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Call for Proposals for Pilot Projects in Biodosimetry

The Dartmouth Physically-Based Biodosimetry Center for Medical Countermeasures Against Radiation
(Dart-Dose CMCR) is pleased to announce:
An On-going Call for Proposals for
Research and Development of Methods to Assess Radiation Dose

Basic Facts:

  • Funds Available: Maximum of $50,000 for one year. All applicant institutions are requested to forego indirects in the pilot budget.
  • Number of Awards: We expect to fund about 8 one year projects in each of 5 grant years, from 2010 to 2015.
  • Award Project Period:One year in length; however, some pilot projects may be invited to compete for a second year of funding; 2 years total is the maximum.
  • Submission Process:
    • Step 1 - Submit White Paper: A one-page White Paper should include study aims, overall rationale, and approach. Also supply a brief budget and biosketches of the principal investigator and co-investigators using the NIH Biographical Sketch Format Page which can be found at this link.
    • Step 2 - Submit Formal Proposal: Following review of your White Paper you may be invited to submit a Formal Proposal. If invited, this step involves submitting a short Research Plan (4 pages maximum), and the usual NIH 398 forms. The Research Plan should also specify products and other deliverables to be submitted to the EPR Center and a timetable for their delivery. Deliverables and references do not count toward the 4 page maximum. Some information required by NIH (Other support and IRB and IACUC approvals) may be submitted "Just-in-Time"(i.e., after being informed that we intend to fund your proposal).
  • Timetable: White Papers may be submitted at any time. Notification of the White Paper review outcome is usually within 2 weeks of submission. An invited Formal Proposal is to be submitted within 6 weeks of invitation. Preliminary approval of the Formal Proposal may be indicated within 3 weeks of the date of submission. Final approval of the Formal Proposal, which requires NIAID's review, is usually within 3 months of the date of the Formal Proposal's submission to Dart-Dose CMCR.
  • Project Start Date: Within 1 month of final approval by NIAID.
  • Topics: The Dart-Dose CMCR Pilot Projects are principally intended to foster the development of innovative advances related to the overall goals of the Dart-Dose CMCR whose goals are to advance the scientific knowledge and effectiveness and efficiency of techniques and instrumentation for physical biodosimetry to be used for triaging victims of a mass casualty event involving radiation. Therefore, it is anticipated that pilot project topics will usually be related to biodosimetry, especially in the context of a large radiation disaster. Other topics related to medical countermeasures against radiation will be considered.

Project Types: [back to top]

Projects can be one of two types: "Full" or "Focused". Investigators, especially for focused projects, will usually work with a co-investigator who is already involved in the Dart-Dose CMCR. (Dart-Dose CMCR personnel should not be included in the pilot budget or named as a specific pilot project investigator.) These two project types, and examples of research interests, are briefly described below. Examples of funded projects can be viewed here.

Full pilot projects [back to top]: These projects should have the potential to develop into full, independent research projects at the conclusion of their pilot project period. A successful full pilot project proposal will have a clear relevance to radiation biodosimetry, and especially to the goals of the Dart-Dose CMCR and, as appropriate, to its projects and cores. In addition, the proposal should include a plan for transitioning from a developmental pilot project into a full-scale project as well as potential funding sources. Full pilot project proposals may request funding for up to $50,000 per year and may be competitively renewed for an additional year. Applicants for a second year of funding will be required to submit a satisfactory project year 01 progress report. The decision to fund will be made with strong input from the Pilot Project Review Committee and the External Advisory Committee for the Dart-Dose CMCR.

  • Full Pilot Project Example 1: Projects using other forms of physical biodosimetry such as optically stimulated luminescence (OSL); OSL could provide an alternative way to assess dose using teeth or fingernails and may complement some aspects of ESR biodosimetry in terms of field-availability or use in patients less suited for EPR biodosimetry.
  • Full Pilot Project Example 2: Projects using biologically based biodosimetry that also have a strong physical basis (e.g., the formation of micronuclei, which is a prompt physical process-- breaking off a piece of a chromosome, also has some biologically based processing steps); these biodosimeters are valuable in their own right and might also shed additional insights into the roles and values of physical vs. biological biodosimeters.
  • Full Pilot Project Example 3: Projects using EPR techniques that Dartmouth is not currently using such as pulsed EPR or EPR imaging. Instrumentation using these techniques could complement existing EPR biodosimetry approaches and/or enhance the capacity to adapt existing instruments in an emergency to be used for biodosimetry. As examples of complementarity, EPR imaging could be used to identify the spatial locations of radicals in both tooth and fingernail samples.
  • Full Pilot Project Example 4: Projects that fit broadly into the mission of the NIAID CMCRs, such as development of drugs to mitigate or modify the response to radiation.
  • Full Pilot Project Example 5: Projects that increase the effectiveness of biodosimetry in the context of being a point-of-service, field-deployable device.

Focused pilot projects [back to top]: These proposals may identify important technology or research questions associated with one of the Dart-Dose CMCR projects or cores but not otherwise included in their planned work. Projects of this nature are not expected to develop into full, independent research projects; however, their objectives should benefit overall goals of the Dart-Dose CMCR. These proposals may be funded for up to $50,000 for one year and are not generally expected to be competitive for a second year of funding.

  • Focused Pilot Project Example 1: Projects that provide important developments that would directly fit into existing projects such as methods for rapid and accurate insertion of resonators that are not part of the current research plan for the tooth biodosimetry project and methods to automatically detect the presence of tooth implants/veneers. Another example would be engineering models to optimize design of resonator loops.
  • Focused Pilot Project Example 2: Projects that model whole-body and critical organ doses based on biodosimetry with spatial resolution such as can be obtained with EPR of nails.

Contact Information for Inquiries: [back to top]

  • Ann Barry Flood, Ph.D. [Director of Pilot Project Core at Dart-Dose CMCR and Associate Director of Dart-Dose CMCR] via email (Ann.B.Flood@Dartmouth.edu) or at 603.650.1784 (main # for Dart-Dose CMCR) or 603.650.1677
  • Harold M. Swartz, M.D., Ph.D. [Director and PI of Dart-Dose CMCR] via email (Harold.M.Swartz@Dartmouth.edu) or at 603.650.1955
  • Catherine C. Lindsay, S.M. [Assistant Director of Pilot Project Core at Dart-Dose CMCR] via email (Catherine.C.Lindsay@Dartmouth.edu) or at 603.650.1619
  • Address: Dartmouth Physically-Based Biodosimetry Center for Medical Countermeasures against Radiation, 48 Lafayette St., HB7785, Lebanon, NH 03766
  • Send White Papers and Formal Proposals to: Drs. Ann Barry Flood and Harold M. Swartz

Frequently Asked Questions: [back to top]

Additional information on the Dart-Dose CMCR Pilot Projects can be found in the FAQs. Please read through them as they contain important information on the application process.

Funded Pilot Projects: [back to top]

A list of the funded pilot projects is available here.

Pilot Projects Publication and Presentation: [back to top]

A list of the Pilot Projects Publication and Presentations is available here.

Email Notifications: [back to top]

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