Dunlap and Loros Laboratories
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Research
Our laboratories and research are directed towards understanding the mechanism by which eukaryotic organisms keep time on a daily basis, and how this capacity to keep time is used to regulate metabolism and development. Circadian clocks with fundamentally identical characteristics are found in all groups of eukaryotic organisms, but the uses to which these clock are put reflects the diversity of evolution. Phylogenetically this ranges from the control of cell division and enzyme activities in unicells, to a firmly established involvement in plant and animal photoperiodism and in avian and insect celestial navigation, to multiplicity of human systems including endocrine function, work-rest cycles and sleep, and drug tolerances and effectiveness.
Publications
Transcriptional rewiring of an evolutionarily conserved circadian clock.
Goity A, Dovzhenok A, Lim S, Hong C, Loros J, Dunlap JC, Larrondo LF
EMBO J. 2024 Apr 16; doi: 10.1038/s44318-024-00088-3. Epub 2024 Apr 16.
PMID: 38627599
Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock.
Tariq D, Maurici N, Bartholomai BM, Chandrasekaran S, Dunlap JC, Bah A, Crane BR
Elife. 2024 Mar 25;12 doi: 10.7554/eLife.90259. Epub 2024 Mar 25.
PMID: 38526948
Contact Us
Electronic Mail
Please send all general email to:
Jay.C.Dunlap@Dartmouth.edu
Jennifer.Loros@Dartmouth.edu
Telephone
Jay Dunlap: (603) 650-1108
Jennifer Loros: (603) 650-1154
Lab: (603) 650-1120
Fax
(603) 650-1233