Undergraduate Research with Gordon W. Gribble:


1. Alan D. Neubert, "A Brief Synthetic Study of Indolo[2,3-a]quinolizines," 1969.

2. David F. Tee, "An Approach to the Synthesis of 4-Fluoro-5-methylfluorene," 1969.

3. N. Roy Easton, Jr., "Study of Slow Nitrogen Inversion in Bridged Heterocycles," 1970.

4. Michael S. Smith, "The Effect of a Phenyl Substituent Upon the Solvolysis Rate of Benzhydryl Chloride," 1970.

5. James R. Douglas, Jr., "Long-range Hydrogen-Fluorine Coupling in Bridged Biphenyls," 1970.

6. Richard D. Kayne, "Long-range Proton-Fluorine Spin-Spin Coupling in Bridged Biphenyls," 1970.

7. Franklyn P. Bousquet III, "Deshielding Effects in the NMR Spectra of ortho-Substituted Anilides and Thioanilides," 1971.

8. Gregory C. Karnaze, "Through-Space Coupling," 1971.

9. Peter Kalafarski, "Computer Peak Detection and Integration of Simulated NMR Spectra," 1972.

10. Richard A. Larson, "The Preparation of Enamines by the Partial Reduction of Amides," 1972.

11. Keith W. Haden, "Proton-Fluorine Coupling in 1-Fluoro-8-methylnaphthalene," 1972.

12. G. Peter Erspamer, "Synthesis of 2-(2-Piperidyl)indole," 1972.

13. James S. K. Wu, "A Synthetic Study of the Conversion of Tetrahydro-b-carbolines into 2-Acylindoles," 1972.

14. John K. Sanstead, "A New Synthesis of Muscalure, The Sex Attractant of the House Fly," 1972.

15. Harley Kaufman, "An Improved Synthesis of Elaeocarpidine," 1973.

16. Robert T. Slayton, "Synthesis of New Compounds for the Study of Restricted Nitrogen Inversion," 1973.

17. Walter E. Donat, "New Techniques in the Synthesis of Indole Alkaloids," 1973.

18. Stephen E. Dietz, "Reductive Alkylation of Aniline, Quinoline, and Isoquinoline," 1974.

19. Duncan C. Ferguson, "Selective Reductions of Aldehydes in the Presence of Ketones with Sodium Triacetoxyborohydride," 1975.

20. Robert M. Leese, "The Alkylation of 5H-Dibenz(b,f)azepine and the Hydrogenolysis of Alcohols and Ketones with Sodium Borohydride in Carboxylic Acids," 1975.

21. Peter W. Heald, "Reductive/Alkylation of Quinoline and Isoquinoline with Sodium Borohy dride in Carboxylic Acids," 1975.

22. Marcus A. Tius, "The Synthesis of Some Callicarpone Precursors," 1975.

23. Warren J. Kortz, "Alkylation of Aniline Derivatives in Trifluoroacetic Acid-Sodium Boro hydride and in Oxalic Acid-Sodium Borohydride Media," 1975.

24. Jay Leiter, "Attempted Synthesis of 7-Benzyl- and 7-Ethyl-1,7-diazanorbornanes and Analo gous 1-Azanorbornanes for Low Temperature Nitrogen Inversion NMR Studies," 1975.

25. James E. O'Neil, Jr., "Attempted Isolation of Callicarpone and A New Reduction of Anthraquinones," 1975.

26. Michael C. Venuti, "Preliminary Investigations into Some Versatile Syntheses of Polynuclear Hydrocarbon Precursors," 1975.

27. Joseph M. Jasinski, "Reactions of Aliphatic Amines with Sodium Borohydride/Carboxylic Acids," 1975.

28. Kenneth C. Parker, "An Approach to the Synthesis of Callicarpone," 1975.

29. Jeffrey M. Rieker, "Aryne Cycloaddition to Substituted 1,2,4-Triazoles and 1,3,4-Oxadia zoles: A New Synthetic Route to Polycyclic Aromatic Hydrocarbons," 1976.

