TRRAP is a unique member of the

 PI-3 kinase/ATM family

1

3830

434 kDa (3830 amino acid) nuclear protein

N-terminal 90% is unique

C-terminal 300 amino acids homologous to the PI-3 kinase family

Other interesting members of the PI-3 kinase family

Mutated in ataxia telegiectasia (ATM) - predisposition to cancer

MEC1/TEL1/RAD3 - cell cycle checkpoint defects in yeasts

DNA-PK - radiation sensitivity and DNA repair defect

TOR1/TOR2 - target of rapamycin (G1 arrest)

PI-3 kinase - signal transduction

TRRAP lacks the canonical kinase catalytic site

and has no kinase activity

-Cole web site