1. The Structure of Arjungenin. A New Sapogenin from Terminalia ariuna. Honda, T.; Murae, T.; Tsuyuki, T.; Takahashi, T. Chem. Pharm. Bull. 1976, 24, 178-180.
2. Arjungenin, Arjunglucoside I, and Arjunglucoside II. A New Triterpene and New Triterpene Glucosides from Terminalia ariuna. Honda, T.; Murae, T.; Tsuyuki, T.; Takahashi, T; Sawai, M. Bull. Chem. Soc. Jpn. 1976, 49, 3213-3218.
3. Olean-18-ene Derivatives with a 13aH-Configuration. Honda, T.; Murae, T.; Tsuyuki, T.; Takahashi, T. Chem. Lett. 1977, 271-274.
4. 13aH-Olean-18-ene Derivatives. Forced Wolff-Kishner Reduction Products of 19-Oxoolean-12-ene Derivatives. Honda, T.; Murae, T.; Tsuyuki, T.; Takahashi, T. Bull. Chem. Soc. Jpn. 1978, 51, 884-888.
5. A New Triterpene Glucoside from Terminalia ariuna. Arjunglucoside III. Tsuyuki, T.; Hamada, Y.; Honda, T.; Takahashi, T.; Matsushita, K. Bull. Chem. Soc. Jpn. 1979, 52, 3127-3128.
6. Synthesis of (±)-3,3-Ethylenedioxy-14a-hydroxy-5-picrasene-11,16-dione, a 14aH-Picrasane Derivative. Honda, T.; Murae, T.; Ohta, S.; Kurata, Y.; Kawai, H.; Takahashi, T.; Itai, A.; Iitaka Y. Chem. Lett. 1981, 299-302.
7. Structures of Yadanziolides A, B, and C, New Bitter Principles from Brucea javanica. Yoshimura, S.; Sakaki, T.; Ishibashi, M.; Tsuyuki, T.; Takahashi, T.; Matsushita, K.; Honda T. Chem. Pharm. Bull. 1984, 32 , 4698-4701.
8. New Quassinoid Glycosides, Yadanziosides A-H, from Brucea javanica. Sakaki, T.; Yoshimura, S.; Ishibashi, M.; Tsuyuki, T.; Takahashi, T.; Honda, T.; Nakanishi, T. Chem. Pharm. Bull. 1984, 32 , 4702-4705.
9. Constituents of Seeds of Brucea javanica. Structures of New Bitter Principles, Yadanziolides A, B, C, Yadanziosides F, I, J, and L. Yoshimura, S.; Sakaki, T.; Ishibashi, M.; Tsuyuki, T.; Takahashi, T.; Honda, T. Bull. Chem. Soc. Jpn. 1985, 58, 2673-2679.
10. Structures of New Quassinoid Glycosides, Yadanziosides A, B, C, D, E, G, H, and New Quassinoids, Dehydrobrusatol and Dehydrobruceantinol from Brucea javanica (L.) Merr. Sakaki, T.; Yoshimura, S.; Ishibashi, M.; Tsuyuki, T.; Takahashi, T.; Honda, T.; Nakanishi, T. Bull. Chem. Soc. Jpn. 1985, 58, 2680-2686.
11. Two New Quassinoid Glycosides, Yadanziosides N and O Isolated from Seeds of Brucea javanica (L.) Merr. Sakaki, T.; Yoshimura, S.; Tsuyuki, T.; Takahashi, T.; Honda, T.; Nakanishi, T. Tetrahedron Lett. 1986, 27 , 593-596.
12. Structures of Yadanziosides K, M, N, and O, New Quassinoid Glycosides from Brucea javanica (L.) Merr. Sakaki, T.; Yoshimura, S.; Tsuyuki, T.; Takahashi, T.; Honda, T., Nakanishi, T. Bull. Chem. Soc. Jpn. 1986, 59 , 3541-3546.
13. Yadanzioside P, a New Antileukemic Quassinoid Glycoside from Brucea javanica (L.) Merr with The 3-O-(b-D-Glucopyranosyl)bruceantin Structure. Sakaki, T.; Yoshimura, S.; Tsuyuki, T.; Takahashi, T.; Honda, T. Chem. Pharm. Bull. 1986, 34, 4447-4450.
14. Preparation of a Tricyclic A-Ring Analog of Quassin. Kurata, K.; Hirota, H.; Honda, T.; Takahashi, T. Chem. Pharm. Bull. 1987, 35 , 837-840.
15. Studies on Antitumor Activity of Quassinoids: Synthesis and Antitumor Activity of Novel Ailanthone Analogues. Honda, T.; Imao, K.; Inoue-Shiraishi, M.; Nakatsuka, N.; Tatsuoka, T.; Nakanishi, T.; Noguchi, T. J. Pharmacobio-Dyn. 1987, 10, s-61.
