Table 21-4. Causes of Polyneuropathy

  1. Metabolic
    1. Diabetic, uremic, hypothyroid, liver failure
    2. Porphyria
  2. Nutritional
    1. Deficiency of vitamin B1, B6, B12, vitamin E; excess of pyridoxine
  3. Toxic
    1. Alcohol
    2. Drugs: many drugs (see this list)
    3. Heavy metals
    4. Organic solvents (see this list)
  4. Infectious
    1. HIV, Lyme, leprosy, diptheria
  5. Inflammatory
    1. Guillain-Barre
    2. Chronic inflammatory demyelinating polyneuropaty (CIDP)
    3. Vasculitis (such as lupus, rheumatoid arthritis, polyarteritis nodosa, Sjögren's syndrome)
  6. Dysproteinemia
    1. Amylodosis (hereditary and sporadic)
    2. Monoclonal gammopathy of uncertain significance (MUGUS)
  7. Paraneoplastic
  8. Hereditary (see this list)
    1. Charcot-Marie-Tooth disease types 1,2,3 and X
    2. Familial amyloidosis
    3. Hereditary predisposition to pressure palsies
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