30. John T. Pellicone, "Reductive Alkylation of Primary and Secondary Aliphatic Amines with Sodium Borohydride and Carboxylic Acids," 1976.

31. Edward J. Holubowitch, "Diels-Alder Addition of Dibromoquinodimethane Intermediates to Quinone and Imine Dieneophiles: A Versatile Synthesis of Polynuclear Aromatic Hydrocarbon Precursors," 1976.

32. John H. Urbanowicz, "Selective Hydrolysis of Amides and Nitriles in the Presence of an Ester Function," 1976.

33. Peter B. H'Doubler, Jr., "The Synthesis of Precursors of 1.2,3.4-Dibenzanthracene: an Investigation of a New Route to Carcinogenic Polynuclear Aromatic Hydrocarbons. Detection of Carcinogens as Mutagens: Assay of Four Polynuclear Aromatic Hydrocarbons," 1977.

34. Jay M. Brown, "Protecting Groups at the 1-Position of Indole," 1977.

35. Joseph H. Hoffman, "Reduction of Indoles with Sodium Cyanoborohydride in Acetic Acid," 1977.

36. Myles N. Sheehan, "Sodium Borohydride Reduction of Oximes in Carboxylic Acid Media," 1977.

37. Jeffrey J. Gilbertson, "Diels-Alder Addition of Naphthalyne and Azadienes with Subsequent Cheletropic Bridge Extrusion: A New Synthetic Route to Polycyclic Aromatic Hydrocar bons," 1977.

38. David Kassel, "Reductive Amination Utilizing Sodium Borohydride in Liquid Ammonia," 1977.

39. Allan F. Cunningham, Jr., "Attempts at the Synthesis of Tecomanine," 1979.

40. J. Tom Sullebarger, "A Partial Synthesis of Lepistine, a Fungal Alkaloid," 1979.

41. David C. Perlman, "Diels-Alder Addition of Quinodimethane Intermediates to Quinone and Imine Dienophiles: Details of a Versatile Synthesis of Polynuclear Aromatic Hydrocarbon Precursors," 1979.

42. Amy L. Ladd, "Trifluoroacetic Acid-Promoted Friedel-Crafts Aromatic Alkylations," 1979.

43. John N. D'Albis, "A Study and Synthesis of Precursors to Pentaprismane," 1980. Pilot Software

44. Stephen W. Wright, "The Mechanism of the Reduction of Quinoline in Sodium Borohydride and Acetic Acid; Synthesis, Rearrangement, Reduction, and Alkylation of Diindole," 1981.

45. Ray D. Hiley, "Synthetic Routes to 4-Cycloheptenone," 1981.

46. John W. Haas III, "NMR Studies of a Bridged-Biphenyl System," 1981.

47. Howard Tung, "Synthetic Routes to a-Methyl-g-isopropylbutyrolactone," 1981.

48. Mark A. Pals, "H-F and C-F Long-Range and Through-Space Spin-Spin Coupling," 1982.

49. Robert B. Conley, "Synthesis of Elaeokanines A and D: Maximization of Yields of Two Precursors," 1982.

50. Charles B. Cairns, "Synthesis of Elaeokanine D: Utilization of a Convergent Approach to the Synthesis of Elaeocarpus Alkaloids," 1982.

51. Steven M. Schreiber, "A Novel Approach to Ellipticine Synthesis," 1982.

52. Russell L. Gombosi, "A Novel Approach to the Synthesis of 2-Methyl-5-azaisoindole," 1982.

53. Mark S. Meier, "A Novel Synthetic Approach to the Sarpagine-Vobasine Alkaloids," 1982.

54. Philip G. Hultin, "Diels-Alder Synthesis of the Higher Acenes," 1983.

55. John M. Sum, "9-Fluoroellipticine," 1983.

56. Gillian L. Fletcher, "The Synthesis of Possible Anti-Cancer Active Pyridocarbazoles," 1984.

57. Steve J. Compton, "Synthetic Approaches to Two Natural Products of the Marine Sponge Halichondria melanodocia," 1984.

