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George Langford, Ph.D.
Ernest Everett Just Professor of Natural Sciences, Professor of Biological Sciences, Adjunct Professor of Physiology Dartmouth College
Investigator, MBL, Woods Hole, MA

Vesicular Transport, Myosin Motors

Ph.D., Illinois Institute of Technology - 1971

Postdoc, U. Penn - 1971-1973

George Langford

(603) 646-3846

Dartmouth College Biological Sciences

Last Modified: 10th October 1999
Inquiries to: Dr. George Langford

Langford, G. M. and Inoue, S. (1979) Motility of the microtubular axostyle in Pyrsonympha. J. Cell Biol. 80:521-538.

Langford, G.M. (1980) Arrangement of subunits in microtubules with 14 protofilaments. J. Cell Biol. 87:521-526.

Caplow, M., Langford, G.M. and Zeeberg, B. (1982) Concerning the efficiency of the treadmilling phenomenon with microtubules. J. Biol. Chem. 257:15012-15021.

Langford, G.M., Allen, R.D. and Weiss, D.G. (1987) Substructure of sidearms on squid axoplasmic vesicles and microtubules visualized by negative contrast electron microscopy. Cell Motil. Cytoskel. 7:20-30.

Seitz-Tutter, D., Langford, G.M. and Weiss, D.G. (1988) Dynamic instability of native microtubules from squid axons is rare and independent of gliding and vesicle transport. Exptl. Cell Res. 178:504-511.

Weiss, D.G., Langford, G.M., Seitz-Tutter, D. and Keller, F. (1988) Dynamic instability and motile events of natirve microtubules from squid axoplasm. Cell Motil. Cytoskel. 10:285-295.

Weiss, D.G., Meyer, M.A., and Langford, G. M. (1990) Studying axoplasmic transport by video microscopy and using the squid giant axon as a model system. In: Squid as Experimental Animals. Gilbert, D.L., Adelman, W.J., and Arnold, J.M. (eds.) Plenum Publishing Corp. pp.303-321.

Weiss, D.G., Seitz-Tutter, D. and Langford, G.M. (1991) Characteristics of the motor responsible for the gliding of native microtubules from squid axoplasm. J. Cell Sci. Suppl., 14:157-161.

Kuznetsov, S.A., Langford, G.M., and Weiss, D.G. (1992) Actin-dependent organelle movement in squid axoplasm. Nature 356:725-727.

Kuznetsov, S.A., D.T. Rivera, F.F. Severin, D.G. Weiss, and G.M. Langford. (1994) Axoplasmic organelle motility on actin filaments from skeletal muscle. Cell Motil. Cytoskel. 28:231-242.

Langford, G.M., S.A. Kuznetsov, D. Johnson, D. Cohen, and D.G. Weiss. (1994) Movement of axoplasmic organelles on actin filaments assembled on acrosomal processes: Evidence for a barbed-end directed organelle motor. J. Cell Sci. 107:2291-2298.

Langford, G.M. (1995) Actin- and microtubule-dependent organelle motors: interrelationship between the two motility systems. Current Opinion in Cell Biol. 7:82-88.

Waterman-Storer CM. Karki SB. Kuznetsov SA. Tabb JS. Weiss DG. Langford GM. Holzbaur EL. (1997) The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport. Proceedings National Academy of Sciences USA. 94:12180-5.

Molyneaux, B. J. and Langford, G. M. (1997) Characterization of antibodies to the head and tail domains of squid brain myosin V. Biol. Bull. 193:222-223.

Steffen, W., Langford, G. M., Weiss, D. G., and Kuznetsov, S. A. (1997) Inhibition of microtubule-dependent, minus-end directed transport of axoplasmic organelles by an antibody specific for the intermediate chain of dynein. Biol. Bull. 193: 221-222.

Moyer, BD, Loffing, J, Schwiebert, EM, Loffing-Cueni, D, Halpin, PA, Karlson, KH, Ismailov, II, Guggino, WB, Langford, GM, Stanton, BA. (1998) Membrane trafficking of the cystic fibrosis gene product, cystic fibrosis transmembrane conductance regulator, tagged with green fluorescent protein in madin-darby canine kidney cells. J Biol Chem. 273:21759-68 (Published erratum appears in J Biol Chem 273:26256.

Langford, G.M. and Molyneaux, B.J. (1998) Myosin V in the brain: mutations lead to neurological defects. Brain Research Reviews 28:1-8.

Tabb, J. S., Molyneaux, B. J., Cohen, D. L., Kuznetsov, S. A., and Langford, G. M. (1998) Transport of ER vesicles on actin filaments in neurons by myosin V. J. Cell Sci. 111:3221-3234.

DePina, A. S. and Langford, G. M. (1999). Vesicle transport: The role of actin filaments and myosin motors. Microscopy Res. Technique 47:1-14.

Langford, G. M. (1999). ER muscles its way around neurons. News Physiol. Sci. 14:175-175.

Woellert, T. DePina, A.S. and Langford, G.M. (1999). The effects of vanadate on actin-dependent vesicle motility in extracts of clam oocytes. Biol. Bull. 197:41-42.