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Dartmouth Medical School
Department of Genetics
7400 Remsen
Hanover, NH 03755
Genetics.Department@Dartmouth.edu
603/650-1907

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Department Publications 2008

  • Takacs, C.M., Baird, J.R., Hughes, E.G., Kent, S.S., Benchabane, H., Paik, R. and Ahmed, Y. Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli. Science 319:333-336 (2008). Full Text.
  • Benchabane, H., Hughes, E.G., Takacs, C.M., Baird, J.R. and Ahmed, Y. Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen. Development 135:963-971 (2008). Cover Article.
  • Loring, G.L., Christensen, K.C., Gerber, S.A. and Brenner, C. Yeast Chfr Homologs Retard Cell Cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-Dependent Ubiquitination. Cell Cycle 7:95-105 (2008).
  • Fuller, R.S. Bambara, R.A., Baker, T., Funnell, B., Wahle, E., O'Donnell, M., Kaiser, D., Skarstad, K., Konforti, B., Maki, S., Katayama, T., Sekimizu, K., Weiner, J.H., Davis, R.W., Rowen, L., Goodman, M.F., Spudich, J., Pfeffer, S., Richardson, C.C., Polaczek, P., Calendar, R., Kolodner, R., Griffith, J., Stillman, B., Modrich, P., Brenner. C. and Yanofsky, C. A Tribute to Arthur Kornberg, 1918-2007. Nat Struct Mol Biol 15:2-17 (2008).
  • Belenky, P.A., Mogu, T.G. and Brenner, C.S. cerevisiae YOR071C Encodes the High Affinity Nicotinamide Riboside Transporter, Nrt1." J Biol Chem, 283:8075-8079 (2008).
  • Linster, C.L., Adler, L.T., Webb, K., Christensen, K.C., Brenner. C. and Clarke, S.G. A Second GDP-L-Galactose Phosphorylase in Arabidopsis en Route to Vitamin C: Covalent Intermediate and Substrate Requirements for the Conserved Reaction. J Biol Chem 283:18483-18492 (2008).
  • Bogan, K.L. and Brenner, C. Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition. Ann Review Nutrition v. 28, in press (2008).
  • Brooks, L. III, Heimsath, E.G., Jr., Loring, G.L. and Brenner, C. FHA-RING Ubiquitin Ligases in Cell Division Cycle Control. Cell Mol Life Sci v. 18 in press (2008).
  • Wolyniak, M.F. and Cole, C.N. Harnessing genomics to explore the processes and evolution of mRNA export. RNA Biol 5:68-72 (2008).
  • Scarcelli, J.J., Viggiano, S., Hodge,C.A., Heath, C.V., Amberg, D.C. and Cole, C.N. Synthetic genetic array analysis in Saccharomyces cerevisiae provides evidence for an interaction between RAT8/DBP5 and genes encoding P body components. Genetics. In press (2008).
  • Hatzold, J. and Conradt, B. Control of apoptosis by asymmetric cell division. PLoS Biology 6(4):e84 (2008). Open access to full text on PLoS Biology .
  • Nilsson, L., Conradt, B., Raud, A.F., Chen, C.C., Hatzold, J., Bessereau, J.L., Grant, B.D. and Tuck, S. Caenorhabditis elegans num-1 negatively regulates endocytic recycling. Genetics 179:375-387 (2008).
  • Doonan, R., Hatzold, J., Raut, S., Conradt, B. and Alfonso, A. HIH-3 in a C.elegans Achaete/Scute protein required for differentiation of the hermaphrodite-specific motor neurons. Dev Dyn. In press.
  • Ow, M.C., Martinez, N.J., Olson, P.H., Silverman, S., Immaculada Barrasa, M., Conradt, B., Walhout, A.J.M. and Ambros, V. The FLYWCH transcription factors FLH-1, FLH-2 and FLH-3 repress embryonic expression of microRNA genes in C. elegans. Genes Dev. In press.
  • Dunlap, J.C. Salad days in the rhythms trade. Genetics 178(1):1-13 (2008). PMID: 18202353
  • Belden, W.J. and Dunlap, J.C. SIRT1 is a circadian deacetylase for core clock components. Cell 134:212-214 (2008).