58. Karen S. Harpp, "Towards Symmetry - A Novel Synthetic Approach to Pentaprismane and Azapentaprismane," 1986.

59. E. James Gruver II, "A Synthetic Approach to 7,8,9,10-Tetrafluoroellipticine," 1986.

60. Erik J. Roskes, "Synthetic Approaches to Several Anticancer Alkaloids," 1986.

61. Todd M. Dubois, "Anticancer Alkaloid Synthesis," 1987 (NSF REU Program).

62. Michael J. Lelis, "Metalation of Heterocycles," 1987 (NSF REU Program).

63. Nancy B. Thornton, "Synthesis of 1,12-Di(2-(1-hydroxyethyl)-1-(phenylsulfonyl)-3-indolyl)dodecane," 1989 (NSF REU Program).

64. Denise M. Perreault, "Synthesis of 1,12-Di(2-(1-hydroxyethyl)-1-(phenylsulfonyl)-2-indolyl)dodecane," 1989 Zimmerman Foundation Fellowship from Wellesley College.

65. Cornelius W. Van Niel, "A Novel Synthetic Route to 9-Azaellipticine," 1990.

66. Kimberly Dirlam, "Synthesis of 13-Oxoellipticine," 1990 (NSF REU Program).

67. Ronald C. Horton, "Attempted Synthesis of Ellipticine," 1990 (Hughes Undergraduate Fellowship).

68. Christopher J. Winfree, "Conformationally-Restricted bis(9-Aminoacridine)s as Novel Antitumor Agents: Synthesis, Cytotoxicity, and Fluorescence Spectroscopy," 1991.

69. Keith C. Dangleis, "The Attempted Synthesis of 1,10-bis-[3-Methyl-4-(phenylsulfonyl)-4H-furo[3,4-b]-1-indolyl]decane," 1991.

70. Brett D. Allison, "I. Synthetic Studies on 2- and 3-Haloindoles: Preparation and Reactions of 2-Bromo-3-iodo-N-(phenylsulfonyl)indoles; Synthesis of a Radical Cyclization Precursor. II. On the Direct Acetylation of the N-(Phenylsulfonyl)indole 2-Anion," 1993.

71. William A. Novomisle, "Synthesis and Remote Directed Metalation Studies of a Fluorenyl Amide," 1993 (FROC Participant); "Novel Synthetic Approaches to the Generation of g-Carbolines," 1996.

72. Michelle A. Bianco, "Isolation of Biologically Active Marine Natural Products," 1993 (Presidential Scholars Program and 1993 NSF REU Program); "Extraction, Isolation and Characterization of Biologically Active Compounds from Caribbean Marine Organisms" 1994.

73. George T. Topalov, "Novel Approaches to Indolo-2,3-quinodimethanes," 1993-94 (Presidential Scholars Program); "Synthesis of Scytonemin, a Novel Algal Sunblock," 1993-1995. After a PhD with Yoshito Kishi at Harvard, George is now at Array Biopharma in Boulder, Colorado.

74. Amy Semet, "Marine Organism Natural Products," WISP intern, 1994.

75. Lesley Meister, "Marine Organism Natural Products," FROC intern, 1994.

76. Vijay Shankaran, "Bis(9-Aminoacridines): 3-Dimensional Structure Correlated to Cytotoxicity and Gene Expression Effects," 1994 (co-advisor with Josh Hamilton).

77. Kerri Cavanaugh, "Novel Approaches to Indolo-2,3-quinodimethanes," 1995.

78. Paul F. LaFlam, "Nucleophilic Additions to Electron-Deficient Indoles," 1995.

79. Matthew R. Reese, "Towards Pentaprismane: a Synthetic Approach via a Model Study of 9,11-Diphenyl-10-azatetracyclo[,11)0.(5,9)]undecane," 1995.

80. Wendy M. Jastremski, "Extraction and Separation of Marine Natural Products and Their Biomedical Applications," 1995.

81. Louis Chang, "Preparation and Reactions of 2- and 3-Nitroindoles," (library research project), 1994-1995; American Cyanamid Fellow, Summer 1995 (same title); 1996.

