Clinical Trial Studies

 

Title

Phase PI Category
Treatment of multiple sclerosis with anti-CD154: a phase II double-blind partial cross-over clinical trial (IDEC). Mechanistic Kasper monitoring
Protocol for use of brain tumor tissue for research. Monitor Fadul monitoring

A trial of a CD40 activated dendritic cell vaccine in patients with resected colorectal cancer.

Phase II Barth vaccine/                    monitoring

The effect of CNTO 1275 on the immune responses of peripheral blood cells from subjects with relapsing forms of multiple sclerosis (Centocor).

 

Mechanistic Kasper monitoring

Dose-escalation study of EMD 273066 administered with low-dose cyclophosphamide to subjects with epithelial cell adhesion      molecule (EpCAM) positive advanced cancers.

 

Phase I Ernstoff cellular

Dose dependent induction of T regulatory cells by glatiramer   acetate: a parallel mechanistic study to GA9016 (TEVA Pharmaceuticals)

 

Mechanistic Kasper monitoring
Longitudinal study of mild cognitive Iimpairment and early  Alzheimer’s disease. Monitor Saykin cytokine
Autologous PBSC and immunotherapy for myeloma Phase III Meehan cellular/                    cytokine
Immune mobilization of autologous PBSC with IL-2 and GM-CSF Phase III Meehan cytokine
Immunologic evaluation of peripheral blood Monitor Ernstoff monitoring
Autologous tumor/DC vaccine + IL-2 & IFNα in renal cell cancer Phase II Ernstoff vaccine/                    cytokine
Pre-clinical studies for development of a DC in GBM Pilot Fadul vaccine
IL-2 in lymphodepleted primed melanoma patients Phase II Ernstoff cytokine
Adjuvant intra-nodal autologous DC in GBM Phase II Fadul vaccine
Cryoablation as immunomodulator in breast cancer Pilot Barth vaccine/                    monitoring

VEGF blockade autologous DC, IL-2, and IFNa-2b in renal cell cancer   

Phase II Ernstoff vaccine/              cytokine
Cellular immunoRx, after autologous PBST for myeloma Phase II Meehan cellular
Modulation of immune system by VEGF in GBM Pilot Fadul antibody
Melanoma and renal tumor tissue bank extension Monitor Ernstoff monitoring

Immune endpoints in blood & BM myeloma and healthy subjects

 

Monitor Meehan monitoring
Immunological effects of GM-CSF/vaccine in renal cell cancer and melanoma Pilot Ernstoff vaccine/            cytokine
Leukapheresis for immunological endpoints Monitor Ernstoff monitoring
GM-CSF in patients with prostate cancer Pilot Ernstoff cytokine
Bevacizumab + IL-2 in renal cell cancer Phase II Ernstoff cytokine/              antibody
Melacine plus IFNa-2b vs. IFNa-2b in melanoma Phase III Ernstoff vaccine/                 cytokine

Induction of T regulatory cells in relapsing-remitting multiple sclerosis following treatment with anti-CD52 (Campath 1-H; Genzyme)

 

Mechanistic Kasper cellular/                    cytokine

Induction of T regulatory cells and the effect on B cells by IFNb-1b (Bayer)


Mechanistic Kasper monitoring

The relationship between thymic activity, regulatory T-cells and    functional immune status in organ transplantation with alemtuzumab (Campath-1H) pretreatment and tacrolimus monotherapy.

 

Pilot Zuckerman cellular

The effect of psychosocial and behaviorally-based interventions on biological outcomes of patients with an advanced cancer diagnosis.

 

Pilot Bakitas cellular/                   cytokine

Evaluation of the effect of age and prior immunity on the response to live or inactivated seasonal influenza vaccines in children.

 

Pilot Wright cellular/ cytokine
An open-label, dose-escalation, phase I study of the safety, tolerability and immunogenicity of the prime-boost regimen of the investigational 2012/13 seasonal influenza DNA vaccine followed by the 2012/2013 seasonal influenza trivalent inactivated vaccine (TIV) compared to TIV prime-TIV boost in children and adolescents ages 6-17 Years.
Phase I
Wright cellular/ cytokine