COBRE Center for Lung Biology Research

Lung disease is the third most frequent cause of death in this country, claiming ~360,000 Americans annually. Tragically, an additional 25 million live with chronic lung diseases, including asthma, emphysema, cancer and cystic fibrosis. Unfortunately, the number of individuals with lung disease is increasing at an alarming rate, thus, a better understanding of the etiology of lung disease and new therapeutics to treat lung disease are required.

The goals of the Dartmouth Lung Biology Center, funded by a COBRE award by the NCRR and NIGMS since 2003 (P20-RR018787/GM103413 and P30-GM106394), are to enhance the research efforts of our faculty and students by:

  1. Integration of the COBRE supported Cores (Host Pathogen Integration Core, Live Cell Imaging Core, and Translational Research Core) with shared services in the Geisel School of Medicine at Dartmouth, Dartmouth Hitchcock Medical Center(DHMC) and other IDeA supported Cores, including Bioinformatics and Biostatistics;

  2. Fostering synergistic scientific collaboration through the COBRE Research Projects, associated Cores, and other basic and translational infrastructure and programs at the Geisel School of Medicine at Dartmouth/DHMC, including the Immunology COBRE, the Bioinformatics COBRE, the Center for Epidemiology COBRE, and the Dartmouth INBRE programs;

  3. Mentoring and supporting the career development of all faculty in the program, and;

  4. Providing administrative support.

Pilot Projects:

Dab2 Inhibitors as Therapeutic Stabilizers of F508-CFTR

Project Leader: Dean Madden, Ph.D.

Microbiological profiles in sputum and in regions of airway damage

Project Leader: Alix Ashare, M.D., Ph.D.
Co-Investigator: Deborah A. Hogan, Ph.D.

Arsenic exposure and airway remodeling after acute influenza infection

Project Leader: Mitsuo Matsuoka, MD, Ph.D.
Co-Investigator: Richard I. Enelow, M.D.

Optimization of a novel compound with activity against MRSA and P. aeruginosa

Project Leader: Ambrose Cheung, M.D.

Development of cFLIP-calmodulin interaction inhibitors for lung cancer therapy

Project Leader: Maria Pellegrini, Ph.D.
Co-Investigator: Dale F. Mierke, Ph.D.

Fungal Metabolic Adaptation and Inflammatory Lung Disease

Project Leader: Robert A Cramer, Ph.D.

Reconstitution of Microbial Communities of CF Infants

Project Leader and Investigator: George A O'Toole, Ph.D.

Analysis and Evasion of Pathogen-derived Lysozyme Inhibitors

Project Leader: Karl E. Griswold, Ph.D.
Co-Investigator: Brent Berwin, Ph.D.

Novel molecular methods for the analysis of cystic fibrosis (CF) sputum

Project Leader: Joseph Schwartzman, M.D.

The longitudinal microbiology and immunology of the airway in mechanically ventilated adults

Project Leader: Manuel Vilchez, M.D.
Co-Investigators: Richard Zuckerman, M.D., M.P.H., Harold Manning, M.D., George A O'Toole, Ph.D.


Ashare named 2014 Asthma Foundation Scholar

May 23, 2014

Dr. Ali Ashare has been named a 2014 American Asthma Foundation Scholar. This prestigious award provides three years of funding for high risk translational research studies involving asthma. Her project entitled "Mechanisms of Increased Asthma Severity secondary to Polymorphisms in the ACE Gene" will investigate the mechanism by which a specific polymorphism in the human angiotensin converting enzyme (ACE) gene causes more severe asthmatic lung disease.

Walk Raises $17,000 for CF Research

May 17, 2014

On Saturday, May 17th, fifty-five walkers and runners, including Dartmouth researchers, clinicians and CF families, participated in the Cystic Fibrosis Foundation Great Strides Walk at Storrs Pond in Hanover. Great Strides is the CF Foundation's largest nationwide fund raising event and this year the Hanover walk raised over $17,000 for CF research and drug development! Walkers enjoyed snacks from Panera Bread, Woodstock Cookies and Moe's before and after a 3 mile trek through the Storrs Pond hiking trails. Lebanon, NH native Robert Plante was named honorary chair of the walk in recognition of his incredible fundraising efforts for CF research. Over the past 25 years, Robert has raised $250,000 in honor of his childhood friend who had CF. The Hanover Great Strides walk was organized by Deb Hogan, Katie Price, Kelli Hvorecny, Sharon Littlefield and Lindsay Gilbert.

2014 Pilot Awards

April 2, 2014

The Dartmouth Lung Biology Center requests applications for Pilot Project Program (P^3) Awards. We seek to fund basic, translational, and clinical research that will advance the understanding and treatment of lung disease, strengthen interdisciplinary faculty interactions, and leverage extramural funding opportunities. For details, please see the RFA announcement. The deadline is April 23, 2014.


Introduction to Applied Bioinformatics Course at MDIBL

October 9-14, 2014

The goal of the Applied Bioinformatics Course is to provide hands-on training with major bioinformatics resources while developing a conceptual framework to foster successful application of the bioinformatic skillset to biological research. We will focus on analysis of high throughput sequencing data to identify differentially expressed genes, investigate biological functions, and predict interaction networks. Topics covered include web-based gene and protein resources, genome browsers, DNA and RNA-Seq data analysis using CLC Genomics Workbench and the R statistical computing environment, Ingenuity® pathway analysis, gene set enrichment analyses and machine learning applications.

More information and the current agenda can be found at the course web site. Limited financial aid is available.