82. David Aronchick, "Sea Fan Diterpenes," (library research project), 1994-1995.

83. Adam C. Lipson, "The Synthesis of 2,3-Dicyanoindole as a Novel Dienophile," 1995.

84. David Hung, "Marine Natural Products -- A Literature Survey," FROC, 1994-1995.

85. Dana Smith, "Natural Chlorinated Compounds -- A Literature Survey," 1995.

86. Tony Baptista, "Marine Natural Products Isolation and Synthesis of Convolutamydines," Howard Hughes Summer Research Fellow, 1995.

87. Nicolay Stoyanov, "NMR Analysis of Natural Products," First-Year Summer Research Project, 1995.

88. John Davis, "Attempted Synthesis of Isoellipticine for the Purpose of Testing as an Anti-Tumor Agent," 1996.

89. Benjamin M. Brainard, "Isolation of Chemopreventive New England Plant Natural Products," Richter Fellow, 1994-1995; "A Survey of the Antibiotic and Anticancer Properties of Local New Hampshire Plants and Fungi," 1996.

90. Erick Lemley, "Barton-Style Nucleophilic Addition to Nitro-Activated Heteroaromatic Ring Systems," 1996.

91. Alex Fay, "Two Novel Pathways to Isolable Indole-2,3-quinodimethane," 1996 (NSF REU Program).

92. Fred D'Amato, "Investigation of Intramolecular 1,3-Dipolar Cycloadditions via Munchnone Formation," 1996 (NSF REU Program).

93. Michael Chong, "Synthesis of Mexican Bean Beetle Allomones," Presidential Scholar, 1996.

94. Shari Lipner, "A Study of the Beckmann Rearrangement on Cyclic Ketones, " Presidential Scholar, 1995-1996, and Chem 87 project, 1997.

95. Sarah C. Snyder, "Isolation, Identification and Biological Activity of Medicinal Plants of Mexico," Presidential Scholar, 1996-1997, and Reynolds Grant Recipient, 1997.

96. Wendy Simon, "Investigation into the Regioselectivity of 1,3- Dipolar Cycloaddtions Between Munchnones and Nitro- Substituted Heterocycles," 1997-1998.

97. Lisa Emerson, "Isolation of Biologically Active Compounds from Mexican Medicinal Plants," WISP intern, 1998.

98. Amanda Cook, "Isolation of Biologically Active Compounds from Mexican Medicinal Plants," WISP intern, 1998.

99. Catie Grimes, "Isolation of Triterpenes and Novel Biologically Active Compounds," 1997- 1999.

100. Nancy Forsyth, "A Free Radical Approach to Indoloquinodimethanes," 1998.

101. Justin Carter, "Modified Haloform Reaction on p- Excessive Heterocycles," 1998.

102. Karen Miller, "A New Approach to K-252a," 1998.

103. Heather Huffman, "Synthesis and Reactions of the Acyloxyborohydrides from Sodium Borohydride and Citric Acid," Presidential Scholar, 1998-1999.

104. Benjamin Malkin, " "A New Approach to K-252a," 1998.

105. Cindy Kan, "A Novel Approach to Pentaprismane," Howard Hughes Summer Internship, Barnard College, 1998.

106. Sarah C. Lievens, "A New Approach to K-252a," 1998-2000, "Novel Indole Chemistry" and "Synthesis of Novel Bipyroles" 1999-2000. Alternate email: sclievens@ucdavis.edu

107. Anne H. Nash, "Isolation of Triterpenes and Novel Biologically Active Compounds," 1999.

108. Cindy Oberto, "Isolation and Biological Activity of Natural Products from Fungi," 1999.

109. John S. Schneekloth Jr., "Synthesis and Identification of Halogenated Pyrroles and Naturally Occurring Halogenated Bipyrroles," 2000-2001.

110. Justin Mohr, "Synthesis of Polyhydroxyalkanes as Novel Anesthetics," Waterhouse grant, Chem 87, 2001-2003.

111. Michael Sinha, "Synthesis of Anti-tumor Alkaloids," Beckman Scholars Program Fellowship and Waterhouse Grant, Chem 87, 2001.