16. Stereoselective Synthesis of 9-Hydroxyellipticine Glycosides, Novel and Highly Active Antitumor Agents. Honda, T.; Inoue, M.; Kato, M.; Shima, K.; Shimamoto, T. Chem. Pharm. Bull. 1987, 35, 3975-3978.
17. Yadanziolide D, a New C19-Quassinoid Isolated from Brucea javanica (L.) Merr. Yoshimura, S.; Ogawa, K.; Tsuyuki, T.; Takahashi, T.; Honda, T. Chem. Pharm. Bull. 1988, 36 , 841-844.
18. Antitumor Activity of Novel Ailanthone Derivatives in Vitro and in Vivo. Kato, T.; Suzumura, Y.; Fukushima, M.; Honda, T.; Nakanishi, T.; Noguchi, T. Anticancer Res. 1988, 8, 573-580.
19. Synthesis and Antitumor Activity of Quaternary Ellipticine Glycosides, a Series of Novel and Highly Active Antitumor Agents. Honda, T.; Kato, M.; Inoue, M.; Shimamoto, T.; Shima, K.; Nakanishi, T.; Yoshida, T.; Noguchi, T. J. Med. Chem. 1988, 31, 1295-1305.
20. Studies on SUN4599 (2-a-L-Arabinopyranosyl-9-hydroxyellipticinium Bromide), a Novel and Highly Active Antitumor Agent. Honda, T.; Kato, M.; Shimamoto, T.; Inoue, M.; Shima, K.; Nakanishi, T.; Noguchi, T. J. Pharmacobio-Dyn. 1989, 12, s-l39.
21. A Novel Antitumor Agent, SUN4599, an Ellipticine Glycoside (1) - Antitumor Activity against Murine Tumors. Tsukagoshi, S.; Tsuruo, T.; Nakanishi, T.; Honda, T.; Noguchi, T.; Nitta, K. J. Cancer Res. Clin. Oncol. 1990, 116 , 443.
22. A Novel Antitumor Agent, SUN4599, an E1lipticine Glycoside (2) - Effect against Human Tumor Cells. Nitta, K.; Fujimoto, S.; Tokita, H; Kunimoto, T.; Baba, H.; Nakanishi, T.; Honda, T.; Noguchi, T.; Tsukagoshi, S. J. Cancer Res. Clin. Oncol. 1990, 116 , 442.
23. A Novel Antitumor Agent, SUN4599, an Ellipticine Glycoside (3) - Mechanism of Action. Tsuruo, T.; Kunimoto, T.; Baba, H.; Nakanishi, T.; Honda, T.; Noguchi, T.; Tsukagoshi, S.; Nitta K. J. Cancer Res. Clin. Oncol. 1990, 116, 442.
24. Drug Delivery through Condensation of Two Prodrugs inside Tumor Cells: Direct Observation Using Fluorescence Microscopy. Honda, T.; Rideout, D.; McCarthy, M.; McCracken, T.; Jaworski, J. Proc. Am. Assoc. Cancer Res. 1991, 32, 419.
25. Structure&endash;Activity Relationship Study on N-Glycosyl Moieties through Model Building of DNA and Ellipticine N-Glycoside Complex. Shimamoto, T.; Imajo, S.; Honda, T.; Yoshimura, S.; Ishiguro, M. Bioorg. Med. Chem. Lett. 1996, 6, 1331-1334.
26. New Enone Derivatives of Oleanolic Acid and Ursolic Acid as Inhibitors of Nitric Oxide Production in Mouse Macrophages. Honda, T.; Finlay, H. J.; Gribble, G. W.; Suh, N.; Sporn, M. B. Bioorg. Med. Chem. Lett. 1997, 7 , 1623-1628.
27. Novel A-Ring Cleaved Analogs of Oleanolic and Ursolic Acids Which Affect Growth Regulation in NRP.152 Prostate Cells. Finlay, H. J.; Honda, T.; Gribble, G. W.; Danielpour, D.; Benoit, N. E.; Suh, N.; Williams, C.; Sporn, M. B. Bioorg. Med. Chem. Lett. 1997, 7, 1769-1772.
28. Partial Synthesis of Krukovine A and B, Triterpene Ketones Isolated from the Brazilian Medicinal Plant Maytenus krukovii. Honda, T.; Finlay, H. J.; Gribble, G. W. J. Nat. Prod. 1997, 60, 1174-1177.
29. Novel Triterpenoids Suppress Inducible Nitric Oxide Synthase (iNOS) and Inducible Cyclooxygenase (COX-2) in Mouse Macrophages. Suh, N.; Honda, T.; Finlay, H. J.; Barchowsky, A.; Williams, C.; Benoit, N. E.; Xie, Q.-w.; Nathan, C.; Gribble, G. W.; Sporn, M. B. Cancer Res. 1998, 58 , 717-723.
