COBRE Center for Lung Biology Research

Lung disease is the third most frequent cause of death in this country, claiming ~360,000 Americans annually. Tragically, an additional 25 million live with chronic lung diseases, including asthma, emphysema, cancer and cystic fibrosis. Unfortunately, the number of individuals with lung disease is increasing at an alarming rate, thus, a better understanding of the etiology of lung disease and new therapeutics to treat lung disease are required.

The goals of the Dartmouth Lung Biology Center, funded by a COBRE award by the NCRR and NIGMS since 2003 (P20-RR018787/GM103413 and P30-GM106394), and funding from the CF Research Development Program (CFRDP) are to enhance the research efforts of our faculty and students by:

  1. Integration of the COBRE supported Cores (Host Pathogen Integration Core, Live Cell Imaging Core, and Translational Research Core) with shared services in the Geisel School of Medicine at Dartmouth, Dartmouth Hitchcock Medical Center(DHMC) and other IDeA supported Cores, including Bioinformatics and Biostatistics;

  2. Fostering synergistic scientific collaboration through the COBRE Research Projects, associated Cores, and other basic and translational infrastructure and programs at the Geisel School of Medicine at Dartmouth/DHMC, including the Immunology COBRE, the Bioinformatics COBRE, the Center for Epidemiology COBRE, and the Dartmouth INBRE programs;

  3. Mentoring and supporting the career development of all faculty in the program, and;

  4. Providing administrative support.

Pilot Projects:

Systems-Level Analysis of P. aeruginosa Response to Antibiotics with ADAGE

Project Leader: Deborah A. Hogan, Ph.D.

Respiratory Virus Infection and Pseudomonas Virulence in Cystic Fibrosis

Project Leader: Richard I. Enelow, M.D.
Co-Investigator: Peter Wright, M.D.

Mechanisms of Regional Heterogeneity of Lung Macrophage Inflammation

Project Leader: Alix Ashare, M.D., Ph.D.

Development of cFLIP-Calmodulin Interaction Inhibitors for Lung Cancer Therapy

Project Leader: Maria Pellegrini, Ph.D.
Co-Investigator: Dale F. Mierke, Ph.D.

Microbial Activity as a Determinant of Health Status in Cystic Fibrosis

Project Leader: Alex H. Gifford, M.D.

Promoting the Phagocytic Clearance of Non-Motile P. Aeruginosa

Project Leader: Brent Berwin, Ph.D.
Co-Investigator: Scott Gerber, Ph.D.

A Novel Murine Model of Allergic Bronchopulmonary Aspergillosis

Project Leader: Robert A. Cramer, Ph.D.
Co-Investigator: Joshua J. Obar, Ph.D.

Monitoring Efforts to Clear P. aeruginosain Cystic Fibrosis Patients

Project Leader: Jane Hill, Ph.D.

Linking Disease Outcomes to the Gut Microbiota in Infants and Children with CF

Project Leader: Todd A. MacKenzie, Ph.D.
Co-Investigators: Juliette Madan, M.D., M.S.; George A. O'Toole, Ph.D

News

2017

Victoria Holden Featured in Recent Video

June 2017

Victoria (Tori) Holden, a postdoctoral fellow in Lung Biology Center Director Bruce Stanton's lab, was highlighted in a video advertising ASM Microbe as a rising star in the field of Host-Microbe Biology. Check it out (0:53 into the video).

Director Stanton Authors Newly Released Physiology Textbook

May 2017

Lung Biology Center Director Bruce Stanton co-authored the 7th edition of the Berne and Levy Physiology textbook released this month. The textbook includes integrated coverage of all organ systems in the human body, key experimental observations and examples, and full-color design and artwork.

Article Among 50 Most Downloaded PLoS Pathogens Papers

May 2017

The paper, A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles, was among the top 50 most downloaded PLoS Pathogens papers. The article was written by Lung Biology Center researchers Drs. Deb Hogan, Bruce Stanton and Katja Koeppen and others from the Geisel School of Medicine at Dartmouth and the Norris Cotton Cancer Center.

Lung Biology Center 2017 Pilot Project Program Awards

May 2017

The Lung Biology Center requests applications for Pilot Project Program Awards that advance the understanding and treatment of Cystic Fibrosis, CF-related problems in other organ systems, or new treatments and therapies for improving or restoring CFTR function. The selected pilot project proposals will be submitted as a component of a P30 application focusing on all aspects of CF-related research.

Please see the RFA for details- these pilot applications are 1-2 paragraphs plus a CV. Applications are due May 31, 2017. If you have any question, don't hesitate to contact georgeo@dartmouth.edu.

Great Strides Walk Raises Over $20,000 for CF Research

May 2017

Jessie Scott and Katie Price, a current and a former trainee at Dartmouth, respectively, were two of the lead organizers for the Hanover Cystic Fibrosis Great Strides walk fundraiser on May 13 at the Storrs Pond Recreation Area. There were six teams total participating including: the Lung Biology Center at Dartmouth, Dartmouth-Hitchcock Medical Center and two family teams. Together, the teams raised over $20K for CF research!

Kickoff Event Held for May 13 Great Strides Walk

March 2017

A Cystic Fibrosis Lung Biology Team kick off event was held on March 24 for the Great Strides Walk for Cystic Fibrosis. The event had a great turnout of graduate students, post docs, and professors who work on CF. Everyone illustrated their research projects on a poster to be displayed at the May 13 Hanover Great Strides for Cystic Fibrosis Walk. To register for the Great Strides Walk and for additional information.

Annual CF Retreat Held on March 23

March 2017

The 6th annual Dartmouth Cystic Fibrosis Retreat was held on March 23 at the Hanover Inn in Hanover, NH. The goal is to bring together basic- and physician-scientists with clinicians and with members of pharma and biotech to talk about all aspects of science and care related to CF. More than 100 people attended from across New England. Talks spanned topics from host-pathogen interactions to immune responses in CF, to new therapies and clinical trial data, to clinical care and mining the CF registry. The Dartmouth CF Retreat was generously sponsored by Vertex Pharmaceuticals.

More News...

Events

2016-2017 Weekly Lung Biology Seminar Series Sponsored by Lung Biology Center

Please click here to view the weekly schedule.

2017 Applied Bioinformatics Course at MDI Biological Laboratory

Applied Bioinformatics Course 2017 will be held on July 15-20 at the MDI Biological Laboratory in Bar Harbor, ME. Applied Bioinformatics is a hands-on course for advanced graduate students, post-doctoral trainees, and researchers at all levels interested in incorporating bioinformatics into their research.

The Course's goal is to provide hands-on training on major bioinformatics resources through the analysis of a RNA-Seq data set to find differentially expressed genes and investigate previously described functions of those genes and the pathways in which they are involved.

Topics include web-based gene and protein resources, genome browsers, pathways and gene set enrichment analyses, and RNA-Seq data analysis. RNA-Seq data analysis will be conducted using CLC Genomics Workbench, the web-based Galaxy system, R statistical computing environment and Ingenuity Pathways Analysis. The course will feature several modules that will have examples to demonstrate how to apply the major tools or resources featured in the module. Participants should have a strong background in molecular biology. Prior computer programming skills are not required, but participants need to have a strong interest in learning some programming concepts. For more information and to register.