Researcher Alex Gifford Publishes Paper on Updated Survival Projection for CF Patients
The paper Longevity of Patients with Cystic Fibrosis in 2000 to 2010 and Beyond: Survival Analysis of the Cystic Fibrosis Foundation Patient Registry was based on data in the U.S. Cystic Fibrosis Foundation Patient Registry. It was published last fall in the Annals of Internal Medicine.
Researchers Jane Hill & Alix Ashare Receive SYNERGY Pilot Award
Researchers Jane E. Hill, PhD (PI, Engineering/Thayer) and Alix Ashare, MD, PhD (Co-PI, Medicine) recently received a SYNERGY Translational Pilot Award for the project Biomarker Discovery and Validation for Lung Infection in CF patients. Their project was one of eight awards made out of a total of 24 full applications that were submitted. For additional information, please see Geisel Insider.
Laura Filkins Accepted Into Postdoctoral Fellowship
Laura Filkins, a Ph.D. student in the O'Toole Lab, has been accepted into a very competitive Medical Microbiology fellowship at the Department of Pathology, University of Utah School of Medicine and ARUP Laboratories. Please see O'Toole Lab News for additional information.
8th Annual Integrative Biology Symposium on "Epigenetics" Held at Dartmouth College
The April 21-22 symposium on epigenetics explored how environmental factors affect gene expression and the characteristics of organisms. Click here for the agenda.
O'Toole Lab Findings on Airway Health
In a recent collaborative study with collegaues at Dartmouth, led by Juliette Madan (in the Dept. of Pediatrics) and Annie Hoen (in the Dept. of Epidemiology), the O'Toole Lab investigated the upper airway and gut microflora of infants and children with CF. This group of children ranged up to almost 3 years of age. In this report, the research team demonstrates a link between the microflora in the gut and respiratory health. In particular, the researchers show an association between gut microbiota and initial Pseudomonas aeruginosa colonization and onset of exacerbation. This exciting finding suggests that oral probiotics have the potential to impact airway health. The paper recently was published online in the Journal of Pediatrics.
Lung Biology Center 2015 Pilot Awards
The Dartmouth Lung Biology Center requests applications for Pilot Project Program (P^3) Awards. We seek to fund basic, translational, and clinical research that will advance the understanding and treatment of lung disease, strengthen interdisciplinary faculty interactions, and leverage extramural funding opportunities. Deadline: April 27, 2015. For details, please see RFA announcement.
3rd Annual Cystic Fibrosis Retreat Held at Geisel School of Medicine
Over 100 Cystic Fibrosis (CF) researchers from New England attended the 3rd annual Cystic Fibrosis Retreat at the Geisel School of Medicine at Dartmouth College on March 10, 2015. Twelve invited speakers presented a variety of talks on CF drug discovery, bacterial infections and inflammation in CF.
Karl Griswold Group Publishes Articles on Antibacterial Enzymes
Karl Griswold and his students recently published a series of articles on developmental antibacterial enzymes. These articles describe two advances: 1. Designing human lysozyme variants that evade inhibitory proteins produced by bacterial pathogens. 2. Engineering S. aureus's own cell wall recycling machinery so as to render these endogenous enzymes potent antibacterial agents.
Links to the three articles:
Laura Filkins Receives Travel Grant, Presents Poster
Laura Filkins, a PhD student in the O'Toole lab, received a $500 travel grant for the ASM Conference on Polymicrobial Infections. Laura presented a poster at the meeting titled "Dynamic P. aeruginosa-S. aureus inter-bacterial interactions impact community composition and s. aureus survival in the respiratory tract of patients with cystic fibrosis".
Small Fish Provide Major Insight into How Organisms Adapt to Change
A team of scientists that includes Lung Biology Center investigators Bruce Stanton and Thomas Hampton have identified the genes and regulatory networks that enable organisms to alter themselves physically in response to changes in their environment. The paper was published in the journal Molecular Biology and Evolution and was named one of the papers of the month by the National Institute of Environmental Health Sciences. See full story.