30. Design and Synthesis of 23,24-Dinoroleanolic Acid Derivatives, Novel Triterpenoid- Steroid Hybrid Molecules. Honda T.; Gribble, G. W. J. Org. Chem. 1998, 63, 4846-4849.
31. Design and Synthesis of 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid, a Novel and Highly Active Inhibitor of Nitric Oxide Production in Mouse Macrophages. Honda, T.; Rounds, B. V.; Gribble, G. W.; Suh, N.; Wang, Y.; Sporn, M. B. Bioorg. Med. Chem. Lett. 1998, 8, 2711-2714.
32. A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid, with Potent Differentiating Anti-proliferative, and Anti-inflammatory Activity. Suh, N.; Wang, Y.; Honda, T.; Gribble, G. W.; Dmitrovsky, E.; Hickey, W. F.; Maue, R. A.; Place, A. E.; Porter, D. M.; Spinella, M. J.; Williams, C. R.; Wu, C.; Dannenberg, A. J.; Flanders, K. C.; Letterio, J. J.; Mangelsdorf, D. J.; Nathan, C. F.; Nguyen, L.; Porter, W. W.; Ren, R. F.; Roberts, A. B.; Roche, N. S.; Sutbaramaiah, K.; Sporn, M. B. Cancer Res. 1999, 59 , 336-341.
33. Novel Synthetic Oleanane Triterpenoids: A Series of Highly Active Inhibitors of Nitric Oxide Production in Mouse Macrophages. Honda, T.; Rounds, B. V.; Bore, L.; Favaloro, Jr., F. G.; Gribble, G. W.; Suh, N.; Wang, Y.; Sporn, M. B. Bioorg. Med. Chem. Lett. 1999, 9, 3429-3434.
34. Novel Synthetic Oleanane and Ursane Triterpenoids with Various Enone Functionalities in Ring A as Inhibitors of Nitric Oxide Production in Mouse Macrophages. Honda, T.; Gribble, G. W.; Suh, N.; Finlay, H. J.; Rounds, B. V.; Bore, L.; Favaloro, Jr., F. G.; Wang, Y.; Sporn, M. B. J. Med. Chem. 2000, 43, 1866-1877.
35. The Novel Triterpenoid 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid Induces Apoptosis of Human Myeloid Leukemia Cells by a Caspase-8-dependent Mechanism. Ito, Y.; Pandey, P.; Place, A.; Sporn, M. B.; Gribble, G. W.; Honda, T.; Khabanda, S.; Kufe, D. Cell Growth Differ. 2000, 11, 261-267.
36. Synthesis of b-Boswellic Acid Analogues with a Carboxyl Group at C-17 Isolated from the Bark of Schefflera octophylla. Bore. L.; Honda, T.; Gribble. G. W. J. Org. Chem. 2000, 65, 6278-6282.
37. A Synthetic Triterpenoid, 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid (CDDO), Is a Ligand for the Peroxisome Proliferator-activated Receptor g. Wang, Y.; Porter, W. W.; Suh, N.; Honda, T.; Gribble, G. W.; Leesnitzer, L. A.; Plunket, K. D.; Mangelsdorf, D. J.; Blanchard, S. G.; Willson, T. M.; Sporn, M. B. Mol. Endocrinol. 2000, 14, 1550-1556.
38. Synthetic Oleanane and Ursane Triterpenoids with Modified Rings A and C: A Series of Highly Active Inhibitors of Nitric Oxide Production in Mouse Macrophages. Honda, T.; Rounds, B. V.; Bore, L.; Finlay, H. J.; Favaloro, Jr., F. G.; Suh, N.; Wang, Y.; Sporn, M. B.; Gribble, G. W. J. Med. Chem. 2000, 43 , 4233-4246
39. Novel Synthetic Triterpenoid CDDO-Me Is a Potent Inducer of Apoptosis and Differentiation in Acute Myelogenous Leukemia. Konopleva, M.; Tsao, T.; Ruvolo, P.; Stiouf, I.; Estrov, Z.; Leysath, C.; Zhao, S.; Harris, D.; Chang, S.; Jackson, C. E.; Munsell, M.; Suh, N.; Gribble, G.; Honda, T.; May, S.; Sporn, M.; Andreeff, M. Blood 2002, 99, 326-335.
40. Identification of a Novel Synthetic Triterpenoid, Methyl 2-Cyano-3,12-dioxooleana-1,9-dien-28-oate, That Potently Induces Caspase-mediated Apoptosis in Human Lung Cancer Cells. Kim, K. B.; Lotan, R.; Yue, P.; Sporn, M. B.; Suh, N.; Gribble, G. W.; Honda, T.; Wu, G. S.; Hong, W. K.; Sun, S.-Y. Mol. Cancer Ther. 2002, 1, 177-184.
