Bruce A. Stanton, Ph.D.
Professor of Microbiology and Immunology and of Physiology
Andrew C. Vail Professor
Remsen, Room 615
Dartmouth Medical School
Hanover, NH 03755-3836
Areas of Expertise: Cell biology of Cystic fibrosis, host pathogen interactions
Research: There are four major research programs in the Stanton laboratory: (1) Integrative genomics and proteomics of cystic fibrosis. The goal of this project is to utilize genomic and proteomic approaches to elucidate the CFTR interactome and to elucidate the cellular and molecular mechanisms whereby these interacting proteins regulate CFTR function and trafficking; (2) Host-pathogen interactions in Cystic Fibrosis. The goal of this project is to elucidate how Pseudomonas aeruginosa infects airway epithelial cells and forms drug resistant biofilms in patients with CF, and to understand how airway epithelial cells facilitate drug resistant by Pseudomonas aeruginosa using genomic and proteomic approaches; (3) CF drug discovery. In collaboration with several biotechnology companies the Stanton laboratory is developing new therapeutics approaches to treat and cure CF and (4) Arsenic and the ubiquitin - lysosomal pathway. The goal of this project is to elucidate how very low levels of environmental toxicants, primarily arsenic, affect lung function and human health using genomic, proteomic and physiological approaches to elucidate the cellular mechanisms whereby arsenic adversely affects physiological systems, and to assess the relevance of these observations to human health.