2016 News

APRIL

Literature Review Published by Dr. Juliette Madan

Dr. Juliette Madan, Division of Pediatrics, Geisel School of Medicine at Dartmouth, has published a literature review, "Neonatal gastrointestinal and respiratory microbiome in cystic fibrosis: potential interactions and implications for systemic health". Click here for link to the article. The review also was highlighted on the MDLinx website.

MARCH

6th Annual Cystic Fibrosis Retreat Held at Dartmouth

The 6th annual Dartmouth Cystic Fibrosis Retreat was held on March 22 at the Hanover Inn in Hanover, NH. More than 100 people attended. The goal of the retreat is to bring together basic- and physician-scientists with clinicians and with members of pharma and biotech to talk about all aspects of science and care related to CF. This is a regional meeting drawing investigators from across New England. The Dartmouth CF retreat was generously sponsored by Vertex Pharmaceuticals.

Lung Biology Center 2016 Pilot Awards

The Dartmouth Lung Biology Center requests applications for Pilot Project Program (P^3) Awards. We seek to fund basic, translational, and clinical research that will advance the understanding and treatment of lung disease, strengthen interdisciplinary faculty interactions, and leverage extramural funding opportunities. Deadline: April 8, 2016. For details, please see the RFA 2016 announcement.

JANUARY

$15 Million Gift to the Dartmouth Cystic Fibrosis Research Program

A generous donor has given $15 million to the Dartmouth CF Research Program to increase Dartmouth's expertise in systems biology, bioinformatics, and microbial pathogenesis in CF. According to Bruce A. Stanton, Ph.D., Director of the CF Research Program at Dartmouth, "This magnanimous gift to our CF Research Program will strengthen, intensify and expand our research efforts to identify personalized cures for every CF patient. The generosity of this donor will benefit generations and generations of people who live with CF every day.” With this gift, Dartmouth has the opportunity to take CF research and treatment to levels undreamed of even a decade ago. Because the disease is unique for each patient, there is a growing emphasis on developing innovative, personalized treatments. Dartmouth will create a research program with the ambitious goal of developing novel therapeutics for all cystic fibrosis patients and eliminating fungal and bacterial lung infections. For more information on the gift, see coverage in Dartmouth Now and the Geisel News Center.

New Machine-Learning Technique Can be Applied to Study of Pseudomonas aeruginosa

There are now vast quantities of data that are uploaded and made available but rarely used. A collaboration between Deborah Hogan, Associate Professor in Microbiology and Immunology and Dartmouth Lung Biology Center Researcher and Casey Greene, Assistant Professor at the University of Pennsylvania and a former Dartmouth Lung Biology Center Researcher, developed a method to make these data useful to researchers. Their application of this method to the study of Pseudomonas aeruginosa, a major challenge for individuals with Cystic Fibrosis, has been published in the journal mSystems. For more information, see Penn Medicine News Release and the paper ADAGE-Based Integration of Publicly Available Pseudomonas aeruginosa Gene Expression Data with Denoising Autoencoders Illuminates Microbe-Host Interactions.

A Microbiome is Borne - Science Friday

"A baby in the womb is protected from most microorganisms. But when that baby enters the outside world, it's greeted by a welcoming committee of bacteria. Now, researchers are trying to sort out what effect factors like an infant's delivery method and early diet have on its community of microorganisms. Juliette Madan and Anne Hoen, two authors of a paper published recently in the journal JAMA Pediatrics, say that developing a better understanding of the infant microbiome could one day lead to healthier babies." Click here for more information on "A Microbiome is Born".

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