  • Jude, C.D.*, Gaudet, J.*, Speck, N.A. and Ernst, P. Leukemia and Hematopoietic Stem Cells: Balancing Proliferation and Quiescence. Cell Cycle, 7(5):1-6 (2008).
  • McAllister, T., Tyler, A., Moore, J.H., Saykin, A. Single nucleotide polymorphisms in ANKK1 and the Dopamine D2 Receptor gene affect cognitive outcome shortly after traumatic brain injury: A replication and extension study. Brain Imaging, in press (2008).
  • Aguilar-Ruiz, J.S., Moore, J.H., Ritchie, M.D. Filling the gap between biology and computer science. BioData Mining 1:1 (2008).
  • Moore, J.H., Rhodes, C.H. Integration of molecular and cellular pathogenesis: A bioinformatics approach. In: Coleman, W.B., Tsongalis, G.J. (eds.), Molecular Pathology: The Molecular Basis of Human Disease, in press, Elservier (2008).
  • Greene, C.S., Moore, J.H. Ant colony optimzation for genome-wide genetic analysis. Lecture Notes in Computer Science, in press (2008).
  • Pattin, K.A., White, B.C., Barney, N., Gui, J., Nelson, H.H., Kelsey, K.R. Andrew, A.S., Karagas, M.R., Moore, J.H. A computationally efficient hypothesis testing method for epistasis analysis using multifactor dimensionality reduction. Genetic Epidemiology, in press (2008).
  • Moore, J.H., Greene, C.S., Andrews, P., White, B.C. Does complexity matter? Artificial evolution, computational evolution and the genetic analysis of common human diseases. In: Genetic Programming Theory and Practice VI, in press, Springer (2008).
  • Urbanowicz, R., White, B.C., Barney, N., Moore, J.H. Mask functions for the symbolic modeling of epistasis using genetic programming. Proceedings of the Genetic and Evolutionary Computing Conference. ACM Press, pp. 339-346 (2008).
  • Pattin, K.A., Moore, J.H. Exploiting the proteome to improve the genome-wide genetic analysis of epistasis in common human diseases. Human Genetics 124, 287-312 (2008).
  • Asselbergs, F.W., Pattin, K., Sneider, H., Hillege, H.L., van Gilst, W., Moore, J.H. Genetic architecture of tissue plasminogen activator and plasminogen activator inhibitor 1. Seminars in Thrombosis and Haemostasis, in press (2008).
  • Moore, J.H., Andrews, P.C., Barney, N., White, B.C. Development and evaluation of an open-ended computational evolution system for the genetic analysis of susceptibility to common human diseases. Lecture Notes in Computer Science 4973, 129-140 (2008). [Springer]
  • Wilke, R.A., Mareedu, R.K., Moore, J.H. The pathway less traveled: Moving from candidate genes to candidate pathways in the analysis of genome-wide data from large scale pharmacogenetic association studies. Current Pharmacogenomics and Personalized Medicine, in press (2008).
  • Moore, J.H. Analysis of gene-gene interactions. In: Dracopoli, N.C., Haines, J.L., Korf, B.R., Moir, D.T., Morton, C.C., Seidman, C.E., Seidman, J.G., Smith, D.R. (eds), Current Protocols in Human Genetics, Wiley-Liss, Inc., New York, 2nd Ed., in press (2008).
  • Moore, J.H., Karagas, M.R., Andrew, A.S. Novel analytical methods for association studies. In: Rebbeck, T., Ambrosone, C.B., Shields, P.G. (Eds.) Molecular Epidemiology: Applications in Cancer and Other Human Diseases. Informa Healthcare USA, Inc., pp. 169-187 (2008).
  • Moore, J.H. The critical need for computational intelligence in human genetics. Computing Reviews, Hot Topics, March 3 (2008).
  • Arehart, E., Stitham, J., Asselbergs, F.W., Douville, K., MacKenzie, T., Fetalvero, K.M., Gleim, S., Kasza, Z., Rao, Y., Martel, L., Segel, S., Robb, J., Kaplan, A., Simons, M., Powell, R.J., Moore, J.H., Rimm, E.B., Martin, K.A., Hwa, J. Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation, potential implications for COX-2 inhibition. Circulation Research 102:986-993 (2008).
