Recent News

APRIL

Lung Biology Center 2015 Pilot Awards

The Dartmouth Lung Biology Center requests applications for Pilot Project Program (P^3) Awards. We seek to fund basic, translational, and clinical research that will advance the understanding and treatment of lung disease, strengthen interdisciplinary faculty interactions, and leverage extramural funding opportunities. Deadline: April 27, 2015. For details, please see RFA announcement.

Researchers Jane Hill & Alix Ashare Receive SYNERGY Pilot Award

Researchers Jane E. Hill, PhD (PI, Engineering/Thayer) and Alix Ashare, MD, PhD (Co-PI, Medicine) recently received a SYNERGY Translational Pilot Award for the project “Biomarker Discovery and Validation for Lung Infection in CF patients”. Their project was one of eight awards made out of a total of 24 full applications that were submitted. For additional information, please see Geisel Insider.

Laura Filkins Accepted Into Postdoctoral Fellowship

Laura Filkins, a Ph.D. student in the O'Toole Lab, has been accepted into a very competitive Medical Microbiology fellowship at the Department of Pathology, University of Utah School of Medicine and ARUP Laboratories. Please see O'Toole Lab News for additional information.

O'Toole Lab Findings on Airway Health

In a recent collaborative study with collegaues at Dartmouth, led by Juliette Madan (in the Dept. of Pediatrics) and Annie Hoen (in the Dept. of Epidemiology), the O'Toole Lab investigated the upper airway and gut microflora of infants and children with CF. This group of children ranged up to almost 3 years of age. In this report, the research team demonstrates a link between the microflora in the gut and respiratory health. In particular, the researchers show an association between gut microbiota and initial Pseudomonas aeruginosa colonization and onset of exacerbation. This exciting finding suggests that oral probiotics have the potential to impact airway health. The paper recently was published online in the Journal of Pediatrics.

MARCH

3rd Annual Cystic Fibrosis Retreat Held at Geisel School of Medicine

Over 100 Cystic Fibrosis (CF) researchers from New England attended the 3rd annual Cystic Fibrosis Retreat at the Geisel School of Medicine at Dartmouth College on March 10, 2015. Twelve invited speakers presented a variety of talks on CF drug discovery, bacterial infections and inflammation in CF.

FEBRUARY

Karl Griswold Group Publishes Articles on Antibacterial Enzymes

Karl Griswold and his students recently published a series of articles on developmental antibacterial enzymes. These articles describe two advances: 1. Designing human lysozyme variants that evade inhibitory proteins produced by bacterial pathogens. 2. Engineering S. aureus's own cell wall recycling machinery so as to render these endogenous enzymes potent antibacterial agents.

Links to the three articles:

Click here to read article.
Click here to read article.
Click here to read article.

Laura Filkins Receives Travel Grant, Presents Poster

Laura Filkins, a PhD student in the O'Toole lab, received a $500 travel grant for the ASM Conference on Polymicrobial Infections. Laura presented a poster at the meeting titled "Dynamic P. aeruginosa-S. aureus inter-bacterial interactions impact community composition and s. aureus survival in the respiratory tract of patients with cystic fibrosis".

Small Fish Provide Major Insight into How Organisms Adapt to Change

A team of scientists that includes Lung Biology Center investigators Bruce Stanton and Thomas Hampton have identified the genes and regulatory networks that enable organisms to alter themselves physically in response to changes in their environment. The paper was published in the journal Molecular Biology and Evolution and was named one of the “papers of the month” by the National Institute of Environmental Health Sciences. See full story.

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Events

8th Annual Integrative Biology Symposium: "Epigenetics"

April 21-22, 2015

This symposium on epigenetics will explore how environmental factors affect gene expression and the characteristics of organisms. Click here for more information.

Cystic Fibrosis Foundation Great Strides Walk

Date: May 2, 2015

The Dartmouth Lung Biology Center is walking as Team Dartmouth Lung Biology in the Hanover Great Strides walk on May 2, 2015. The Hanover Great Strides Walk is a 5k trail walk at the beautiful Storrs Pond Recreation Area. Registration is at 10:00am. The walk begins at 10:30am. Great Strides walks are the largest fundraisers organized by the Cystic Fibrosis Foundation. Money raised will go towards research on treatment and cures for CF. Click here to join or contribute to Team Dartmouth Lung Biology. To create your own team click here.

Introduction to Applied Bioinformatics Course at MDIBL

August 1-6, 2015

The goal of the Applied Bioinformatics Course is to provide hands-on training with major bioinformatics resources while developing a conceptual framework to foster successful application of the bioinformatic skillset to biological research. We will focus on analysis of high throughput sequencing data to identify differentially expressed genes, investigate biological functions, and predict interaction networks. Topics covered include web-based gene and protein resources, genome browsers, DNA and RNA-Seq data analysis using CLC Genomics Workbench and the R statistical computing environment, Ingenuity® pathway analysis, gene set enrichment analyses and machine learning applications.

More information can be found at the course web site.