41. The Anti-inflammatory Triterpenoid Methyl 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oate Methanol Solvate Hydrate. Bore, L.; Honda, T.; Gribble, G. W.; Lork, E.; Jasinski, J. P. Acta Cryst. 2002, C58, 199-200.
42. A Novel Dicyanotriterpenoid, 2-Cyano-3,12-dioxooloana-1,9(11)-dien-28-onitrile, Active at Picomolar Concentrations for Inhibition of Nitric Oxide Production. Honda, T.; Honda, Y.; Favaloro, Jr., F. G.; Gribble, G. W.; Suh, N.; Place, A. E.; Rendi, M. H.; Sporn, M. B. Bioorg. Med. Chem. Lett. 2002, 12, 1027-1030.
43. Partial Synthesis of 23-Hydroxyursolic Acid Isolated from Medicinal Plants of the Rubiaceae Family. Bore, L.; Honda, T.; Gribble, G. W. Nat. Prod. Lett. 2002, 16, 273-276.
44. Design and Synthesis of Tricyclic Compounds with Enone Functionalities in rings A and C: A Novel Class of Highly Active Inhibitors of Nitric Oxide Production in Mouse Macrophages. Favaloro, Jr., F. G.; Honda, T.; Honda, Y.; Gribble, G. W.; Suh, N.; Risingsong, R.; Sporn, M. B. J. Med. Chem. 2002, 45, 4801-4805.
45. Synthesis of Novel [3,2-b]Indole Fused Oleanolic Acids as Potential Inhibitors of Cell Proliferation. Finlay, H. J.; Honda, T.; Gribble, G. W. ARKIVOC
2002, 12, 38–46.
46. Synthetic Triterpenoids Enhance Transforming Growth Factor b/Smad Signaling. Suh, N.; Roberts, A. B.; Reffey, S. B.; Miyazono, K.; Itoh, S.; ten Dijke, P.; Heiss, E. H.; Place, A. E.; Risingsong, R.; Williams, C. R.; Honda, T.; Gribble, G. W.; Sporn, M. B. Cancer Res.
2003, 63, 1371–1376.
47. Revision and Confirmation of the Regiochemistry of Isoxazoles Derived from Methyl Oleanonate and Lanost-8-en-3-one. Synthesis of a New Lanostane Triterpenoid with a Cyano-enone Functionality in Ring A. Honda, Y.; Honda, T.; Roy, S.; Gribble, G. W. J. Org. Chem.
2003, 68, 4991–4993.
48. The Novel Synthetic Triterpenoid, CDDO-Imidazolide, Inhibits Inflammatory Response and Tumor Growth in Vivo. Place, E. A.; Suh, N.; Williams, C. R.; Risingsong, R.; Honda, T.; Honda, Y.; Gribble, G. W.; Leesnitzer, L. M.; Stimmel, J. B.; Willson, T. M.; Rosen, E.; Sporn, M. B. Clin. Cancer Res.
2003, 9, 2798–2806.
49. The Novel Triterpenoid CDDO and Its Derivatives Induce Apoptosis by Disruption of Intracellular Redox Balance. Ikeda, T.; Sporn, M.; Honda, T.; Gribble, G. W.; Kufe, D. Cancer Res.
2003, 63, 5551–5558.
50. Efficient Synthesis of (–)- and (+)-Tricyclic Compounds with Enone Functionalities in Rings A and C. A Novel Class of Orally Active Anti-inflammatory and Cancer Chemopreventive Agents. Honda, T.; Favaloro, F. G., Jr.; Janosik, T.; Honda, Y.; Suh, N.; Sporn, M. B.; Gribble, G. W. Org. Biomol. Chem.
2003, 1, 4384–4391.
51. The Bortezomib/Proteasome Inhibitor PS-341 and Triterpenoid CDDO-Im Induce Synergistic Anti-multiple Myeloma (MM) Activity and Overcome Bortezomib Resistance. Chauhan, D.; Li, G.; Podar, K.; Hideshima, T.; Shringarpure, R.; Catley, L.; Mitsiades, C.; Munshi, N.; Tai, Y. T.; Suh, N.; Gribble, G. W.; Honda, T.; Schlossman, R.; Richardson, P.; Sporn, M. B.; Anderson, K. C. Blood
2004, 103, 3158–3166.
52. Design, Synthesis, and Biological Evaluation of Biotin–Conjugates of 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid (CDDO) for the Isolation of the Protein Targets. Honda, T.; Janosik, T.; Honda, Y.; Han, J.; Liby, K. T.; Williams, C. R.; Couch, R. D.; Anderson, A. C.; Sporn, M. B.; Gribble, G. W. J. Med. Chem.
2004, 47, in press.