  • Andrew, A.S., Jewell, D., Mason, R., Whitfield, M., Moore, J.H., Karagas, M.R. Drinking water arsenic exposure modulates gene expression in human lymphocytes. Environmental Health Perspectives 116:524-531 (2008).
  • Berretta, L., Cappiello, J.H., Moore, J.H., Scorza, R. Interleukin-1 gene complex single nucleotide polymorphisms in systemic sclerosis: A further step ahead. Human Immunology 69:187-192 (2008).
  • Berretta, L., Cappiello, J.H., Moore, J.H., Greene, C.S., Barili, M., Scorza, R. Epistatic interactions of cytokine single nucleotide polymorphisms predict susceptibility to disease subsets in systemic sclerosis patients. Arthritis and Rheumatism 59:974-983 (2008).
  • Reif, D.M., McKinney, B.A., Motsinger, A., Chanock, S.J., Edwards, K.M., Rock, M.T., Moore, J.H., Crowe, J.E. Jr. Genetic basis for adverse events following smallpox vaccination. Journal of Infectious Diseases, in press (2008).
  • Moore, J.H. Bases, bits and disease: A mathematical theory for human genetics. European Journal of Human Genetics 16, 143-144 (2008).
  • Moore, J.H., Barney, N., White, B.C. Solving complex problems in human genetics using genetic programming: The importance of theorist-practitioner-computer interaction. In: Riolo, R., Soule, T., Worzel, B. (eds.) Genetic Programming Theory and Practice V, Springer, pp. 69-85 (2008).
  • Moore, J.H. Bioinformatics. In: Wild, C., Vineis, P., Garte, S. (eds.) Molecular Epidemiology of Chronic Diseases, Wiley, pp 233-242 (2008).
  • Moore, J.H., Karagas, M., Andrew, A.S. Analysis of complex datasets. In: Wild, C., Vineis, P., Garte, S. (eds.) Molecular Epidemiology of Chronic Diseases, Wiley, pp. 207-222 (2008).
  • Marchiori, E., Moore, J.H. (eds.) Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics. Lecture Notes in Computer Science 4974, Springer (2008).
  • Sloan, C., Sayarath, V., Moore, J.H. Systems genetics of alcoholism. Alcohol Research and Health 31, 14-25 (2008).
  • Duell, E.J., Bracci, P.M., Moore, J.H., Burk, R.D., Kelsey, K.T., Holly, E.A. Detecting complex, pathway-based gene-gene and gene-environment interactions in pancreatic cancer. Carcinogenesis 17:1470-1479 (2008).
  • Thornton-Wells, T.A., Moore, J.H., Haines, J.L. Confronting complexity in late-onset Alzheimer disease: Application of two-stage analysis approach addressing heterogeneity and epistasis. Genetic Epidemiology 32, 187-203 (2008).
  • Andrew, A.S., Karagas, M.R., Nelson, H.H., Guarrera, S., Polidoro, S., Gamberini, S., Sacerdote, C., Moore, J.H., Kelsey, K.T., Vineis, P., Matullo, G. Assessment of multiple DNA repair gene polymorphisms and bladder cancer susceptibility in a joint Italian and U.S. population: a comparison of alternative analytic approaches. Human Heredity 65:105-118 (2008).
  • Starostina, E., Xu, A., Lin, H., Pikielny, CW. A Drosophila protein family implicated in pheromone perception is related to Tay-Sachs GM2-activator protein. Journal of Biological Chemistry (in Press, published online October 24, 2008).
  • Clayton, J.E., van den Heuvel, S.J. and Saito, R.M. Transcriptional control of cell-cycle quiescence during C. elegans development. Dev Biol 313:603-613 (2008). PMID: 18082681
  • Milano, A., Pendergrass, S.A., Sargent, J.L., George, L.K., McCalmont, T.H., Connolly, M.K. and Whitfield, M.L. Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin. PLos One 3(7):e2696 (2008). Open access to full text on PLoS One .

 

Last Updated: 10/28/08