112. Sarah Garaas, "A Synthetic Approach to Novel Semi-rigid Bis-Intercalators," 2002.

113. Nate Senge, "Syntheses of CDDO Imidazolides," Glaxo Summer Fellowship, 2003.

114. Meredeth McGowan, "Syntheses and Biological Activity of Novel Tethered Antitumor Ellipticine Alkaloids," Presidential Scholar, Waterhouse grant, Chem 87, 2002-2004.

115. Tanisha Keshava, "Extraction Studies of Eurasian Milfoil," Presidential Scholar, 2003-2004.

116. Josh Payette, "Synthetic Studies of Tricyclic Bis-Enones," paid summer student, 2003 and 2004.

117. Michael Lauria, "Synthesis of Q1 and the Polyhalogenated Marine Bipyrroles," Zabriskie Fellow, Summer 2004.

118. Olga Barykina, "Novel Chemistry of 2- and 3-Cyanoindoles," paid summer student, 2004.

119. Alexa Hansen, "Synthesis of the Natural Bioaccumulative Organochlorine, Q1," 2004.

120. Michael Holmes, "Synthesis of Tricyclic Bis-Enones," Zabriskie Fellow, Summer student, 2006.

121. Marc Lajoie, "Improved Synthesis of 'Intermediate 9' and Design and Synthesis of New TBE-31 Analogues," Summer, 2007; Chem 87, 2007-2008 (working with Dr. Tadashi Honda).

122. Lingshan Wang, "Novel Syntheses of Biindoles," 2007-2008.

123. Eric Padegimas, "Design and Synthesis of New CDDO-acetylenic-imidazolides," Presidential Scholar, 2007-2008 (working with Dr. Tadashi Honda).

124. Katherine Schiavoni, "Synthesis of TBE-38 (cyanoacetylene) for Further Biological Evaluation," Presidential Scholar, 2008 (working with Dr. Tadashi Honda).

125. Jeff Cui, "Synthesis of Mono Cyclic Non-enolizable Cyano Enones," Presidential Scholar, 2007 (working with Dr. Tadashi Honda).

126. Gabriel Foster, "Synthesis of TBE-35 (Methylacetylene) for Further Biological Evaluation," Howard Hughes Scholar, 2008 (working with Dr. Tadashi Honda).

127. Shasta Small, "New Synthetic Approaches to Antitumor Indolocarbazoles," 2008-2009.

128. Sean Jones, "A New Synthetic Route to 2,3-Disubstituted Indoles," 2008-2009.

129. Joseph Kubert, “A Fischer Indole Approach to Biindoles,” Zabriskie Fellow , 2009-2010.

130. David Qian, “Double Functionalization of Nitroindoles,” Zabriskie Fellow, Presidential Scholar, 2009-2010.

131. Boer Deng, “Studies in the Synthesis of 2- and 3-Substituted 1-(Phenylsulfonyl)indole,” Zabriskie Fellow; Chem 87, 2009-2010.

132. Will Montgomery, “The Synthesis and Chemistry of Cyanoindoles,” 2009-2010.

133. Megan Johnson, “Novel Anticancer Bis-acridines,” Howard Hughes Scholar, 2009-2010.

134. Tasneem Khalid, “Design and Synthesis of Novel Anti-Malarial Hydroxynaphthoquinones,” Presidential Scholar, 2010-2011.

135. Mia Song, “1,3-Dipolar Cycloadditions of Electron-Deficient Alkenes and Unsymmetrical Azomethine Ylides,” Chem 87, 2010-2011.

136. Tim Abbot, “Progress Toward the Synthesis of Novel Biindole, 3-Alkyl-2-Hydroxy-1,4-Naphthoquinone, and Oleanane Heterocycles,” Class of ’86 Research Award, Chem 87, 2010-2012.

137. Rebecca Carton, “The Chemistry of Cyanoindoles,” visiting summer student, 2011.

138. Ramesh Govindan, “Novel Anticancer Bis-acridines,” Howard Hughes Scholar, 2010-2011.