechanically ventilated adults

Project Leader: Manuel Vilchez, M.D.
Co-Investigators: Richard Zuckerman, M.D., M.P.H., Harold Manning, M.D., George A O'Toole, Ph.D.